Name: a laser-induced mouse model of chronic ocular hypertension to characterize visual defects
Uploaded: 2013-08-14T14:00:00
Description: Watch this Scientific Journal Video about A Laser-induced Mouse Model of Chronic Ocular Hypertension to Characterize Visual Defects at JoVE.com

इस पत्र में निहित काम अमेरिकी स्वास्थ्य सहायता फाउंडेशन (एक्स्ट्रा लार्ज), दृष्टिहीनता को रोकने के लिए अनुसंधान से विलियम एंड मैरी ग्रीव विशेष विद्वान पुरस्कार (एक्स्ट्रा लार्ज), से रोग अनुसंधान के लिए डॉ. डग्लस एच. जॉनसन पुरस्कार द्वारा समर्थित किया गया है दृष्टिहीनता की रोकथाम के लिए इलिनोइस सोसायटी (एचसी) और NIH अनुदान R01EY019034 (एक्स्ट्रा लार्ज).

प्रक्रिया C57BL/6J चूहों (जैक्सन प्रयोगशाला, बार हार्बर, इ) नॉर्थवेस्टर्न विश्वविद्यालय के पशु देखभाल सुविधा में उठाए गए हैं. सभी जानवरों नॉर्थवेस्टर्न विश्वविद्यालय संस्थागत पशु की देखभाल और उ...

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हम जानते हैं कि निरंतर आंख का उच्च रक्तचाप से ऊपर रिपोर्ट माउस आँखों में लेजर रोशनी द्वारा प्रेरित किया जा सकता है. खारा इंजेक्शन मॉडल 18 और नस दाग़ना मॉडल व्यापक microsurgical कौशल की आवश्यकता होती है, जो दो?...

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 <td>Slit Lamp, TOPCON </td>
 <td>Visual Systems Inc</td>
 <td>SL-3E</td>
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a laser-induced mouse model of chronic ocular hypertension to characterize visual defects

अक्सर बुलंद intraocular दबाव (IOP) के साथ जुड़े रोग, अंधापन के प्रमुख कारणों में से एक है. हम मानव उच्च तनाव मोतियाबिंद की नकल करने की आंख का उच्च रक्तचाप के एक माउस मॉडल की स्थापना करने की मांग की. यहाँ लेजर रोशनी कोण बंद उत्प्रेरण, जलीय बहिर्वाह photocoagulate को कॉर्निया किनारी पर लागू होता है. IOP के परिवर्तन लेजर उपचार के पहले और बाद में एक पलटाव टनमीटर उपयोग पर नजर रखी जाती है. एक optomotor व्यवहार परीक्षण दृश्य क्षमता में इसी परिवर्तन को मापने के लिए प्रयोग किया जाता है. लेजर रोशनी के बाद निरंतर IOP ऊंचाई विकसित की है जो एक माउस से प्रतिनिधि परिणाम दिखाया गया है. एक कम दृश्य तीक्ष्णता और विपरीत संवेदनशीलता इस आंख का उच्च रक्तचाप से ग्रस्त माउस में मनाया जाता है. साथ में, हमारे अध्ययन glaucomatous चूहों में neuronal अध: पतन और अंतर्निहित आणविक तंत्र की जांच के लिए एक मूल्यवान मॉडल प्रणाली का परिचय.

जैसा कि प्रक्रियाओं में वर्णित, लेजर रोशनी कोण बंद (चित्रा 1) उत्प्रेरण, जलीय बहिर्वाह photocoagulate को अंगीय क्षेत्र में trabecular meshwork के उद्देश्य से है. हाल lasered आंखों पिछले निष्कर्ष 6 के साथ संगत कोई महत्वप?...

Watch this Scientific Journal Video about A Laser-induced Mouse Model of Chronic Ocular Hypertension to Characterize Visual Defects at JoVE.com

A Laser-induced Mouse Model of Chronic Ocular Hypertension to Characterize Visual Defects

क्रोनिक आंख का उच्च रक्तचाप माउस आँखों में trabecular meshwork के लेजर photocoagulation का उपयोग कर प्रेरित किया जाता है. intraocular दबाव (IOP) लेजर उपचार के बाद कई महीनों के लिए उठाया है. दृश्य तीक्ष्णता और प्रायोगिक पशुओं के विपरीत संवेदनशीलता की कमी optomotor परीक्षण का उपयोग निगरानी कर रहे हैं.

