Name: monitoring the wall mechanics during stent deployment in a vessel
Uploaded: 2012-05-08T12:00:00
Description: Watch this Scientific Journal Video about Monitoring the Wall Mechanics During Stent Deployment in a Vessel at JoVE.com

Denne undersøgelse blev støttet delvist af NASA Nebraska Space Grant og National Science Foundation under tilskud nr. 0926880.

1. Forberedelsen af ​​latexen Vessel <ol><li> Fastsætte begge ender af latex fartøjet modhager slangeforbindelser, som er fastgjort på en stabil arbejdsbord. </li><li> Måle arealet af interesse på latex fartøjet for at bestemme synsfelt. Det område af interesse for en stent test bør være centreret mellem de barbed slangekoblinger og omfatter cirka en tomme på hver side af stenten for at observere de stammer uden for stentet området. </li><li> Optage afstand fra den udvendige kant af en modhage slangemuf...

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	<li>Fischman, D. L., Leon, M. B., Baim, D. S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=A+randomized+comparison+of+coronary-stent+placement+and+balloon+angioplasty+in+the+treatment+of+coronary+artery+disease.+Stent+Restenosis+Study+Investigators.">A randomized comparison of coronary-stent placement and balloon angioplasty in the treatment of coronary artery disease. Stent Restenosis Study Investigators.</a> N. Engl. J. Med. 331, 496-501 (1994).</li><li>Abul Hasan Muhammad Bashar, T. K. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Mechanical+Properties+of+Various+Z-Stent+Designs:+An+Endovascular+Stent-Grafting+Perspective.">Mechanical Properties of Various Z-Stent Designs: An Endovascular Stent-Grafting Perspective.</a> Artificial Organs. 27, 714-721 (2003).</li><li>Nuutinen, J. u. h. a. -. P. e. k. k. a. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Mechanical+properties+and+in+vitro+degradation+of+bioabsorbable+self-expanding+braided+stents.">Mechanical properties and in vitro degradation of bioabsorbable self-expanding braided stents.</a> Journal of Biomaterials Science -- Polymer Edition. , 255-266 (2003).</li><li>C. Schulz, R. A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Coronary+stent+symmetry+and+vascular+injury+determine+experimental+restenosis.">Coronary stent symmetry and vascular injury determine experimental restenosis.</a> Heart. 83, 462-467 (2000).</li><li>Jiménez, J. M., Davies, P. F. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Hemodynamically+Driven+Stent+Strut+Design.">Hemodynamically Driven Stent Strut Design.</a> Annals of Biomedical Engineering. 1483, (2009).</li><li>Johnston, C. R. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+Mechanical+Properties+of+Endovascular+Stents:+An+In+Vitro+Assessment.">The Mechanical Properties of Endovascular Stents: An In Vitro Assessment.</a> Cardiovascular Engineering: An International Journal. 10, 128-135 (2010).</li><li>Mejia, J. u. a. n. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Evaluation+of+the+effect+of+stent+strut+profile+on+shear+stress+distribution+using+statistical+moments.">Evaluation of the effect of stent strut profile on shear stress distribution using statistical moments.</a> Biomedical Engineering Online. , 1-10 (2009).</li><li>. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=.">.</a> ARAMIS User Manual. , (2009).</li><li>Chesler, N. C., Thompson-Figueroa, J., Millburne, K. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Measurements+of+Mouse+Pulmonary+Biomechanics.">Measurements of Mouse Pulmonary Biomechanics.</a> Journal of Biomechanical Engineering. 126, 309-314 (2004).</li><li>de Korte, C. L., Sierevogel, M. J., Mastik, F., Strijder, C., Schaar, J. A., Velema, E., Pasterkamp, G., Serruys, P. W., van der Steen, A. F. W. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Identification+of+Atherosclerotic+Plaque+Components+With+Intravascular+Ultrasound+Elastography+In+Vivo+A+Yucatan+Pig+Study.">Identification of Atherosclerotic Plaque Components With Intravascular Ultrasound Elastography In Vivo A Yucatan Pig Study.</a> Circulation. 105, 1627-1630 (2002).</li></ol>

Stereo optisk overflade stamme målesystem anvendes til at måle de lokale belastninger over deformerende overfladen både ind-og ud-af-planet bevægelser uden at kontakte prøven. Dette system bruger to høj-hastigheds optiske kameraer til at tage billeder af et tilfældigt kontrasterende mønster sætte på overfladen at konstruere nøjagtige målinger af bevægelser i hvert punkt, med en høj nøjagtighed til at løse overflade stammer. Det skal bemærkes, at den krævede kontrasterende m...

<table border="1"><tbody><tr><td> Udstyr, der anvendes </td><td> Firma </td><td> Katalog nummer </td><td> Kommentarer </td></tr><tr><td> ARAMIS Camera System </td><td> GOM: Optiske måleteknikker </td><td></td><td></td></tr><tr><td> Palmaz Genesis transhepatisk biliær Stent </td><td> Cordis Corporation </td><td> PG5910B </td><td> Ballon-stent </td></tr><tr><td> Z-MED ballondilatationskateter </td><td> B. Braun Medical Inc. </td><td> PDZ336 </td><td> Ballondilatationskateter </td></tr></tbody></table>

monitoring the wall mechanics during stent deployment in a vessel

Kliniske studier har rapporteret forskellige restenosis satser for forskellige udformninger af stents 1. Det antages, at stent-inducerede stamme koncentrationer på arterievæggen føre til vævsbeskadigelse, der initierer restenose 2-7. Denne hypotese skal yderligere undersøgelser, herunder bedre kvantificering af ikke-ensartet stamme fordeling på arterien efter stent implantering. En ikke-kontaktoverflade stamme målemetode til stentet arterien er præsenteret i dette arbejde. ARAMIS stereo optisk overflade belastning målesystem bruger to optiske højhastigheds kameraer til at fange bevægelsen af hvert referencepunkt, og løse tredimensionelle stammer over den deformerer overfladen 8,9. Som mesh stenten i en latex beholder med et tilfældigt kontrasterende mønster sprøjtet eller trækkes på sin ydre overflade er overfladen stamme optegnes ved hvert øjeblik deformationen. De beregnede belastning fordelinger kan derefter anvendes til at forstå local læsion svar, validere beregningsmodeller, og formulere hypoteser for yderligere in vivo-undersøgelse.

Watch this Scientific Journal Video about Monitoring the Wall Mechanics During Stent Deployment in a Vessel at JoVE.com

Monitoring the Wall Mechanics During Stent Deployment in a Vessel

Stent-inducerede arterielle belastning fordelinger er karakteriseret ved anvendelse af en optisk overflade stamme målesystem. Denne visualisering teknik bruges til at få indblik i konsekvenserne af stent implantation på værten fartøjet.

Overvågning af Wall Mekanik Under Stent Deployment i en beholder

Clinical trials have reported different restenosis rates for various stent designs1. It is speculated that stent-induced strain concentrations on the ...

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