Name: quantitative assessment of cortical auditory-tactile processing in children with disabilities
Uploaded: 2014-01-29T08:45:00
Description: Watch this Scientific Journal Video about Quantitative Assessment of Cortical Auditory-tactile Processing in Children with Disabilities at JoVE.com

说明该项目是由国家研究资源中心，格兰特UL1 RR024975-01支持，并正处于国家中心推进转化科学，格兰特2 UL1 TR000445-06。内容完全是作者的责任，并不一定代表美国国立卫生研究院的官方意见。

1。光响应触摸的评估<ol><li>将电极网（ 如 128通道测传感器网络）的儿童或婴儿的头部。调整传感器用温盐水充分接触。如果一个孩子，确保孩子坐在舒服的父母或照顾者的腿上。如果一个婴儿，确保婴儿轻轻包扎，要么保姆的怀里或在一个开放的婴儿床仰卧位置上。 </li><li>定位0.5厘米食指测试手的前端下方1mm的喷嘴。将手指一个年轻的孩子或手掌的婴儿在模具支架和魔术贴胶带近端和?...

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这种新颖的空气粉扑和ERP（简称“河豚系统”）来衡量的轻触觉和触觉，听觉反应的皮质处理的组合深受年轻残疾儿童和婴儿耐受。这对于unisensory和多感官的版本是正确的，而注意力组件是否加入或不幼童的情况下。的原因，这种方法在评估一个年轻而脆弱的人口的成功是由于两者使用无害的触觉刺激，以及在运用ERP的方法和设备。触觉示例，可以在总共5分钟来进行，而多感官范式需要10分钟。...

开发皮质感觉过程的研究对于了解最基础的高阶函数。感官体验是负责大部分通过婴儿期和儿童期大脑的组织，奠定了复杂的过程，如认知，沟通，和运动发育1-3的基础。大多数小儿感觉过程的研究集中在听觉和视觉领域，主要是因为这些刺激最容易发展，规范和测试。然而，触觉处理是在婴儿和儿童特别感兴趣，因为它是第一个意义上的胎儿4,5，发展，和体感信息是不可或缺的其它皮质系统功能（ 如电机，记忆，联想学习，边缘） 6。目前的方法评估体感处理是由触觉刺激的选择有限。一个常见的选择是直接电正中神经刺激7,8 </sup&gt;，对不适的可能性。其他有效的方法使用的活动任务，如识别，确认和刺激的本地化，同时需要关注和高水平的理解9。因此，所有这些方法都局限在自己的幼童及婴儿使用。 因此，我们的目标是开发触觉的范例，由是无创，减少了对主体积极参与解决这些限制。此外，它需要有刺激的标准化水平和假的控制。为此，我们制定了“河豚”系统，双通道，定时和校准的空气粉扑输送系统，使我们能够衡量的光触摸婴幼儿和其他弱势群体的影响。 功能性磁共振成像研究表明，刺激通过空气抽吸激活感觉皮层，虽然这样的研究，如固定化，楞的长度和挑战你的会话，并引起焦虑的设置，使它们难以在幼儿执行。因此，我们以提供光触摸感觉处理的时间分辨率在一份简短的，适合儿童的测试环节结合我们的新型给药系统的事件相关电位（ERP）的方法。 这一新的模式提供了必要的灵活性来研究感觉处理在不同人群，不同年龄和临床设置。它也有被用听觉刺激兼容的优势，允许多感官评估。到现在为止，准确，可靠的触觉评估一直未能在婴儿或儿童谁是无法可靠地因智力/语言障碍作出反应。这种方法旨在填补这一空白，以便在一段极大大脑的可塑性在早期识别感觉处理赤字和干预提供帮助。改善感觉处理在婴儿期可能会影响级联神经发育的 下面的程序都包含在范德比尔特机构审查委员会批准的协议。

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			<td height="22" style="height:22px;width:249px;">Geodesic sensor net</td>
			<td style="width:168px;">EGI, Inc., Eugene, OR</td>
			<td style="width:119px;">depends on size</td>
			<td style="width:167px;"></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:249px;">Net Station EEG software v. 4.2</td>
			<td style="width:168px;">EGI, Inc., Eugene, OR</td>
			<td style="width:119px;">NA</td>
			<td style="width:167px;"></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:249px;">E-Prime stimulus control application</td>
			<td style="width:168px;">PST, Inc. Pittsburgh, PA</td>
			<td style="width:119px;">NA</td>
			<td style="width:167px;"></td>
		</tr>
		<tr height="42">
			<td height="42" style="height:42px;width:249px;">Manometer (model 6&#8221; 0-60PSI)</td>
			<td style="width:168px;">H. O. Trerice Co, Oak Park, MI</td>
			<td style="width:119px;"></td>
			<td style="width:167px;"></td>
		</tr>
		<tr height="22">
			<td height="22" style="height:22px;width:249px;">Custom Puffer setup</td>
			<td style="width:168px;">Nathalie Maitre</td>
			<td style="width:119px;"></td>
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quantitative assessment of cortical auditory-tactile processing in children with disabilities

