Name: quantification of atherosclerotic plaque activity and vascular inflammation using [18-f] fluorodeoxyglucose positron emission tomography/computed tomography (fdg-pet/ct)
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Description: Watch this Scientific Journal Video about Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography F

NNM은 국립 건선 재단, NHLBI 5K23HL97151-3와 HL111293에서 교부금에 의해 지원됩니다. JMG는 NHLBI R01과 R01 HL089744 HL111293에 의해 지원됩니다.

1. 환자 준비 및 취득 이미지 <ol><li> 향상된 이미지 품질을위한 시간의 비행 능력과 선호 하나, PET / 중부 표준시 스캐너에 적어도 한 시간 이미징 타임 슬롯을 고정합니다. 우리 기관에서, 우리는 필립스 의료 시스템에서 최신 PET / 중부 표준시 시스템이며 16 슬라이스 증명 중부 표준시 시스템 리소 탐지기를 기반으로 PET 스캐너를 결합 쌍둥이 자리 TF 스캐너를 사용합니다. </li><li> FDG-PET/CT 검사 ?...

<ol>
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K. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Fibrous+and+lipid-rich+atherosclerotic+plaques+are+part+of+interchangeable+morphologies+related+to+inflammation:+a+concept.">Fibrous and lipid-rich atherosclerotic plaques are part of interchangeable morphologies related to inflammation: a concept.</a> Coron. Artery Dis. 5, 463-469 (1994).</li><li>Alavi, A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Positron+emission+tomography+imaging+of+regional+cerebral+glucose+metabolism.">Positron emission tomography imaging of regional cerebral glucose metabolism.</a> Semin. Nucl. Med. 16, 2-34 (1986).</li><li>Hustinx, R. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Dual+time+point+fluorine-18+fluorodeoxyglucose+positron+emission+tomography:+a+potential+method+to+differentiate+malignancy+from+inflammation+and+normal+tissue+in+the+head+and+neck.">Dual time point fluorine-18 fluorodeoxyglucose positron emission tomography: a potential method to differentiate malignancy from inflammation and normal tissue in the head and neck.</a> Eur. J. Nucl. Med. 26, 1345-1348 (1999).</li><li>Ogawa, M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=(18)F-FDG+accumulation+in+atherosclerotic+plaques:+immunohistochemical+and+PET+imaging+study.">(18)F-FDG accumulation in atherosclerotic plaques: immunohistochemical and PET imaging study.</a> J. Nucl. Med. 45, 1245-1250 ( ).</li><li>Yun, M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=F-18+FDG+uptake+in+the+large+arteries:+a+new+observation.">F-18 FDG uptake in the large arteries: a new observation.</a> Clin. Nucl. Med. 26, 314-319 (2001).</li><li>Mehta, N. N. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Systemic+and+Vascular+Inflammation+in+Patients+With+Moderate+to+Severe+Psoriasis+as+Measured+by+[18F]-Fluorodeoxyglucose+Positron+Emission+Tomography-Computed+Tomography+(FDG-PET/CT):+A+Pilot+Study.">Systemic and Vascular Inflammation in Patients With Moderate to Severe Psoriasis as Measured by [18F]-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography (FDG-PET/CT): A Pilot Study.</a> Arch. Dermatol. , .</li><li>Davies, J. R. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=FDG-PET+can+distinguish+inflamed+from+non-inflamed+plaque+in+an+animal+model+of+atherosclerosis.">FDG-PET can distinguish inflamed from non-inflamed plaque in an animal model of atherosclerosis.</a> Int. J. Cardiovasc. Imaging. 26, 41-48 (2011).</li><li>Bural, G. G. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=FDG-PET+is+an+effective+imaging+modality+to+detect+and+quantify+age-related+atherosclerosis+in+large+arteries.">FDG-PET is an effective imaging modality to detect and quantify age-related atherosclerosis in large arteries.</a> Eur. J. Nucl. Med. Mol. Imaging. 35, 562-569 (2008).</li><li>Arauz, A., Hoyos, L., Zenteno, M., Mendoza, R., Alexanderson, E. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Carotid+plaque+inflammation+detected+by+18F-fluorodeoxyglucose-positron+emission+tomography.+Pilot+study.">Carotid plaque inflammation detected by 18F-fluorodeoxyglucose-positron emission tomography. Pilot study.</a> Clin. Neurol. Neurosurg. 109, 409-412 (2007).</li><li>Rominger, A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=18F-FDG+PET/CT+identifies+patients+at+risk+for+future+vascular+events+in+an+otherwise+asymptomatic+cohort+with+neoplastic+disease.">18F-FDG PET/CT identifies patients at risk for future vascular events in an otherwise asymptomatic cohort with neoplastic disease.</a> J. Nucl. Med. 50, 1611-1620 (2009).</li><li>Wasselius, J. A., Larsson, S. A., Jacobsson, H. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=FDG-accumulating+atherosclerotic+plaques+identified+with+18F-FDG-PET/CT+in+141+patients.">FDG-accumulating atherosclerotic plaques identified with 18F-FDG-PET/CT in 141 patients.</a> Mol. Imaging Biol. 11, 455-459 (2009).</li><li>Tahara, N. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Simvastatin+attenuates+plaque+inflammation:+evaluation+by+fluorodeoxyglucose+positron+emission+tomography.">Simvastatin attenuates plaque inflammation: evaluation by fluorodeoxyglucose positron emission tomography.</a> J. Am. Coll. Cardiol. 48, 1825-1831 (2006).</li><li>Lee, S. 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여기에 제시된 방법론은 수행 간단하고, 임상적으로 크게 동맥 침대에서 atherosclerotic 플라크 활동 및 혈관 염증에 관한 유용한 정보를 얻을 수 있습니다. 중점을 보증 이러한 분석 방법의 몇 가지 중요한 특징이 있습니다 : 1) 우리는 16 검출기 행이있는 고품질의 PET / 중부 표준시 스캐너를 사용하여 비행 능력의 시간과, 2) 우리에게 임상 정보를 멀게이 경험 관측을 활용 양적 데이터의 일관성을 보...

