Name: terahertz microfluidic sensing using a parallel-plate waveguide sensor
Uploaded: 2012-08-30T13:00:00
Description: Watch this Scientific Journal Video about Terahertz Microfluidic Sensing Using a Parallel-plate Waveguide Sensor at JoVE.com

该项目是支持的，部分由美国国家科学基金会和空军研究实验室通过接触程序。

1。传感器的设计与制造<ol><li>设计一个与一个或多个集成电路的空腔（或“槽”）的平行板波导。请参阅图1和图2。几何可以基于我们以前的出版物8,9中给出的或专门设计用于特定的应用。总的指导原则的建议： <ol><li>板间隔：在这个实验中的板间距为1mm的用于有效地耦合到TE1模式，而不需要特殊的光学。它还确保单模传播在感兴趣的频率。当使用其他的板间?...

<ol>
	<li>Kuswandi, B., Nuriman, ., Huskens, J., Verboom, W. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Optical+sensing+systems+for+microfluidic+devices:+A+review.">Optical sensing systems for microfluidic devices: A review.</a> Ana. Chim. Acta. 601, 141-155 (2007).</li><li>Zhu, H., White, I. M., Suter, J. D., Zourob, M., Fan, X. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Integrated+refractive+index+optical+ring+resonator+detector+for+capillary+electrophoresis.">Integrated refractive index optical ring resonator detector for capillary electrophoresis.</a> Anal. Chem. 79, 930-937 (2007).</li><li>Kurt, H., Citrin, D. S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Coupled-resonator+optical+waveguides+for+biochemical+sensing+of+nanoliter+volumes+of+analyte+in+the+terahertz+region.">Coupled-resonator optical waveguides for biochemical sensing of nanoliter volumes of analyte in the terahertz region.</a> Appl. Phys. Lett. 87, 241119 (2005).</li><li>Debus, C., Bolivar, P. H. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Frequency+selective+surfaces+for+high+sensitivity+terahertz+sensing.">Frequency selective surfaces for high sensitivity terahertz sensing.</a> Appl. Phys. Lett. 91, 184102 (2007).</li><li>Harsha, S. S., Laman, N., Grischkowsky, D. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=High-Q+terahertz+Bragg+rsonances+within+a+metal+parallel+plate+waveguide.">High-Q terahertz Bragg rsonances within a metal parallel plate waveguide.</a> Appl. Phys. Lett. 94, 091118 (2009).</li><li>Mendis, R., Mittleman, D. M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Comparison+of+the+lowest-order+transverse-electric+(TE1)+and+transverse-magnetic+(TEM)+modes+of+the+parallel-plate+waveguide+for+terahertz+pulse+applications.">Comparison of the lowest-order transverse-electric (TE1) and transverse-magnetic (TEM) modes of the parallel-plate waveguide for terahertz pulse applications.</a> Optics Express. 17, 14839-14850 (2009).</li><li>Mendis, R., Mittleman, D. M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=An+investigation+of+the+lowest-order+transverse-electric+(TE1)+mode+of+the+parallel-plate+waveguide+for+THz+pulse+propagation.">An investigation of the lowest-order transverse-electric (TE1) mode of the parallel-plate waveguide for THz pulse propagation.</a> JOSA B. 26, A6-A13 (2009).</li><li>Astley, V., McCracken, B., Mendis, R. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Analysis+of+rectangular+resonant+cavities+in+terahertz+parallel-plate+waveguides.">Analysis of rectangular resonant cavities in terahertz parallel-plate waveguides.</a> Opt. Lett. 36, 1452 (2011).</li><li>Mendis, R., Astley, V., Liu, J., Mittleman, D. M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Terahertz+microfluidic+sensor+based+on+a+parallel-plate-waveguide+resonant+cavity.">Terahertz microfluidic sensor based on a parallel-plate-waveguide resonant cavity.</a> Appl. Phys. Lett. 95, 171113 (2009).</li><li>Astley, V., Reichel, K., Jones, J., Mendis, R. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Terahertz+multichannel+microfluidic+sensor+based+on+parallel-plate+waveguide+resonant+cavities.">Terahertz multichannel microfluidic sensor based on parallel-plate waveguide resonant cavities.</a> Appl. Phys. Lett. , (2012).</li></ol>

