Name: non-invasive assessment of microvascular and endothelial function
Uploaded: 2013-01-29T12:00:00
Description: Watch this Scientific Journal Video about Non-invasive Assessment of Microvascular and Endothelial Function at JoVE.com

Questo lavoro è stato sostenuto con i numeri di assegnazione del contributo e R01HL096593 K23HL72825 dal National Heart, Lung, and Istituto di Sangue. Il contenuto è di esclusiva responsabilità della Thomas Jefferson University e non rappresentano necessariamente le opinioni ufficiali del National Heart, Lung, and Istituto di Sangue o il National Institutes of Health.

Caso Presentazione (richiesto, se del caso): NA, questo è ancora una procedura di ricerca sperimentale, non ancora utilizzato nella pratica clinica. Diagnosi, valutazione, e Piano (richiesta, se del caso): NA, questo è ancora una procedura di ricerca sperimentale, non ancora utilizzato nella pratica clinica. Procedura (richiesto): Questa parte dovrebbe includere uno step-by-step descrizione delle relative proce...

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Capillaroscopia (microscopia capillare) è un non-standard misura della struttura capillare. Tuttavia, attualmente, non esistono metodi standard per la valutazione diretta del capillare structure.Furthermore, microscopia capillare è stato ampiamente utilizzato per la valutazione diretta di capillarydensity in un corpo grande e crescente di lavoro pubblicato 12, 13, 10, 11, 14-18 . Inoltre, abbiamo convalidato la tecnica di microscopia capillare, correlando i risultati con capillaroscopia flusso sanguigno del...

non-invasive assessment of microvascular and endothelial function

Gli autori hanno utilizzato capillaroscopia e l&#39;avambraccio tecniche per il flusso del sangue per indagare il ruolo della disfunzione microvascolare nella patogenesi della malattia cardiovascolare. Capillaroscopia è un non-invasiva, metodo relativamente poco costoso per la visualizzazione diretta del microcircolo. Assunzione cento capillare viene valutata dividendo l&#39;aumento della densità capillare indotta da postocclusive iperemia reattiva (postocclusive iperemia reattiva densità capillare minus densità basale capillare), dalla densità massima capillare (osservata durante occlusione venosa passiva). Cento capillari perfusi rappresenta la proporzione di tutti i presenti capillari che vengono perfuse (funzionalmente attiva), ed è calcolato dividendo postocclusive iperemia reattiva densità capillare per la densità massima capillare. Entrambi reclutamento capillare per cento e per cento capillari perfusi riflettere il numero di capillari funzionale. Il flusso ematico dell&#39;avambraccio (FBF) tecnica di provides accettata non invasive misure della funzione endoteliale: Il rapporto FBF max / FBF base è calcolata come una stima della vasodilatazione, dividendo la media dei quattro valori FBF max per la media dei quattro valori di base FBF. Resistenza vascolare dell&#39;avambraccio a vasodilatazione massima (FVR max) viene calcolato come la pressione arteriosa media (MAP) diviso per FBF max. Sia la capillaroscopia e le tecniche di avambraccio sono facilmente accettabili per i pazienti e può essere imparato in fretta. La funzione endoteliale microvascolare e le misure ottenute utilizzando le metodologie descritte in questo documento possono avere utilità futura clinici dei pazienti cardiovascolari rischio-strategie di riduzione. Come abbiamo pubblicato rapporti che dimostrano che la disfunzione endoteliale microvascolare e si trovano nelle fasi iniziali di ipertensione tra cui pre-ipertensione, le misure di funzione endoteliale microvascolari e può eventualmente aiutare nella identificazione precoce, Rischio-stratificazione e la prevenzione di stadio terminale patologia vascolare, con le sue conseguenze potenzialmente fatali.

Differenze nella comparsa del microcircolo tra individui normotesi e ipertesi sono evidenti confrontando le figure 4 e 5. Figura 4 mostra la rete, tipiche dei capillari in righe ben organizzati in un individuo normotesi. Al contrario, la Figura 5 mostra un modello più scomposta di ristretto, a spirale capillari. Gli autori hanno interesse in corso nel ruolo di disfunzione microvascolare nella patogenesi della malattia cardiovascolare. Nel l...

Watch this Scientific Journal Video about Non-invasive Assessment of Microvascular and Endothelial Function at JoVE.com

Non-invasive Assessment of Microvascular and Endothelial Function

Capillaroscopia è un non-invasiva, metodo relativamente poco costoso per la visualizzazione diretta del microcircolo. Il sangue tecnica dell&#39;avambraccio flusso fornisce accettate non invasive misure della funzione endoteliale.

La valutazione non invasiva della funzione endoteliale e microvascolare

The authors have utilized capillaroscopy and forearm blood flow techniques to investigate the role of microvascular dysfunction in pathogenesis of ...

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