quantification of atherosclerotic plaque activity and vascular inflammation using [18-f] fluorodeoxyglucose positron emission tomography/computed tomography (fdg-pet/ct)

이러한 관상 동맥 칼슘 (CAC) 1과 경동맥 내막 중간 두께 (C-IMT) 2과 같은 죽상 경화증의 전통적인 비침습 이미징 modalities는 질병의 부담에 대한 정보를 제공합니다. 다만, CAC 3-5 및 C-IMT 2,6 여러 검증 연구에도 불구하고, 따라서 위험을 이러한 modalities가 정확 상패 특성에게 7,8을 평가하지 않으며, 플라크의 조성과 염증 상태의 안정성을 결정하고 임상 이벤트 9-13니다. [18 F]-2-플루오로 -2 - 데옥시-D-글루코오스 양전자 - 방출 tomography (PET) / 계산된 tomography (중부 표준시)를 사용 (FDG) 이미징은 광범위 oncologic 대사 14,15 공부했습니다. 인간의 동물 모델과 immunohistochemistry를 사용하여 연구 FDG-PET/CT는 대식 세포 활동 16, 혈관 벽의 세포 염증의 중요한 원인을 검출 묘할 정도로 민감는 것을 보여줍니다. 모최근 다시, 우리는 17,18 그리고 다른 FDG-PET/CT 대규모 및 중간 크기의 동맥 9,16,19,20의 atherosclerotic plaques의 활동 염증성 활동을 고도로 정밀하게, 소설 측정을 가능하게하는 것으로 나타났습니다. FDG-PET/CT 연구는 다른 이미징 modalities 이상의 많은 장점이 있습니다, 멀티 모달 atherosclerotic 플라크의 부량 수있게 2) 상패 볼륨의 양을 정함과 신진 대사 활동, 3) 동적, 실시간, 생체내 이미징 1) 높은 콘트라스트 해상도를; 4) 최소한의 운영자 의존성. 마지막으로, FDG-PET/CT 감지 혈관 염증은 전통적인 위험 요인 21,22의 독립적인 심혈관 (CV) 이벤트를 예측을 보여줘왔다 또한 고도의 죽상 경화증 23 전반적인 부담과 연결됩니다. FDG-PET/CT에 의한 플라크의 활동은 단기 (12 주) 스타틴 치료 24뿐만 아니라, 장기 치료 라이프 스타일 변화 (16 개월) 25 알려진 유익 이력서의 개입에 의해 변조된입니다. </P&gt; atherosclerotic 플라크의 FDG의 이해의 부량에 대한 현재 방법론은 나누어 계산 배경 비율 (TBR)에게 대상을 계산하기 위해서는 관심있는 동맥의 표준 이해 값 (SUV)와 정맥 피 웅덩이의 측정을 포함 정맥의 피가 수영장 SUV에 의한 동맥 SUV. 이 방법은 시간이 지남에 따라 안정적이고 재현성 표현형을 나타내기 위해 표시 혈관 염증의 검출을위한 높은 감도를 가지고 있으며, 또한 높은 간 및 내부 리더의 신뢰성 26 가지고있다. 여기 신진 대사 체적 제품 (MVP)로 불리는 SUV, TBR, 그리고 글로벌 매개 변수를 사용 atherosclerotic 플라크 활동 및 혈관 염증의 환자 준비, 이미지 수집 및 부량 위해 우리의 방법론을 제시한다. 우리는 몇 가지 사전 출판물에 나타난 바와 같이 이러한 접근 방식은 일관성있는 패션에 대한 관심의 다양한 연구 샘플에서 혈관 염증을 평가하기 위해 적용될 수 있습니다. 9,20,27,28는 &lt;/ 저녁을 먹다&gt;