应当指出，只是在空腔谐振频率确定被测液体的折射率，而不是在很宽的带宽。这具有几个显着的优点。首先，虽然我们的测量已表征的目的使用的宽带太赫兹源，也可以建立一个等效的传感系统与一个单一的频率THz源与只有一个有限的程度的频率可调谐性，一种方法，可以是便宜得多，并更紧凑。其次，感测的方法可以被并行化，通过将多个槽成一个单一的波导。10，每个槽有一个稍微...

<table border="1"><tbody><tr><td> 的试剂的名称 </td><td> 公司 </td><td> 目录编号 </td><td> 评论（可选） </td></tr><tr><td> 10μl注射器</td><td>汉密尔顿</td><td> 80314 </td><td>高精密注射</td></tr><tr><td>液态烷烃</td><td> Acros Organics公司</td><td></td><td>样品进行校准和测试</td></tr><tr><td></td><td></td><td></td><td>没有特定的设备是必需的。合适的试验材料和溶剂留下实验者的酌情决定。此过程中使用的高精度的注射器中列出在下面的表中，但实验者可能希望使用一个不同的卷或设计的注射器，包括数字注射器以提高精度。本实验中使用的测试烷烃也列出。 </td></tr></tbody></table>

terahertz microfluidic sensing using a parallel-plate waveguide sensor

折射率（RI）传感是一个功能强大的微流体样品进行了广泛的可能的传感器设计，如干涉仪和谐振器1,2的鉴定，检测和监测的无创性和无标记检测技术。大多数现有的RI传感应用集中于生物材料在水溶液中，在可见光和红外的频率，如DNA杂交和基因组测序。在太赫兹频率，应用程序，包括质量控制，监测工业生产过程和传感与检测涉及非极性材料的应用。 折射率传感器在太赫兹政权存在一些潜在的设计，包括光子晶体波导，不对称开口环谐振器，并整合成平行板波导的光子带隙结构。这些设计是基于光学谐振器，如戒指或空洞。这些结构的谐振频率依赖于内或周围的谐振器的材料的折射率。通过监测在谐振频率的变化的样品的折射率可以被准确地测量，而这反过来又可以用来确定一个材料，监测污染或稀释等我们在这里使用这种传感器的设计是基于一个简单的平行板波导6,7。到一个谐振腔（ 图1和图2）的一个面作为加工的矩形槽。当被耦合到的最低阶横向电（TE）模式的波导管中传播的太赫兹辐射，其结果是与一个可调谐的谐振频率的槽6,8的几何形状是依赖于一个单一的强共振特性。该槽可填充有导致移位在所观察到的谐振频率依赖于液体的量的非极性液体的微流体样品的uid中的槽和其折射率9。 我们的技术具有比其他的太赫兹波在它的简单的技术，无论是在制造和实施的优点，因为该过程可以用标准的实验室设备来完成，而不需要一个干净的房间或任何特殊的制造或实验技术。它也可以很容易地扩展到多通道操作通过掺入的多个槽10。在这个视频中，我们将介绍完整的实验过程中，从设计的传感器的数据分析和测定样品折射率。

Watch this Scientific Journal Video about Terahertz Microfluidic Sensing Using a Parallel-plate Waveguide Sensor at JoVE.com

Terahertz Microfluidic Sensing Using a Parallel-plate Waveguide Sensor

实施折射率传感器的基础上的带槽的平行板波导几何的太赫兹频率的程序在这里被描述。通过监测的波导结构的谐振频率的移位，该方法产生的一个小体积的液体的折射率测量

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