Name: non-invasive assessment of microvascular and endothelial function
Uploaded: 2013-01-29T12:00:00
Description: Watch this Scientific Journal Video about Non-invasive Assessment of Microvascular and Endothelial Function at JoVE.com

この作品は、国立心臓、肺、血液研究所からグラント賞番号R01HL096593とK23HL72825によってサポートされていました。内容はもっぱらトーマスジェファーソン大学の責任であり、必ずしも国立心臓、肺、血液研究所や国立衛生研究所の公式見解を示すものではありません。

ケースプレゼンテーション （必要に応じて、該当する場合）：NA、これはまだ実験的な研究の手順ですが、まだ臨床的に使用されていません。 診断、評価、及び計画 （該当する場合は、必須）：NAは、これはまだ、まだ臨床的に使用されていない実験的な研究の手順です。 手順 （必須）：この部分は、以下?...

<ol>
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Capillaroscopy（毛細管顕微鏡）は毛細管構造の非標準的な尺度である。しかし、現在、キャピラリーstructure.Furthermoreを直接評価するための標準的な方法はありません、毛細血管顕微鏡は広く出版された仕事12、13、10、11、14から18の大規模で成長し、体内のcapillarydensityの直接評価に用いられてきた。さらに、当社は、前腕血流量、血管機能の十分に確立された測定、10、11とcapilla...

non-invasive assessment of microvascular and endothelial function

著者らは、心血管疾患の病因に微小血管機能障害の役割を調べるためにcapillaroscopyと前腕の血流のテクニックを利用してきた。 Capillaroscopyは直接微小循環を可視化するための非侵襲的、比較的安価な方法論です。パーセントキャピラリー募集は最大の毛細血管密度（受動的な静脈閉塞中に観察された）により、postocclusive反応性充血（postocclusive反応性充血毛細血管密度マイナス基線毛細血管密度）によって誘導される毛細血管密度の増加を分割することにより評価される。毛細血管の灌流％が（機能的に活性な）灌流されており、最大の毛細血管密度によってpostocclusive反応性充血毛細血管密度で割って計算されているすべての毛細血管に存在する割合を表しています。パーセントキャピラリー募集およびパーセントはどちらも毛細血管が機能して毛細血管の数を反映して灌流した。前腕血流量（FBF）技術PRovidesは内皮機能の非侵襲的な措置を受け入れ：FBF比の最大値 / FBF ベースは 4 FBF ベース値の平均で4 FBF 最大値の平均値で割って、血管拡張作用の推定値として計算されます。最大の血管拡張（FVR MAX）における前腕血管抵抗はFBF マックスで割った平均動脈圧（MAP）として計算されます。 capillaroscopyと前腕の両技術は、患者に容易に許容され、迅速に学習することができます。 微小血管および血管内皮機能は、本稿で述べた手法を用いて得られたが、臨床患者の心血管リスク低減のための戦略の将来有用性を有することができる測定します。我々は微小血管および内皮機能不全を示すレポートが高血圧前症を含む高血圧の初期の段階で発見され公開されてきたように、微小血管および血管内皮機能指標は、最終的に早期発見に役立つことができるは、その潜在的に致命的な結果を伴う末期の血管病変のリスク層別化と防止、。

正常血圧と高血圧の個体間の微小血管系の外観の違いは、図4と図5を比較することによって容易に明らかである。図4は、正常血圧者でよく整理された行のストレート毛細血管の典型的なネットワークを示しています。これとは対照的に、 図5に縮んだ、コイル状の毛細血管より乱さパターンを示します。 著?...

Watch this Scientific Journal Video about Non-invasive Assessment of Microvascular and Endothelial Function at JoVE.com

Non-invasive Assessment of Microvascular and Endothelial Function

Capillaroscopyは直接微小循環を可視化するための非侵襲的、比較的安価な方法論です。前腕血流技術は、内皮機能の受け入れ、非侵襲的な対策を提供します。

微小血管と内皮機能の非侵襲的評価

The authors have utilized capillaroscopy and forearm blood flow techniques to investigate the role of microvascular dysfunction in pathogenesis of ...

Research

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Medicine

Non-invasive Optical Measurement of Cerebral Metabolism and Hemodynamics in Infants

乳幼児の脳代謝と血行動態の非侵襲的光計測

Perinatal brain injury remains a significant cause of infant mortality  and morbidity, but there is not yet an effective bedside tool that can  accurately ...

Murine Spinotrapezius Model to Assess the Impact of Arteriolar Ligation on Microvascular Function and Remodeling

微小血管機能およびリモデリングに動脈結紮の影響を評価するためにネズミSpinotrapeziusモデル

The murine spinotrapezius is a thin, superficial skeletal support muscle that extends from T3 to L4, and is easily accessible via dorsal skin incision. ...

Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence

卵巣がん再発を検出し、モニターするための非侵襲的イメージングのためのマウスモデル

Epithelial ovarian cancer is the most lethal gynecologic malignancy in the United States. Although patients initially respond to the current standard of ...

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology

血管機能と形態の非侵襲的なアセスメントに方法論的アプローチ

The endothelium is the innermost lining of the vasculature and is involved in the maintenance of vascular homeostasis.  Damage to the endothelium may ...

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice

生きたマウスのシリアル内視鏡イメージングを使用して、腸の異常のための新しい治療の有効性の非侵襲的評価

Animal models of inflammatory bowel disease (IBD) and colorectal cancer (CRC) have provided significant insight into the cell intrinsic and extrinsic ...

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

内皮機能の超音波評価：フロー依存性血管拡張テストの技術ガイドライン

Cardiovascular disease is the primary cause of mortality and a major cause of disability worldwide. The dysfunction of the vascular endothelium is a ...

Assessment of Human Adipose Tissue Microvascular Function Using Videomicroscopy

顕微鏡を用いたひと脂肪組織血管機能評価

While obesity is closely linked to the development of metabolic and cardiovascular disease, little is known about mechanisms that govern these processes. ...

Assessment of Kidney Function in Mouse Models of Glomerular Disease

糸球体疾患のマウス ・ モデルにおける腎機能の評価

The use of murine models to mimic human kidney disease is becoming increasingly common. Our research is focused on the assessment of glomerular function ...

Non-invasive Assessment of Dorsiflexor Muscle Function in Mice

マウスで内がえし筋機能の非侵襲的評価

Assessment of skeletal muscle contractile function is an important measurement for both clinical and research purposes. Numerous conditions can negatively ...

A Computerized Functional Skills Assessment and Training Program Targeting Technology Based Everyday Functional Skills

日常的な機能スキルをベースとした技術を対象とした、コンピュータ化された機能スキル評価とトレーニングプログラム

Today, many functional skills are technology-based, so development of a technology-based training program has broad importance. Here we present a ...