Name: anatomical reconstructions of the human cardiac venous system using contrast-computed tomography of perfusion-fixed specimens
Uploaded: 2013-04-18T09:00:00
Description: Watch this Scientific Journal Video about Anatomical Reconstructions of the Human Cardiac Venous System using Contrast-computed Tomography of Perfusion-fixed Specimens at JoVE.com

Vi vil gerne anerkende Dionna Gamble, Allison Larson og Katia Torres for assistance med model generering og målinger, Monica Mahre for manuskript assistance, Gary Williams til teknisk bistand, Jerrald Spencer Jr. for assistance med tallene og Fairview Imaging tjenester på University of Minnesota. Finansieringen blev modtaget fra Institut for Engineering i Medicin (University of Minnesota) og dels fra et forsknings-kontrakt med Medtronic Inc.

Procedure Tabel 1 opsummerer de materialer, der anvendes under processen. Figur 1 giver et overblik over processen. 1. Prøve-og Scan Forberedelse <ol><li> Opnå de isolerede humane hjerter friske og efterfølgende perfusion løse dem i 10% buffer formalin i deres slutdiastoliske tilstand. </li><li> Skyl hjerterne, der skal scannes i vand dagen før scanning for at fjerne størstedelen af ​​formalin. </li><li> Inden turen til ...

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Vores laboratorium er ved at udvikle et bibliotek af perfusion-fikserede hjerte prøver til forskellige anatomiske forskningsundersøgelser. Til dato har vi mere end 240 bevarede eksemplarer. De specifikke metoder, vi har anvendt til at fremstille disse prøver er tidligere blevet beskrevet 3.. Den foreliggende undersøgelse beskriver en ny metode til kortlægning af det menneskelige hjerte venøse system og til udvikling af en anatomisk database, som kan anvendes til udformning af hjerte enheder er ansat i k...

anatomical reconstructions of the human cardiac venous system using contrast-computed tomography of perfusion-fixed specimens

En detaljeret forståelse af kompleksitet og relative variabilitet i menneskets hjerte venøse system er afgørende for udviklingen af ​​hjerte-enheder, der kræver adgang til disse fartøjer. For eksempel er hjertets venøse anatomi kendt for at være en af de vigtigste begrænsninger for korrekt levering af hjerte gensynkronisering terapi (CRT) 1 Derfor kan udviklingen af en database over anatomiske parametre for humane kardiale venøse systemer støtte i udformningen af CRT levering enheder til at overvinde en sådan begrænsning. I dette forskningsprojekt blev de anatomiske parametre opnået fra 3D rekonstruktioner af det venøse system ved hjælp af kontrast-computertomografi (CT) scanning og modellering software (Materialise, Leuven, Belgien). Følgende parametre blev vurderet for hver vene: lysbuelængde, tortuousity, der forgrener vinkel, afstand til koronar sinus ostium og en beholder diameter. CRT er en potentiel behandling af Patienser med elektromekanisk dyssynkroni. Ca. 10-20% af patienter med hjertesvigt kan have gavn af CRT 2.. Elektromekanisk dyssynkroni indebærer, at dele af myokardiet aktiveres og aftalen tidligere eller senere end den normale conduction vej af hjertet. I CRT er dyssynchronous områder af myokardiet behandlet med elektrisk stimulering. CRT pacing involverer typisk pacing leads, der stimulerer den højre atrium (RA), højre ventrikel (RV) og venstre ventrikel (LV) til at producere mere gensynkroniseres rytmer. LV bly typisk implanteres i en hjerte-vene med det formål at overlejre den i stedet for seneste myocardial aktivering. Vi mener, at de modeller, opnået, og analyserne heraf vil fremme den anatomiske undervisning for patienter, studerende, klinikere og medicinsk udstyr designere. Metoderne anvendt her, kan også anvendes til at studere andre anatomiske træk ved vores menneskelige hjerte prøver, såsomkranspulsårerne. For yderligere at tilskynde den pædagogiske værdi af denne forskning, har vi delt venøse modeller på vores gratis adgang website: <a href="http://www.vhlab.umn.edu/atlas" target="_blank">www.vhlab.umn.edu / atlas</a> .

Tabel 2 viser den mediane anatomiske parametre for de store hjerte vener til 42 menneskelige hjerte prøver. Alle hjerte prøver indeholdt én posterior interventrikulært vene (PIV) og forreste interventrikulært blodåre (AIV). Nogle prøver indeholdt mere end én posterior vene LV (PVLV), postero-laterale vene (PLV), venstre laterale vene (LLV), og / eller antero-laterale vene (ALV), mens andre hjerter ikke kan have haft en eller to af disse specifikke vener stede. <table border="1"><tbody><tr><t...

Watch this Scientific Journal Video about Anatomical Reconstructions of the Human Cardiac Venous System using Contrast-computed Tomography of Perfusion-fixed Specimens at JoVE.com

Anatomical Reconstructions of the Human Cardiac Venous System using Contrast-computed Tomography of Perfusion-fixed Specimens

Formålet med denne forskning er at genskabe og derefter få adgang til anatomien i menneskets hjerte venøse system ved hjælp af 3D-rekonstruktioner genereret fra kontrast-computertomografi scanninger.

Anatomiske rekonstruktioner af Human Cardiac Venøs System ved hjælp Kontrast-computertomografi af Perfusion-faste Prøver

A detailed  understanding of the complexity and relative variability within the human  cardiac venous system is crucial for the development of cardiac ...

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