感觉处理的目的简单的测量是在非语言或脆弱的儿童患者极为困难。我们开发了一种新的方法来定量评估的轻轻一碰，讲话声音和2刺激的多感官处理孩子的皮层处理，而不需要积极的主体参与或导致儿童不适。要做到这一点，我们开发了一个双通道，时间和强度校准吹气刺激，使双方的触觉刺激和假手术对照组。我们结合这与使用事件相关电位的方法来允许信号从初级和次级躯体感觉皮质高时间分辨率以及更高的订单处理。这种方法还使我们能够测量到听觉，触觉刺激一个多感官的反应。

轻触摸（图3）评估： 到触觉刺激使用鲀系统皮层响应的特征：峰的图案响应于粉扑非常类似于使用正中神经刺激正常成人10,11得到的皮质反应。 早期反应（P50，N70，P100峰），主要反映在初级感觉皮层12的活动，并且不需要刺激的认识。 二级响应（N140峰值）主要反映在次级感觉皮层和体感刺激的认知活动作...

Watch this Scientific Journal Video about Quantitative Assessment of Cortical Auditory-tactile Processing in Children with Disabilities at JoVE.com

Quantitative Assessment of Cortical Auditory-tactile Processing in Children with Disabilities

皮质听觉，触觉加工的残疾儿童定量评价

感觉处理的目的简单的测量是在非语言或脆弱的儿童患者极为困难。我们开发了一种新的方法来定量评估婴幼儿和轻触摸孩子的皮质处理，语音声音，和2刺激的多感官处理，而不需要积极的主体参与或引起不适在脆弱的病人。

Objective and easy measurement of sensory processing is extremely difficult in nonverbal or vulnerable pediatric patients. We developed a new methodology ...

Research

JoVE Journal

Behavior

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

评估和高危新生儿的评价：新生儿重症监护病房的网络神经行为量表

There has been a long-standing interest in the assessment of the neurobehavioral integrity of the newborn infant.  The NICU Network Neurobehavioral Scale ...

科研

行为学

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia

的额边缘活度测量在儿童使用情绪穿着或行为古怪的任务与家族性高风险的精神分裂症

Adolescence is a critical developmental period where the early symptoms of schizophrenia frequently emerge. First-degree relatives of people with ...

Cortical Source Analysis of High-Density EEG Recordings in Children

高密度的脑电图记录在儿童的皮质来源分析

EEG is traditionally described as a neuroimaging technique with high temporal and low spatial resolution. Recent advances in biophysical modelling and ...

Experimental Assessment of Mouse Sociability Using an Automated Image Processing Approach

使用自动图像处理方法鼠标社交性的实验评估

Mouse is the preferred model organism for testing drugs designed to increase sociability. We present a method to quantify mouse sociability in which the ...

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder

测试儿童的感官和多感官功能自闭症谱系障碍

In addition to impairments in social communication and the presence of restricted interests and repetitive behaviors, deficits in sensory processing are ...

A Method to Quantify Visual Information Processing in Children Using Eye Tracking

一种方法来量化视觉信息加工儿童使用眼动追踪

Visual problems that occur early in life can have major impact on a child's development. Without verbal communication and only based on observational ...

Behavioral Assessment of Hearing in 2 to 4 Year-old Children: A Two-interval, Observer-based Procedure Using Conditioned Play-based Responses

2听证会，以4岁儿童的行为评估：两区间，观测为基础的应用程序基于条件性播放响应

Collecting reliable behavioral data from toddlers and preschoolers is challenging. As a result, there are significant gaps in our understanding of human ...

Assessing Working Memory in Children: The Comprehensive Assessment Battery for Children &#8211; Working Memory (CABC-WM)

Assessing Working Memory in Children: The Comprehensive Assessment Battery for Children ÃƒÆ’Ã‚Â¢ÃƒÂ¢Ã¢â‚¬Å¡Ã‚Â¬ÃƒÂ¢Ã¢â€šÂ¬Ã…â€œ Working Memory CABC-WM

评估儿童工作记忆：儿童综合评估电池 - 工作记忆（CABC-WM）

The Comprehensive Assessment Battery for Children - Working Memory (CABC-WM) is a computer-based battery designed to assess different components of ...

Multi-layer Cortical Ca2+ Imaging in Freely Moving Mice with Prism Probes and Miniaturized Fluorescence Microscopy

Multi-layer Cortical Ca2+ Imaging in Freely Moving Mice with Prism Probes and Miniaturized Fluorescence Microscopy

多层皮质Ca<sup&gt; 2+</sup&gt;使用棱镜探针和小型荧光显微镜成像自由移动的小鼠

In vivo circuit and cellular level functional imaging is a critical tool for understanding the brain in action. High resolution imaging of mouse cortical ...

An Electrophysiology Protocol to Measure Reward Anticipation and Processing in Children

儿童奖励预期与处理的电生理学协议

We present a protocol designed to measure the neural correlates of reward in children. The protocol allows researchers to measure both reward anticipation ...