Name: pulse wave velocity testing in the baltimore longitudinal study of aging
Uploaded: 2014-02-07T13:45:00
Description: Watch this Scientific Journal Video about Pulse Wave Velocity Testing in the Baltimore Longitudinal Study of Aging at JoVE.com

这项研究是由院内研究计划的美国国立卫生研究院，国家老龄问题研究所和巴尔的摩纵向研究老龄问题的支持。这种支持的一部分是通过与MEDSTAR研究院的研发合同。标准协议和技术专长是由ATCOR提供。

1。程序<ol><li>通过您的Windows桌面上的快捷方式的图标，双击打开软件。 </li><li>点击病人，激活病人屏幕。 </li><li>要进入一个新的病人到数据库中，单击耐心搜索区域的新建按钮，然后点击Yes按钮确认你想进入一个新的病人。 </li><li>输入患者详细信息，如姓氏，名字，出生日期和性别。点击保存按钮，前进到下一个步骤。 </li><li>点击PWA或PWV按钮来进行测量。如果只有其中的一种模式是可用的?...

<ol>
	<li>Najjar, S. S., Scuteri, A., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Pulse+wave+velocity+is+an+independent+predictor+of+the+longitudinal+increase+in+systolic+blood+pressure+and+of+incident+hypertension+in+the+Baltimore+Longitudinal+Study+of+Aging.">Pulse wave velocity is an independent predictor of the longitudinal increase in systolic blood pressure and of incident hypertension in the Baltimore Longitudinal Study of Aging.</a> J. Am. Coll. Cardiol. 51 (14), 1377-1383 (2008).</li><li>Doonan, R. J., Scheffler, P., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Altered+arterial+stiffness+and+subendocardial+viability+ratio+in+young+healthy+light+smokers+after+acute+exercise.">Altered arterial stiffness and subendocardial viability ratio in young healthy light smokers after acute exercise.</a> PloS one. 6 (10), (2011).</li><li>Laurent, S., Cockcroft, J., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Expert+consensus+document+on+arterial+stiffness:+methodological+issues+and+clinical+applications.">Expert consensus document on arterial stiffness: methodological issues and clinical applications.</a> Eur. Heart J. 27 (21), 2588-2605 (2006).</li><li>Mitchell, G. F., Hwang, S. -. J., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Arterial+stiffness+and+cardiovascular+events:+the+Framingham+Heart+Study.">Arterial stiffness and cardiovascular events: the Framingham Heart Study.</a> Circulation. 121 (4), 505-511 (2010).</li><li>Abbatecola, A. M., Chiodini, P., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Pulse+wave+velocity+is+associated+with+muscle+mass+decline:+Health+ABC+study.">Pulse wave velocity is associated with muscle mass decline: Health ABC study.</a> Age. , (2011).</li><li>Watson, N. L., Sutton-Tyrrell, K., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Arterial+stiffness+and+gait+speed+in+older+adults+with+and+without+peripheral+arterial+disease.">Arterial stiffness and gait speed in older adults with and without peripheral arterial disease.</a> Am. J. Hypertens. 24 (1), 90-95 (2011).</li><li>Mackenzie, I. S., Wilkinson, I. B., Cockcroft, J. R. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Assessment+of+arterial+stiffness+in+clinical+practice.">Assessment of arterial stiffness in clinical practice.</a> QJM. 95 (2), 67-74 (2002).</li><li>O'Rourke, M. F., Pauca, A., Jiang, X. J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Pulse+wave+analysis.">Pulse wave analysis.</a> Br. J. Clin. Pharmacol. 51 (6), 507-522 (2001).</li><li>Stoner, L., Young, J. M., Fryer, S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Assessments+of+arterial+stiffness+and+endothelial+function+using+pulse+wave+analysis.">Assessments of arterial stiffness and endothelial function using pulse wave analysis.</a> Int. J. Vasc. Med. 2012, 903107 (2012).</li><li>Farro, I., Bia, D., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Pulse+wave+velocity+as+marker+of+preclinical+arterial+disease:+reference+levels+in+a+uruguayan+population+considering+wave+detection+algorithms,+path+lengths,+aging,+and+blood+pressure.">Pulse wave velocity as marker of preclinical arterial disease: reference levels in a uruguayan population considering wave detection algorithms, path lengths, aging, and blood pressure.</a> Int. J. Hypertens. 2012, (2012).</li><li>Lakatta, E. G., Wang, M., Najjar, S. S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Arterial+aging+and+subclinical+arterial+disease+are+fundamentally+intertwined+at+macroscopic+and+molecular+levels.">Arterial aging and subclinical arterial disease are fundamentally intertwined at macroscopic and molecular levels.</a> Med. Clin. N. Am. 93 (3), 583-604 (2009).</li><li>Ambrose, M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=.">.</a> Clinical Manual (CVMS) Rev. 2, 1-51 (2011).</li><li>. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Reference+Values+for+Arterial+Stiffness'+Collaboration+Determinants+of+pulse+wave+velocity+in+healthy+people+and+in+the+presence+of+cardiovascular+risk+factors:+'establishing+normal+and+reference+values.">Reference Values for Arterial Stiffness' Collaboration Determinants of pulse wave velocity in healthy people and in the presence of cardiovascular risk factors: 'establishing normal and reference values.</a> Eur. Heart J. 31 (19), 2338-2350 (2010).</li><li>van Bortel, L. M., Laurent, S., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Expert+consensus+document+on+the+measurement+of+aortic+stiffness+in+daily+practice+using+carotid-femoral+pulse+wave+velocity.">Expert consensus document on the measurement of aortic stiffness in daily practice using carotid-femoral pulse wave velocity.</a> J. Hypertens. 30 (3), 445-448 (2012).</li><li>Scuteri, A., Brancati, A., Gianni, W., Assisi, A., Volpe, M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Arterial+stiffness+is+an+independent+risk+factor+for+cognitive+impairment+in+the+elderly:+a+pilot+study.">Arterial stiffness is an independent risk factor for cognitive impairment in the elderly: a pilot study.</a> J. Hypertens. 23 (6), 1211 (2005).</li><li>Khoshdel, A. R., Carney, S. L., Nair, B. R., Gillies, A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Better+management+of+cardiovascular+diseases+by+pulse+wave+velocity:+combining+clinical+practice+with+clinical+research+using+evidence-based+medicine.">Better management of cardiovascular diseases by pulse wave velocity: combining clinical practice with clinical research using evidence-based medicine.</a> Clin. Med. Res. 5 (1), 45-52 (2007).</li></ol>

