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DOI :
10.3791/50984-v
•
9:06 min
January 2nd, 2014
Chapters
0:05
Title
1:52
Synthesis of Lipid-stabilized Micro and Nanoparticles
3:21
Determination of Particle Size
4:03
Preparation of Mice for i.LN. Injection
5:31
i.LN. Injection of Particles
6:33
Results: Particle Synthesis, Animal Preparation, and Lymph Node Injection
7:19
Results: Tracer Dye Drainage
7:38
Results: Visualization of Particles in Injection Lymph Nodes
8:03
Conclusion
リンパ節は免疫応答を調整する免疫組織であり、ワクチンの重要な標的です。バイオマテリアルは、より良いリンパ節を標的とし、抗原またはアジュバントの送達を制御するために採用されてきた。本論文では、これらのアイデアを組み合わせて、生体適合性ポリマー粒子をリンパ節に注入する技術について述べる。
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