Name: controlling the size, shape and stability of supramolecular polymers in water
Uploaded: 2012-08-02T12:00:00
Duration: 16 min 24 s
Description: Watch this Scientific Journal Video about Controlling the Size, Shape and Stability of Supramolecular Polymers in Water at JoVE.com

लेखकों को कृतज्ञता DOSY एनएमआर साथ सहायता के Marko Nieuwenhuizen के लिए स्वीकार करते हैं.

<ol>
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Soc. 130, 606-611 (2008).</li><li>Jonkheijm, P., van der Schoot, P., Schenning, A. P. H. J., Meijer, E. W. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Probing+the+solvent-assisted+nucleation+pathway+in+chemical+self-assembly.">Probing the solvent-assisted nucleation pathway in chemical self-assembly.</a> Science. 313, 80-83 (2006).</li><li>Bosman, A. W., Janssen, H. M., Meijer, E. W. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=About+dendrimers:+structure,+physical+properties,+and+applications.">About dendrimers: structure, physical properties, and applications.</a> Chem. Rev. 99, 1665-1688 (1999).</li><li>Veld, M. A. J., Haveman, D., Palmans, A. R. A., Meijer, E. W. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Sterically+demanding+benzene-1,3,5-tricarboxamides:+tuning+the+mechanisms+of+supramolecular+polymerization+and+chiral+amplification.">Sterically demanding benzene-1,3,5-tricarboxamides: tuning the mechanisms of supramolecular polymerization and chiral amplification.</a> Soft Matter. 7, 524-531 (2011).</li><li>Stals, P. J. M., Smulders, M. M. J., Mart&#237;n-Rap&#237;n, R., Palmans, A. R. A., Meijer, E. W. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Asymmetrically+substituted+benzene-1,3,5-tricarboxamides:+self-assembly+and+odd-even+effects+in+the+solid+state+and+in+dilute+solution.">Asymmetrically substituted benzene-1,3,5-tricarboxamides: self-assembly and odd-even effects in the solid state and in dilute solution.</a> Chem. Eur. J. 15, 2071-2080 (2009).</li><li>De Greef, T. F. A., Smulders, M. M. J., Wolffs, M., Schenning, A. P. H. J., Sijbesma, R. P., Meijer, E. W. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Supramolecular+polymerization.">Supramolecular polymerization.</a> Chem. Rev. 109, 5687-5754 (2009).</li><li>Smulders, M. M. J., Nieuwenhuizen, M. M. L., de Greef, T. F. A., Schoot, P. v. a. n. d. e. r., Schenning, A. P. H. J., Meijer, E. W. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=How+to+distinguish+isodesmic+from+cooperative+supramolecular+polymerization?+Chem.">How to distinguish isodesmic from cooperative supramolecular polymerization? Chem.</a> Eur. J. 16, 362-367 (2010).</li><li>Besenius, P., Heynens, J. L. M., Straathof, R., Nieuwenhuizen, M. M. L., Bomans, P. H. H., Terreno, E., Aime, S., Strijkers, G. J., Nicolay, K., Meijer, E. W. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Paramagnetic+self-assembled+nanoparticles+as+supramolecular+MRI+contrast+agents.">Paramagnetic self-assembled nanoparticles as supramolecular MRI contrast agents.</a> Contrast Media Mol. Imaging. , (2012).</li></ol>

ब्याज की कोई संघर्ष की घोषणा की.

स्वयं कोडांतरण discotic इस योगदान में (तृतीय) जी.डी. DTPA जटिल युक्त चर्चा amphiphiles जांच के अंतर्गत वर्तमान उपन्यास चुंबकीय अनुनाद इमेजिंग (एमआरआई) एजेंटों कि tunable के उत्सर्जन को समय के साथ उच्च विपरीत गठबंधन के रूप में 15 इसलिए, उनके विवरण हैं. आत्म - विभिन्न परिस्थितियों में व्यवहार और उनके स्थिरता कोडांतरण महत्वपूर्ण महत्व के हैं. स्पेक्ट्रोस्कोपी का संयोजन (सीडी और एनएमआर), (SAXS) बिखरने और माइक्रोस्कोपी (क्रायो - मंदिर) तकनीक का गठन संरचनाओं के दृश्य और उनके thermodynamic के मापदंडों की मात्रा का ठहराव की अनुमति देता है. तकनीक के इस संयोजन आम तौर पर अध्ययन प्रणाली में तरजीही पेचदार भावना के रूप में लंबे समय के रूप में स्वयं कोडांतरण अणुओं के लिए लागू है - बाएँ और दाएँ हाथ के circularly polarized प्रकाश के अवशोषण में एक अंतर की अनुमति देता है.