दृश्य दोष विशेषताएँ जीर्ण नेत्र उच्च रक्तचाप के एक लेजर प्रेरित माउस मॉडल

Glaucoma, frequently associated with elevated intraocular pressure (IOP), is one of the leading causes of blindness. We sought to establish a mouse model ...

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Driving Simulation in the Clinic: Testing Visual Exploratory Behavior in Daily Life Activities in Patients with Visual Field Defects

क्लिनिक में सिमुलेशन ड्राइविंग: दृश्य क्षेत्र दोष के साथ रोगियों में दैनिक जीवन की गतिविधियों में दृश्य व्यवहार खोजपूर्ण परीक्षण

Patients suffering from homonymous hemianopia after infarction of the posterior cerebral artery (PCA) report different degrees of constraint in daily ...

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

उच्च नमक आहार और लुईस चूहा में क्रोनिक किडनी रोग प्रेरित करने के लिए नाइट्रिक ऑक्साइड synthase निषेध के साथ संयोजन में 5/6th nephrectomy

Chronic kidney disease (CKD) is a global problem. Slowing CKD progression is a major health priority. Since CKD is characterized by complex derangements ...

Adult Mouse Venous Hypertension Model: Common Carotid Artery to External Jugular Vein Anastomosis.

वयस्क माउस शिरापरक उच्च रक्तचाप आदर्श: बाहरी गले नस सम्मिलन के लिए आम मन्या धमनी।

The understanding of the pathophysiology of brain arteriovenous malformations and arteriovenous fistulas has improved thanks to animal models. A rat model ...

Assessment of Vascular Function in Patients With Chronic Kidney Disease

क्रोनिक किडनी रोग के साथ रोगियों में नाड़ी समारोह का आकलन

Patients with chronic kidney disease (CKD) have significantly increased risk of cardiovascular disease (CVD) compared to the general population, and this ...

A Mouse Model for Laser-induced Choroidal Neovascularization

लेजर प्रेरित Choroidal neovascularization के लिए एक माउस मॉडल

The mouse laser-induced choroidal neovascularization (CNV) model has been a crucial mainstay model for neovascular age-related macular degeneration (AMD) ...

A Magnetic Microbead Occlusion Model to Induce Ocular Hypertension-Dependent Glaucoma in Mice

एक चुंबकीय Microbead आड़ मॉडल चूहे में नेत्र उच्च रक्तचाप पर निर्भर ग्लूकोमा प्रेरित करने के लिए

The use of rodent models of glaucoma has been essential to understand the molecular mechanisms that underlie the pathophysiology of this multifactorial ...

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एक सरल यांत्रिक प्रक्रिया माउस में Limbal स्टेम सेल की कमी से बनाएँ करने के लिए

Limbal stem cell deficiency (LSCD) is a state of malfunction or loss of limbal epithelial stem cells, after which the corneal epithelium is replaced with ...

Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension

क्रोनिक थ्रोम्बोएम्बोलिक पल्मोनरी हाइपरटेंशन के एक बड़े पशु मॉडल में तीव्र सही दिल की विफलता का प्रेरण और फेनोटाइपिंग

The development of acute right heart failure (ARHF) in the context of chronic pulmonary hypertension (PH) is associated with poor short-term outcomes. The ...

Isometric Contractility Measurement of the Mouse Mesenteric Artery Using Wire Myography

माउस के Isometric सिकुड़ना माप Mesenteric धमनी का उपयोग तार Myography

The wire myograph technique is used to assess the contractility of vascular smooth muscles in response to depolarization, GPCR agonists/inhibitors and ...

A Reversible Silicon Oil-Induced Ocular Hypertension Model in Mice

चूहों में एक रिवर्सिबल सिलिकॉन तेल-प्रेरित नेत्र उच्च रक्तचाप मॉडल

Elevated intraocular pressure (IOP) is a well-documented risk factor for glaucoma. Here we describe a novel, effective method for consistently inducing ...