Name: quantitative assessment of cortical auditory-tactile processing in children with disabilities
Uploaded: 2014-01-29T08:45:00
Description: Watch this Scientific Journal Video about Quantitative Assessment of Cortical Auditory-tactile Processing in Children with Disabilities at JoVE.com

Det beskrevne projekt blev støttet af National Center for Research Resources, Grant UL1 RR024975-01, og er nu på National Center for Fremme Translationelle Sciences, Grant 2 UL1 TR000445-06. Indholdet er alene forfatternes ansvar og repræsenterer ikke nødvendigvis de officielle synspunkter NIH.

1.. Vurdering af Reaktion på Light Touch <ol><li> Anbring elektroden net (f.eks 128-kanaler geodætiske sensor netto) på barnet eller barnets hoved. Juster sensorer til fuld kontakt med varmt saltvand. Hvis der på et barn, sikre barnet sidder komfortabelt i forælder eller pårørende skød. Hvis der på et spædbarn, sørge for, at barnet er let svøbt og enten holdt i omsorgsperson arme eller i liggende stilling i en åben vugge. </li><li> Placer en 1 mm dyse 0,5 cm under spidsen af ​​pegefingeren af...

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Denne roman kombination af luft pust og ERP (benævnt &quot;Puffer-systemet&quot;), til at måle cortical behandling af let berøring og taktile-auditive reaktioner tåles godt af børn med handicap, og spædbørn. Dette gælder for unisensory og multisensoriske versioner, og om der er tilsat opmærksomhedskravet komponent eller ikke i tilfælde af små børn. Årsagerne til succesen af ​​denne metode til at vurdere en ung og sårbar befolkning skyldes både anvendelsen af ​​et uskadeligt taktil stimuli samt bru...

Studiet af udviklingen kortikale sensoriske processer er afgørende for at forstå grundlaget for de fleste højere orden funktioner. Sanseoplevelser er ansvarlig for meget af hjernens organisation gennem barndom og opvækst, om grundlaget for komplekse processer såsom kognition, kommunikation og motoriske udvikling 1-3. De fleste pædiatriske undersøgelser af sensoriske processer fokuserer på auditive og visuelle domæner, især fordi disse stimuli er lettest at udvikle, standardisere og test. Men taktil behandlingen er af særlig interesse hos spædbørn og børn, da det er den første mening at udvikle i fosteret 4,5, og somatosensoriske information er en integreret del af funktionen af andre kortikale systemer (fx motor, hukommelse, associativ læring, limbiske) 6.. Nuværende metoder til vurdering somatosensoriske behandling er begrænset af valget af taktile stimuli. En fælles valg er direkte elektrisk median nerve stimulation 7,8 </sup&gt;, Med mulighed for ubehag. Andre effektive metoder bruger aktive opgaver såsom diskrimination, anerkendelse, og lokalisering af stimuli, der kræver både opmærksomhed og høje niveauer af forståelse 9. Alle disse fremgangsmåder er derfor begrænset i deres anvendelse i små børn og spædbørn. Derfor er vores mål var at udvikle en taktil paradigme, der omhandler disse begrænsninger ved at være noninvasive og reducere behovet for et emne aktive deltagelse. Derudover var det nødvendigt at have en harmoniseret stimulation og humbug-kontrol. Til dette har vi udviklet det &quot;puffer&quot;-system, en dual-channel, timet, og kalibreret air-puff delivery system, der giver os mulighed for at måle effekten af ​​let berøring hos spædbørn og andre sårbare befolkningsgrupper. Funktionel MRI undersøgelser viste, at stimulation af pust af luft aktiverer sensoriske cortex, selvom længden og udfordringer af sådanne undersøgelser, såsom immobilisering lengdine sessions og indstillinger angstprovokerende gør dem svære at udføre i småbørn. Derfor har vi kombineret vores roman delivery system med Event-Related Potential (ERP) metode for at give tidsmæssige opløsning af sensorisk forarbejdning af let berøring i en kort, børnevenlig test session. Dette nye paradigme giver den nødvendige fleksibilitet til at studere sensorisk forarbejdning i forskellige befolkningsgrupper, aldre og kliniske omgivelser. Det har også den fordel, at de er kompatible med auditive stimuli, der giver mulighed for multisensoriske vurderinger. Indtil nu har nøjagtig og pålidelig taktil vurdering ikke været muligt hos spædbørn eller børn, der er i stand til pålideligt at reagere på grund af intellektuel / sprogforstyrrelser. Denne metode har til formål at udfylde dette hul, for at hjælpe med tidlig identifikation af sensoriske forarbejdning underskud og intervention i en periode med maksimal hjernens plasticitet. Forbedringer i sensorisk behandling i barndommen kan påvirke kaskadeaf neurologiske Følgende procedurer er alle inkluderet i Vanderbilt Institutional Review Board godkendte protokoller.