脉搏波速度（PWV）的测量是分析中央动脉僵硬度在一个相对简单和可重复的方式3一种非侵入性的方法。为了评估PWV，颈动脉（作为替代降主动脉）和股动脉脉搏波形使用的是高保真眼压计收购;延时脉冲波到达两个站点之间估计引用的同时记录心电图波由符合动脉系统3,10的繁殖模型定制设计的计算机软件。这两个采样点之间的距离，然后由该时间延迟划分到在“PWV”11到?...

脉搏波速度（PWV）被认为是动脉僵硬度2的评估的金标准。而不是用于临床在美国，已经在整个欧洲3验证，并广泛地用于临床环境中。改变PWV已与相关心血管疾病的危险因素，如高血压，肥胖，糖耐量异常，血脂异常和。较高的主动脉僵硬度已经与风险增加了首次心血管事件4，肌肉质量下降5，和较慢的步速的科目与外周动脉疾病的相关联。 PWV的评估是通过分析与血液的脉冲从颈动脉行进到股动脉7的转速来实现的。这是一个相对简单的方法具有高度可重现的结果。技术的进步继续简化程序，减少了操作者的依赖，并降低所需的时间的量考试。在我们的实验室中使用该系统生产的SphygmoCorand利用心电图和高保真眼压计，从颈动脉和股动脉搏动采集波形。该软件然后分析这些变量由1来确定速度）估计，该脉冲波需要通过参考压力波到达各动脉站点相对于所述的心电图波形2的定时的颈动脉和股点之间的旅行除以时间）两个站点的预计时间之间的测量距离。该采样点紧密联系起来，在不准确的PWV，限​​制了这种方法的较大血管，如股动脉和颈动脉。除了 ​​确定PWV时，系统可以通过应用传递函数由径向脉冲8这是“中央压力”和压力所产生的波形计算在升主动脉中的压力，在喷射时间最直接影响心脏。此信息可在对左心室以可靠和非侵入性的方式9在动脉系统的效果评估帮助。通过回声跟踪用于血管硬度的检验替代技术，如颈动脉扩张，需要大量的技术专长和比PWV耗费更多的时间。回声跟踪也普遍采用了视频图像分析，因此，这些测量的精度是有限3。其他技术用于检查血管改变包括颈动脉内膜中层厚度（IMT），它提供的结果更密切相关的动脉粥样硬化的进展，虽然获得的横截面和横向图像可以提供颈动脉顺应性的粗近似的评估。这个方法，但是，通过相同的一些约束如上所述的扩张性研究的困扰。随着研究人员继续寻找在各种疾病状态的作用动脉僵硬度的戏剧，PWV的测量可能将继续提供一个定量的和可重复的替代终点。

