Name: magnetically-assisted remote controlled microcatheter tip deflection under magnetic resonance imaging
Uploaded: 2013-04-04T12:00:00
Description: Watch this Scientific Journal Video about Magnetically-Assisted Remote Controlled Microcatheter Tip Deflection under Magnetic Resonance Imaging at JoVE.com

Pallav Kolli, Fabio Settecase, Matthew Amans, og Robert Taylor fra UCSF, Tim Roberts fra University of Pennsylvania Finansieringskilder NIH National Heart Lung Blood Institute (NHLBI) Award (M. Wilson): 1R01HL076486 American Society of neuroradiologi Forskning og Education Foundation Scholar Award (S. Hetts) NIH National Institute of Biomedical Imaging and Bioengineering (NIBIB) Award (S. Hetts): 1R01EB012031

1. Microcoil Fabrication <ol><li> Opnå en kommercielt tilgængelig mikrokateter (f.eks 2.3F Rapid Transit Cordis neurovaskulær Kateter, Raynham, MA) til et substrat. </li><li> Sørg katetre har ingen jernholdige komponenter, anses MR-sikker, og varierer i størrelse 2,3-3,0 F. </li><li> Sputter en titanium klæbelag efterfulgt af en kobber frø lag til at være et 1 til 2 mm OD isolerende rør. Mulige materialer indbefatter polyimid eller aluminiumoxid (Ortech Advanced Ceramics, Sacramento, CA). </li><li> E...

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Her beskriver vi protokollen for afbøjning af en mikrokateter i en MR-skanner. De væsentligste parametre for succes er korrekte anvendelse af strøm og måling af afbøjning vinkel. Unøjagtig måling af udslag vinkel er den mest sandsynlige fejl opstod i denne protokol. Vinklerne fanget i MR-billeder i vandbadet eksperimentet kan afvige fra de faktiske værdier på grund af små forskelle i orienteringen, hvorved mediet er placeret i forhold til boringen i magneten. For at løse dette problem i fremtiden, kan billede...

Intravaskulært procedurer udføres i interventionel medicin use x-ray vejledning som et redskab til kateter navigation gennem vaskulatur til at behandle flere store sygdomme, såsom hjerne aneurisme, iskæmisk slagtilfælde, solide tumorer, atherosklerose og hjertearytmier målrettet over en million patienter om året på verdensplan 1 - 5. Ved anvendelse af kontrastmidler, der navigation gennem vaskulaturen opnås ved manuel rotation af katetret og mekaniske fremføring af interventionistiske hånd 6. Men navigation gennem små snoede blodkar omkring mange vaskulære sving bliver stadig vanskeligere, forlængede tiden før den når emnet site. Dette udgør et problem for tidsfølsomme procedurer, såsom fjernelse af en blodprop i en okkluderede blodkar. Derudover langvarige procedurer øger strålingsdosis og skabe potentiale for bivirkninger 7-11. Imidlertid endovaskulære procedurer udføres under Magnetic resonansbilleddannelse kan være en løsning. Den stærke homogent magnetfelt af en MR-scanner kan udnyttes til kateterspidsen navigation med fjernbetjening 12,13. Strøm påført en microcoil placeret ved en kateterspids inducerer en lille magnetisk moment, som oplever et drejningsmoment, som det ligger på linie med boringen i MR-scanner 13 (figur 1). Hvis elektrisk strøm er aktiveret i en enkelt spole, kan kateterspidsen blive afbøjet i et plan ved fjernstyring. Hvis tre spoler på en kateterspids er tilsluttet, kan kateterspidsen afbøjning opnås i tre-dimension. Således magnetisk lettet styring af et kateter har potentiale til at øge hastigheden og effektiviteten af ​​vaskulær sejlads i endovaskulære procedurer, som kan reducere procedure gange og forbedre patienternes resultater. I denne undersøgelse undersøgte vi, hvis strøm påføres en microcoil spids endovaskulær kateter kan producere pålidelige og kontrolleret deflections under MR-vejledning, som foreløbig test af kateter navigation undersøgelser.

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 <td>Name of Reagent/Material</td>
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 <td>GdDTPA Contrast Media (Magnevist)</td>
 <td>Bayer HealthCare Pharmaceuticals Inc. </td>
 <td>1240340</td>
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 <td>PEPR-2400, Replacement: Dow Chemicals Intervia 3D-P </td>
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magnetically-assisted remote controlled microcatheter tip deflection under magnetic resonance imaging

X-ray fluoroskopi-vejledt endovaskulære procedurer har flere væsentlige begrænsninger, herunder vanskelige kateter navigation og anvendelse af ioniserende stråling, der potentielt kan overvindes ved hjælp af en magnetisk styrbare kateter under MR vejledning. Det primære mål med dette arbejde er at udvikle et mikrokateter hvis spids kan fjernstyres ved hjælp af det magnetiske felt i MR-skanner. Denne protokol har til formål at beskrive de procedurer for anvendelse strøm til microcoil spids mikrokateteret at give ensartede og kontrollerbare nedbøjninger. En microcoil blev fremstillet ved hjælp af laser drejebænk litografi på en polyimid spids endovaskulær kateter. In vitro tests blev udført i et vandbad og skib fantom under vejledning af en 1,5-T MR-system ved hjælp af steady-state gratis præcession (SSFP) sekventering. Forskellige mængder af strøm blev påført til spolerne i mikrokateteret til at fremstille MEAsureable tip omlægninger og navigere i vaskulære fantomer. Udviklingen af ​​denne enhed skaber en platform for fremtidig testning og mulighed for at revolutionere den endovaskulære interventionel MRI miljø.

Fra den ovenfor beskrevne protokol, en frigang mellem 0 og 90 grader bør observeres ved anvendelse af 50 til 300 mA strøm leveres samtidig til begge spoler i et kombineret solenoide og Helmholtz spole mikrokateteret (figur 2E). En forøgelse af tilført strøm bør resultere i en forøgelse af mikrokateteret afbøjningsvinkel, mens et omslag i nuværende polaritet bør resultere i deformation i den modsatte retning som observeret med positiv strøm (fig. 5A-5C). Afbøjningsvinklen er ...

Watch this Scientific Journal Video about Magnetically-Assisted Remote Controlled Microcatheter Tip Deflection under Magnetic Resonance Imaging at JoVE.com

Magnetically-Assisted Remote Controlled Microcatheter Tip Deflection under Magnetic Resonance Imaging

Nuværende anvendt på en endovaskulær mikrokateteret med microcoil spids lavet af laser drejebænk litografi kan opnå styrbare udbøjninger under magnetisk resonans (MR) vejledning, som kan forbedre hastigheden og effektiviteten af ​​sejlads af vaskulatur under forskellige endovaskulære procedurer.

Magnetisk Assisted Fjernstyret mikrokateteret Tip Nedbøjning under Magnetic Resonance Imaging

X-ray fluoroscopy-guided  endovascular procedures have several significant limitations, including  difficult catheter navigation and use of ionizing ...

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