<table border="1"><tbody><tr><td> अभिकर्मक / उपकरण का नाम </td><td> कंपनी </td><td> सूचीपत्र संख्या </td><td> टिप्पणियाँ </td></tr><tr><td> BTA-जी.डी. (तृतीय) के DTPA </td><td></td><td></td><td> घर में निर्मित </td></tr><tr><td> BTA-Y (तृतीय) के DTPA </td><td></td><td></td><td> घर में निर्मित </td></tr><tr><td> सीडी स्पेक्ट्रोस्कोपी </td><td> Jasco </td><td> Jasco spectropolarimeter 815 - जम्मू </td><td></td></tr><tr><td> एनएमआर </td><td> Varian </td><td> Varian एकता 500 स्पेक्ट्रोमीटर Inova </td><td> 5 मिमी है Varian की पहचान PFG जांच </td></tr><tr><td> क्रायो - मंदिर </td><td> फी </td><td> cryoTITAN मंदिर </td><td></td></tr><tr><td> SAXS </td><td> डच बेल्जियम यूरोपीय Synchotron विकिरण सुविधा (ESRF) में (BM26B) ग्रेनोबल, फ्रांस में beamline </td><td></td><td&gt; </td></tr></tbody></table>

controlling the size, shape and stability of supramolecular polymers in water

For aqueous based supramolecular polymers, the simultaneous control over shape, size and stability is very difficult1. At the same time, the ability to do so is highly important in view of a number of applications in functional soft matter including electronics, biomedical engineering, and sensors. In the past, successful strategies to control the size and shape of supramolecular polymers typically focused on the use of templates2,3, end cappers4 or selective solvent techniques5. 
Here we disclose a strategy based on self-assembling discotic amphiphiles that leads to the control over stack length and shape of ordered, chiral columnar aggregates. By balancing electrostatic repulsive interactions on the hydrophilic rim and attractive non-covalent forces within the hydrophobic core of the polymerizing building block, we manage to create small and discrete spherical objects6,7. Increasing the salt concentration to screen the charges induces a sphere-to-rod transition. Intriguingly, this transition is expressed in an increase of cooperativity in the temperature-dependent self-assembly mechanism, and more stable aggregates are obtained. 
For our study we select a benzene-1,3,5-tricarboxamide (BTA) core connected to a hydrophilic metal chelate via a hydrophobic, fluorinated L-phenylalanine based spacer (Scheme 1). The metal chelate selected is a Gd(III)-DTPA complex that contains two overall remaining charges per complex and necessarily two counter ions. The one-dimensional growth of the aggregate is directed by &pi;-&pi; stacking and intermolecular hydrogen bonding. However, the electrostatic, repulsive forces that arise from the charges on the Gd(III)-DTPA complex start limiting the one-dimensional growth of the BTA-based discotic once a certain size is reached. At millimolar concentrations the formed aggregate has a spherical shape and a diameter of around 5 nm as inferred from 1H-NMR spectroscopy, small angle X-ray scattering, and cryogenic transmission electron microscopy (cryo-TEM). The strength of the electrostatic repulsive interactions between molecules can be reduced by increasing the salt concentration of the buffered solutions. This screening of the charges induces a transition from spherical aggregates into elongated rods with a length &gt; 25 nm. Cryo-TEM allows to visualise the changes in shape and size. In addition, CD spectroscopy permits to derive the mechanistic details of the self-assembly processes before and after the addition of salt. Importantly, the cooperativity -a key feature that dictates the physical properties of the produced supramolecular polymers- increases dramatically upon screening the electrostatic interactions. This increase in cooperativity results in a significant increase in the molecular weight of the formed supramolecular polymers in water.

Watch this Scientific Journal Video about Controlling the Size, Shape and Stability of Supramolecular Polymers in Water at JoVE.com

Controlling the Size, Shape and Stability of Supramolecular Polymers in Water

इस प्रयोग का लक्ष्य निर्धारित करने के लिए और आकार, आकार और पानी में स्वयं इकट्ठे discotic, amphiphiles की स्थिरता को नियंत्रित करने के लिए है. नियंत्रण के ऐसे स्तर जलीय आधारित supramolecular पॉलिमर के लिए बहुत मुश्किल है. हम दोनों प्रतिकारक और आकर्षक बातचीत का उपयोग कर रणनीति लागू होते हैं. प्रयोगात्मक तकनीक लागू करने के लिए इस प्रणाली विशेषताएँ मोटे तौर पर लागू होते हैं.

आकार, और जल में Supramolecular पॉलिमर के आकार की स्थिरता नियंत्रण

For aqueous based supramolecular polymers, the simultaneous control over shape, size and stability is very difficult1. At the same time, the ability to do ...

Research

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Engineering

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Solid-state nanopores have emerged as a versatile tool for the characterization of single biomolecules such as nucleic acids and proteins1. However, the ...

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Horizontal and vertical liquid bridges are simple and powerful tools for exploring the interaction of high intensity electric fields (8-20 kV/cm) and ...

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बर्फ जनरेशन और गर्मी और बड़े पैमाने नमकीन पानी की एक ठंडा स्नान करने के लिए परिचय पानी के हस्तांतरण घटना

We demonstrate a method for the study of the heat and mass transfer and of the freezing phenomena in a subcooled brine environment. Our experiment showed ...

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एक उच्च परिशुद्धता रास्ते में सीमेंट पेस्ट के पानी में घुलनशील क्लोराइड वितरण का पता लगाने

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Uniform and size-controllable poly (ethylene glycol) diacrylate (PEGDA) droplets could be produced via the flow focusing process in a microfluidic device. ...

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के पास एक प्रेरण-गर्म छोटे चुंबकीय क्षेत्र आसपास के पानी के लिए अवरक्त तापमान माप तकनीक

A technique to measure the temperature of water and non-turbid aqueous media surrounding an induction-heated small magnetic sphere is presented. This ...

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Azlactone-कार्यात्मक ब्लॉक सह पॉलिमर के ब्रश की तरह और Crosslinked फिल्मों के साथ प्रतिक्रियाशील सतहों बनाना

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