<table border="0" cellpadding="0" cellspacing="0" width="256">
	<colgroup>
		<col span="4" />
	</colgroup>
	<tbody>
		<tr height="61">
			<td height="61" style="height:61px;width:64px;">SphygmoCor System</td>
			<td style="width:64px;">AtCor&#160;</td>
			<td style="width:64px;">SPT-304, Module EM3</td>
			<td style="width:64px;"></td>
		</tr>
	</tbody>
</table>

pulse wave velocity testing in the baltimore longitudinal study of aging

颈动脉-股动脉脉搏波速度被认为是黄金标准，通过无创方法1获得中央动脉僵硬度的测量。受试者被放置在仰卧位，并允许至少10分钟的考试开始之前悄悄休息。合适的袖带尺寸的选择和使用示波装置获得的血压。一旦一个静息血压已经获得，压力波形被从右侧股动脉和右颈总动脉购入。然后系统会自动计算这两个站点之间的脉冲传输时间（使用颈动脉作为替代降主动脉）。体表测量用于确定由两个采样点之间的脉搏波行进的距离。这个距离，然后由所得的脉搏波传导速度的脉搏传导时间划分。该测量是在一式三份进行，并且平均是用于肛门ysis。

<html><img alt="表1" fo:content-width="5in" fo:src="/files/ftp_upload/50817/50817table1highres.jpg" src="/files/ftp_upload/50817/50817table1.jpg" /> 表1中。 PWV结果都产自米每秒。在健康受试者，这些速度范围可以从一个平均每6.2米/秒（在30科目）至10.9米/秒（在科目70岁及以上），这些数值分别建立在健康人的文章“脉搏波传导速度的决定因素和心血管危险因素的存在：“建立正常的...

Watch this Scientific Journal Video about Pulse Wave Velocity Testing in the Baltimore Longitudinal Study of Aging at JoVE.com

Pulse Wave Velocity Testing in the Baltimore Longitudinal Study of Aging

脉搏波速度（PWV）测量了眼压为基础的系统，测量与动脉压力波会沿着动脉树，通常近似，它需要这一波从降主动脉（使用颈行驶时的速度评估动脉僵硬度动脉作为替代），以股动脉。颈动脉 - 股动脉脉搏波速度提高两到整个成人寿命三倍。

脉搏波传导速度测试老化的巴尔的摩纵向研究中

Carotid-femoral pulse wave velocity is considered the gold standard for measurements of central arterial stiffness obtained through noninvasive ...

Research

Education

JoVE Core

JoVE Journal

Nursing

Medicine

Unit 1

Vital Signs: Pulse

SCIENTISTS IN ACTION

Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD

在动物模型揭示神经，血液，创伤后应激障碍和行为相关因素的生物标志物

Identification of biomarkers representing the evolution of the pathophysiology of Post Traumatic Stress Disorder (PTSD) is vitally important, not only for ...

科研

医学

Orthotopic Aortic Transplantation in Mice for the Study of Vascular Disease

原位主动脉瓣移植在小鼠血管疾病的研究

Vascular procedures involving anastomoses in the mouse are generally thought to be difficult and highly dependent on the skill of the individual surgeon. ...

Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics

透过玻璃看：时间推移显微镜和单细胞的纵向跟踪研究抗癌治疗

The response of single cells to anti-cancer drugs contributes significantly in determining the population response, and therefore is a major contributing ...

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

一个表型养生为用于研究衰老的人类疾病基因牵连转基因小鼠

Age-related diseases are becoming increasingly prevalent and the burden continues to grow as our population ages. Effective treatments are necessary to ...

Ultrasound-based Pulse Wave Velocity Evaluation in Mice

基于超声脉搏波速度评价小鼠

Arterial stiffness can be evaluated by calculating pulse wave velocity (PWV), i.e., the speed with which the pulse wave travels in a conduit vessel. This ...

The Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy (rNAION)

The Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy rNAION

非动脉炎性前部缺血性视神经病变的啮齿动物模型（rNAION）

Nonarteritic anterior ischemic optic neuropathy (NAION) is a focal ischemic lesion of the optic nerve that affects 1/700 individuals throughout their ...

Longitudinal In Vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases

Longitudinal In Vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases

纵<em&gt;在体内</em&gt;的Cerebrovasculature影像：相关性疾病CNS

Remodeling of the brain vasculature is a common trait of brain pathologies. In vivo imaging techniques are fundamental to detect cerebrovascular ...

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice

伤口的牙髓评价一个直接盖髓模型的开发和治疗小鼠中修复性牙本质形成

Dental pulp is a vital organ of a tooth fully protected by enamel and dentin. When the pulp is exposed due to cariogenic or iatrogenic injuries, it is ...

Using Retinal Imaging to Study Dementia

利用视网膜成像研究痴呆

The retina offers a unique &#8220;window&#8221; to study pathophysiological processes of dementia in the brain, as it is an extension of the central ...

Measuring the Carotid to Femoral Pulse Wave Velocity (Cf-PWV) to Evaluate Arterial Stiffness

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness

测量颈动脉股脉搏波速度 (Cf PWV) 评价动脉僵硬度

For the elderly, arterial stiffening is a good marker for aging evaluation and it is recommended that the arterial stiffness be determined noninvasively ...