Name: non-invasive assessment of microvascular and endothelial function
Uploaded: 2013-01-29T12:00:00
Description: Watch this Scientific Journal Video about Non-invasive Assessment of Microvascular and Endothelial Function at JoVE.com

Detta arbete stöddes av beviljande av bidrag nummer R01HL096593 och K23HL72825 från National Heart, Lung, and Blood Institute. Innehållet är endast ansvar Thomas Jefferson University och inte nödvändigtvis representerar officiella ståndpunkter National Heart, Lung, and Blood Institute eller National Institutes of Health.

Fall Presentation (krävs, om tillämpligt): NA, detta är fortfarande en experimentell forskning förfarande, som ännu inte använts kliniskt. Diagnos, bedömning och plan (obligatoriskt, om tillämpligt): NA, detta är fortfarande en experimentell forskning förfarande, som ännu inte använts kliniskt. Tillvägagångssätt (obligatoriskt): Denna del bör innehålla en steg-för-steg beskrivning av relevanta f...

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Capillaroscopy (kapillär mikroskopi) är en icke-standard mått på kapillärstruktur. Men nu finns det inga standardmetoder för direkt bedömning av kapillär structure.Furthermore har kapillär mikroskopi använts i stor utsträckning för direkt utvärdering av capillarydensity i en stor och växande mängd publicerade arbeten 12, 13, 10, 11, 14-18 . Dessutom har vi validerat kapillära mikroskopi teknik genom att korrelera capillaroscopy resultat med underarmen blodflöde, en väletablerad mått av vask...

non-invasive assessment of microvascular and endothelial function

Författarna har använt capillaroscopy och underarm tekniker blodflödet för att undersöka vilken roll mikrovaskulära dysfunktion i patogenes av hjärt-kärlsjukdom. Capillaroscopy är en icke-invasiv, relativt billig metod för direkt visualisering av mikrocirkulationen. Procent kapillär rekrytering bedöms genom att dividera ökningen kapillärtäthet inducerad av postocclusive reaktiv hyperemi (postocclusive reaktiv hyperemi kapillär densitet minus baslinjen kapillär densitet), av den maximala kapillär densitet (observerats under passiv venös ocklusion). Procent perfusion kapillärer representerar andelen av alla kapillärer närvarande som perfusion (funktionellt aktiv), och beräknas genom att dividera postocclusive reaktiv hyperemi kapillär densitet av den maximala kapillär densitet. Både procent kapillär rekrytering och procent perfusion kapillärer återspegla antalet funktionella kapillärer. Underarmen blodflödet (FBF) teknik provides accepterade icke-invasiva åtgärder för endotelfunktion: Förhållandet FBF max / FBF bas beräknas som en uppskattning av vasodilatation, genom att dividera medelvärdet av de fyra FBF max värden genom medelvärdet av de fyra FBF grundvärdena. Underarm kärlmotstånd vid maximal vasodilatation (FVR max) beräknas som medelartärtryck (MAP) dividerat med FBF max. Både capillaroscopy och tekniker underarm är lätt accepteras av patienter och kan lära sig snabbt. Den mikrovaskulära och endotelfunktion åtgärder erhålls med de metoder som beskrivs i detta dokument kan vara framtida nyttan i kliniska patienter kardiovaskulära riskbegränsande strategier. Som vi har publicerat rapporter som visar att mikrovaskulära och endoteldysfunktion finns i inledningsskedet av högt blodtryck, inklusive prehypertension kan mikrovaskulära och endotelfunktion stödåtgärderna slutligen i tidig identifiering, Risk-stratifiering och förebyggande av slutstadiet vaskulär patologi, med potentiellt ödesdigra konsekvenser.

Skillnader i utseende mellan mikrovaskulaturen normotensiva och hypertensiva individer är uppenbara genom jämförelse av fig. 4 och 5. Figur 4 visar den typiska nätverket av raka kapillärer i väl organiserade rader i en normotensiva individ. Däremot visar figur 5 ett mer oordning mönster av krympta, hoprullade kapillärer. Författarna har ett pågående intresse i rollen av mikrovaskulära dysfunktion i patogenes av hjärt-kärlsjukd...

Watch this Scientific Journal Video about Non-invasive Assessment of Microvascular and Endothelial Function at JoVE.com

Non-invasive Assessment of Microvascular and Endothelial Function

Capillaroscopy är en icke-invasiv, relativt billig metod för direkt visualisering av mikrocirkulationen. Underarmen blodflödet teknik ger god icke-invasiva åtgärder endotelfunktion.

Icke-invasiv bedömning av Microvascular och endotelfunktion

The authors have utilized capillaroscopy and forearm blood flow techniques to investigate the role of microvascular dysfunction in pathogenesis of ...

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