Name: magnetically-assisted remote controlled microcatheter tip deflection under magnetic resonance imaging
Uploaded: 2013-04-04T12:00:00
Description: Watch this Scientific Journal Video about Magnetically-Assisted Remote Controlled Microcatheter Tip Deflection under Magnetic Resonance Imaging at JoVE.com

Pallav Kolli，法比奥Settecase，马修·阿芒，和罗伯特·泰勒从加州大学旧金山分校，宾夕法尼亚大学的蒂姆·罗伯茨资金来源美国国立卫生研究院国家心肺血液研究所（NHLBI）奖（M.威尔逊）：1R01HL076486美国社会的神经放射学研究和教育基金会的学者奖（S. Hetts） 美国国立卫生研究院国家生物医学成像和生物工程研究所（NIBIB）奖（S. Hetts）：1R01EB012031

1。弹簧圈的制作<ol><li>获取（ 例如 2.3F捷运科迪斯血管神经导管，雷纳姆，MA）基板市售微导管。 </li><li>确保导管有没有铁的成分，被认为是安全MR-，大小2.3-3.0的范围内F. </li><li>溅射的钛粘附层，然后由一个铜籽晶层，直到1至2毫米外径绝缘管。可能的材料包括聚酰亚胺或氧化铝（Ortech高级陶瓷，萨克拉门托，CA）。 </li><li>电沉积一个正的光致抗蚀剂层，使用希普利的PEPR-2400（目前正在?...

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在这里，我们描述偏转的微导管在MR扫描仪的协议。成功的关键参数是准确的电流和测量应用的偏转角。测量不准确的偏转角是在该协议中最有可能遇到的错误。 MR图像捕获期间水浴实验的角度可能不同于实际值，由于轻微的排列方向不同，该媒介相对于磁体的孔中定位。为了解决这个问题，在未来，可以拍摄的影像通过MR-兼容的光纤相机定位在两个不同的层面。两个MR和摄像头图像的使用，将提...

血管内介入医学用X射线指导导管通过血管治疗的几大疾病，如脑血管瘤，缺血性中风，实体瘤，动脉粥样硬化和心律失常针对超过一百万患者每年全球1导航的工具程序- 5。随着造影剂的使用，导航通过脉管系统通过手动旋转的导管和机械进步实现由干预的手6。然而，通过曲折的小血管周围有许多血管弯曲的导航变得越来越困难，延长的时间才到达目标网站。这就提出了一个问题，对时间敏感的程序，如去除血块阻塞血管。此外，长时间手术增加的辐射剂量，并创造出有潜力的不良事件7-11。然而，血管内的程序下进行磁化C谐振成像可能提供一种解决方案。 强大的均匀磁场的核磁共振成像扫描仪可以利用导管尖端导航遥控12,13。电流施加到导管尖端位于microcoil诱导磁矩小，因为它对准的MRI扫描仪13（ 图1）的孔中，经历了转矩。如果电流在一个单独的线圈被激活，导管尖端可以通过远程控制在一个平面内偏转。如果在导管尖端的三个线圈通电时，可以实现在导管尖端偏转三维。因此，磁推动转向导管有可能增加血管在血管内手术导航的速度和有效性，这可以减少手术时间，改善患者的预后。在这项研究中，我们研究了如果当前应用到microcoil头的血管内导管，可产生可靠的和可控的挠度附加的领导下，指导导管导航研究的初步测试。

<table border="1">
<tbody>
 <tr>
 <td>Name of Reagent/Material</td>
 <td>Company</td>
 <td>Catalog Number</td>
 <td>Comments</td>
 </tr>
 <tr>
 <td>GdDTPA Contrast Media (Magnevist)</td>
 <td>Bayer HealthCare Pharmaceuticals Inc. </td>
 <td>1240340</td>
 <td>McKesson Material Number</td>
 </tr>
 <tr>
 <td>Positive Photoresist</td>
 <td>Shipley</td>
 <td>N/A</td>
 <td>PEPR-2400, Replacement: Dow Chemicals Intervia 3D-P </td>
 </tr>
 <tr>
 <td>Copper Sulfate</td>
 <td>ScienceLab</td>
 <td>SLC3778</td>
 <td>Crystal form</td>
 </tr>
 <tr>
 <td>Sulfuric Acid</td>
 <td>ScienceLab</td>
 <td>SLS1573</td>
 <td>50% w/w solution</td>
 </tr>
 <tr>
 <td>Parrafin Wax</td>
 <td>Carolina</td>
 <td>879190</td>
 <td></td>
 </tr>
 <tr>
 <td>Potassium Carbonate </td>
 <td>Acros Organics</td>
 <td>424081000</td>
 <td></td>
 </tr>
</tbody>
 </table>

magnetically-assisted remote controlled microcatheter tip deflection under magnetic resonance imaging

X线透视引导下血管内的程序有几个显着的限制，包括难以的导管导航和利用电离辐射，可能会被克服MR指导下使用磁性可控的导管。 这项工作的主要目的是开发一种微导管，其尖端使用磁场的MR扫描仪，可以远程控制。该协议的目的是描述的程序申请的microcoil头微导管一贯的，可控的变形。 制作中，采用激光车床光刻技术的一个microcoil到聚酰亚胺头的血管内导管。一个1.5-T磁共振系统的稳态自由进动（SSFP）测序的指导下， 在体外试验中进行水浴中和容器幻象。不同量的电流施加到线圈的微型导管，以产生测量sureable提示的挠度和导航的血管幻影。 此设备的发展提供了一个平台，为未来的测试和革命性的血管内介入MRI环境的机会。

应该观察到从协议如上所述，在0度和90度之间的偏转角，从应用程序同时交付到一个合并的螺线管和亥姆霍兹线圈微型导管系统（ 图2E）的两个线圈的电流为50-300毫安。应当施加的电流的增加导致在微型导管的偏转角的增加，电流的极性反转而导致的偏转与正电流在完全相反的方向上所观察到的（ 图5A-5C）。的偏转角，但是，是依赖于几个参数。施加的电流的量，并在电...

Watch this Scientific Journal Video about Magnetically-Assisted Remote Controlled Microcatheter Tip Deflection under Magnetic Resonance Imaging at JoVE.com

Magnetically-Assisted Remote Controlled Microcatheter Tip Deflection under Magnetic Resonance Imaging

电流施加到血管内的微导管通过激光车床光刻microcoil小费可以实现可控挠度根据磁共振（MR）的指导，这可以改善在各种血管内手术导航中的​​脉管系统的速度和疗效。

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