Name: non-invasive assessment of microvascular and endothelial function
Uploaded: 2013-01-29T12:00:00
Description: Watch this Scientific Journal Video about Non-invasive Assessment of Microvascular and Endothelial Function at JoVE.com

这项工作是由Grant的奖数R01HL096593和K23HL72825从国家心脏，肺和血液研究所的支持。的内容是纯粹的托马斯杰斐逊大学的责任，并不一定代表国家心脏，肺和血液研究所和美国国立卫生研究院的官方意见。

病例报告 （如适用）：不适用，这仍然是一个实验的研究过程，尚未应用于临床。 诊断，评估和计划 （必填，如果适用）：不适用，这仍然是一个实验的研究过程，尚未应用于临床。 过程 （必填）：这部分应包括有关程序一步一步的描述，下面的指导方针。 1。毛细管显微镜（ 图1）</s...

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毛细管显微镜（毛细血管显微镜）的毛细管结构是一个非标准的措施。然而，目前有没有为直接毛细管structure.Furthermore评估的标准方法，毛细血管显微镜已被广泛用于直接评价capillarydensity发表的作品，12日，13日，10日，11日，14日至18日在大，越来越多的。此外，我们已经证实了的毛细血管显微镜技术的关联甲襞微循环的研究结果与前臂血流，血管功能的一个行之有效的措施，10日，11?...

non-invasive assessment of microvascular and endothelial function

作者们利用甲襞微循环和前臂血流技术调查的微血管功能障碍在心血管疾病的发病机制中的作用。毛细管显微镜是一种非侵入性的，相对廉价的直接可视化的微循环的方法。毛细管招聘百分比评估，将毛细血管密度的增加引起的闭塞后反应性充血（闭塞后反应性充血毛细血管密度减去基线毛细血管密度），最大毛细血管密度（被动静脉阻塞的过程中观察到的）。百分比灌注毛细血管代表所有的毛细血管目前，灌注功能活跃，比​​例的计算方法是将闭塞后反应性充血的毛细血管密度最大的毛细血管密度。两者％的毛细管招聘和百分之灌注毛细血管反映毛细血管功能。前臂血流（FBF）技术公关ovides接受血管内皮功能的非侵入性的措施：该比率FBF 最高 / FBF 碱作为血管舒张的估计值，计算除以四个FBF由四个FBF 基值的平均值的最大值的平均值。前臂血管阻力最大的血管扩张（FVR 最大值 ）计算的平均动脉压（MAP）除以FBF 最大 。甲襞微循环和前臂技术，易于接受的患者，可以学得很快。 的微血管和内皮细胞的功能，使用本文介绍的方法可能有未来效用在临床病人的心血管疾病的危险减贫战略措施。正如我们所发表的报告表明，微血管和内皮功能障碍被发现在初始阶段包括高血压前期，高血压，血管和内皮细胞功能的措施最终可能会有助于早期识别，终末期血管病变的危险分层和预防，其潜在的致命后果。

在血压正常和高血压个体之间的微血管的外观的差异是显而易见的，通过比较图4和图5。组织良好的行中的血压正常的个体中， 图4示出了典型的网络直毛细血管。相比之下， 图5显示了一个弄乱模式，皱缩，卷曲的毛细血管。 作者有持续的兴趣的微血管功能障碍在心血管疾病的发病机制中的作用。在他们的第一NIH / NHLBI资助?...

Watch this Scientific Journal Video about Non-invasive Assessment of Microvascular and Endothelial Function at JoVE.com

Non-invasive Assessment of Microvascular and Endothelial Function

毛细管显微镜是一种非侵入性的，相对廉价的直接可视化的微循环的方法。前臂血流技术提供接受血管内皮功能的非侵入性的措施。

非侵入性的评估微血管和内皮功能

The authors have utilized capillaroscopy and forearm blood flow techniques to investigate the role of microvascular dysfunction in pathogenesis of ...

Research

JoVE Journal

Medicine

Non-invasive Optical Measurement of Cerebral Metabolism and Hemodynamics in Infants

婴幼儿的脑代谢和血流动力学的非侵入式光学测量

Perinatal brain injury remains a significant cause of infant mortality  and morbidity, but there is not yet an effective bedside tool that can  accurately ...

科研

医学

Murine Spinotrapezius Model to Assess the Impact of Arteriolar Ligation on Microvascular Function and Remodeling

小鼠Spinotrapezius模型来评估的影响小动脉结扎​​术，微血管功能与重塑

The murine spinotrapezius is a thin, superficial skeletal support muscle that extends from T3 to L4, and is easily accessible via dorsal skin incision. ...

Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence

小鼠模型的非侵入性成像检测和监测卵巢癌复发

Epithelial ovarian cancer is the most lethal gynecologic malignancy in the United States. Although patients initially respond to the current standard of ...

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology

方法论方法血管功能和形态的非侵入性评估

The endothelium is the innermost lining of the vasculature and is involved in the maintenance of vascular homeostasis.  Damage to the endothelium may ...

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice

新的治疗肠道病变的疗效，使用活体小鼠的串行内镜成像的非侵入性评估

Animal models of inflammatory bowel disease (IBD) and colorectal cancer (CRC) have provided significant insight into the cell intrinsic and extrinsic ...

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

血管内皮功能的超声评估：血流介导的舒张试验的技术指导原则

Cardiovascular disease is the primary cause of mortality and a major cause of disability worldwide. The dysfunction of the vascular endothelium is a ...

Assessment of Human Adipose Tissue Microvascular Function Using Videomicroscopy

应用 Videomicroscopy 评价人脂肪组织微血管功能

While obesity is closely linked to the development of metabolic and cardiovascular disease, little is known about mechanisms that govern these processes. ...

Assessment of Kidney Function in Mouse Models of Glomerular Disease

小鼠肾小球疾病模型肾脏功能的评价

The use of murine models to mimic human kidney disease is becoming increasingly common. Our research is focused on the assessment of glomerular function ...

Non-invasive Assessment of Dorsiflexor Muscle Function in Mice

小鼠肌功能的无创评价

Assessment of skeletal muscle contractile function is an important measurement for both clinical and research purposes. Numerous conditions can negatively ...

A Computerized Functional Skills Assessment and Training Program Targeting Technology Based Everyday Functional Skills

以基于技术的日常功能技能为目标的计算机化功能技能评估和培训计划

Today, many functional skills are technology-based, so development of a technology-based training program has broad importance. Here we present a ...