Watch this Scientific Journal Video about Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography F

Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography FDG-PET/CT

비 invasively 죽상 경화증을 식별하고, 여기서 우리가 FDG-PET/CT가 atherosclerotic 플라크 활동 및 혈관 염증을 감지하고 계량하는 데 사용할 수있는 방법을 설명하는 훌륭한 필요가있다.

Atherosclerotic 플라크 현황 및 혈관 염증의 부량 사용하여 [을 18-F] Fluorodeoxyglucose 양전자 방출 Tomography / 계산된 Tomography (FDG-PET/CT)

Conventional non-invasive imaging modalities of atherosclerosis such as coronary artery calcium (CAC)1 and carotid intimal medial thickness (C-IMT)2 ...

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Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG-PET/CT)

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Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG

Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG

과 양전자 방출 단층 촬영을 이용하여 비 침습적 영상 및 뇌허혈의 분석 생활 쥐<sup&gt; (18)</sup&gt; F-FDG

Stroke is the third leading cause of death among Americans 65 years of age or older1. The quality of life for patients who suffer from a stroke fails to ...

Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images

인간의 갈색 지방 조직의 종점은 자동으로 양전자 방출 단층 촬영 / 전산화 단층 촬영 분단과 자기 공명 이미지 등록

Reliably differentiating brown adipose tissue (BAT) from other tissues using a non-invasive imaging method is an important step toward studying BAT in ...

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

대동맥 석회화와 염증의 혈관 평활근 세포 및 이미지의 석회화

Cardiovascular disease is the leading cause of morbidity and mortality in the world.  Atherosclerotic plaques, consisting of lipid-laden macrophages and ...

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

건조 분말과 제약의 분무 에어로졸 흡입은 코 전용 노출 시스템을 사용하여 마우스 배달

Obstructive respiratory diseases like asthma and chronic obstructive pulmonary disease (COPD) are currently treated by inhaled anti-inflammatory and ...

Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation

검색 및 대 식 세포 관련 Murine 창 자 염증의 정량화에 대 한 단층 형광 중재

Murine models of disease are indispensable to scientific research. However, many diagnostic tools such as endoscopy or tomographic imaging are not ...

Whole Body and Regional Quantification of Active Human Brown Adipose Tissue Using 18F-FDG PET/CT

Whole Body and Regional Quantification of Active Human Brown Adipose Tissue Using 18F-FDG PET/CT

In endothermic animals, brown adipose tissue (BAT) is activated to produce heat for defending body temperature in response to cold. BAT&#39;s ability to ...

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

부드러운 근육 세포 계보 추적 마우스의 고급 동맥 경 화성 병 변에서 세포 성분의 정량 분석

Atherosclerosis remains the leading cause of death worldwide and, despite countless preclinical studies describing promising therapeutic targets, novel ...