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A Procedure to Study the Effect of Prolonged Food Restriction on Heroin Seeking in Abstinent Rats

DOI :

10.3791/50751-v

November 11th, 2013

November 11th, 2013

10,726 Views

1Department of Psychology, Center for Studies in Behavioural Neurobiology/Groupe de Recherche en Neurobiologie Comportementale, Concordia University

A procedure that allows a demonstration of robust augmentation of drug seeking in food-restricted rats is described. Following heroin self-administration training, rats go through an abstinence period, in a drug-free environment, during which they are mildly food restricted. Drug seeking is then tested in the drug-associated environment.

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