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			<td height="22" style="height:22px;width:249px;">Geodesic sensor net</td>
			<td style="width:168px;">EGI, Inc., Eugene, OR</td>
			<td style="width:119px;">depends on size</td>
			<td style="width:167px;"></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:249px;">Net Station EEG software v. 4.2</td>
			<td style="width:168px;">EGI, Inc., Eugene, OR</td>
			<td style="width:119px;">NA</td>
			<td style="width:167px;"></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:249px;">E-Prime stimulus control application</td>
			<td style="width:168px;">PST, Inc. Pittsburgh, PA</td>
			<td style="width:119px;">NA</td>
			<td style="width:167px;"></td>
		</tr>
		<tr height="42">
			<td height="42" style="height:42px;width:249px;">Manometer (model 6&#8221; 0-60PSI)</td>
			<td style="width:168px;">H. O. Trerice Co, Oak Park, MI</td>
			<td style="width:119px;"></td>
			<td style="width:167px;"></td>
		</tr>
		<tr height="22">
			<td height="22" style="height:22px;width:249px;">Custom Puffer setup</td>
			<td style="width:168px;">Nathalie Maitre</td>
			<td style="width:119px;"></td>
			<td style="width:167px;"></td>
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quantitative assessment of cortical auditory-tactile processing in children with disabilities

Formål og nem måling af sensorisk forarbejdning er yderst vanskeligt i nonverbale eller sårbare pædiatriske patienter. Vi har udviklet en ny metode til kvantitativt at vurdere børns kortikal behandling af let berøring, tale lyde og multisensorisk behandling af de 2 stimuli, uden at det kræver aktiv emne deltagelse eller forårsager børn ubehag. For at opnå dette har vi udviklet en dobbelt kanal, tid og kræfter kalibreret luft pust stimulator, der tillader både taktil stimulation og humbug kontrol. Vi kombinerede dette med brug af event-relaterede potentiel metode til at give mulighed for høj tidslig opløsning af signaler fra de primære og sekundære somatosensoriske cortex samt højere ordrebehandling. Denne metode også tilladt os at måle en multisensory reaktion på auditive, taktile stimulation.

Vurdering af let berøring (figur 3): Karakteristik af kortikale respons på taktil stimulation ved hjælp af Puffer system: De mønstre af toppe som svar på pudderkvast er meget lig de kortikale respons opnået ved hjælp af median nerve stimulation i normale voksne 10,11. Den tidlige respons (P50, N70, P100 toppe) afspejler primært aktivitet i den primære sensoriske cortex 12 og kræver ikke bevidsthed om stimulering. <strong...

Watch this Scientific Journal Video about Quantitative Assessment of Cortical Auditory-tactile Processing in Children with Disabilities at JoVE.com

Quantitative Assessment of Cortical Auditory-tactile Processing in Children with Disabilities

Kvantitativ vurdering af Cortical Auditory-taktile Processing i Børn med handicap

Formål og nem måling af sensorisk forarbejdning er yderst vanskeligt i nonverbale eller sårbare pædiatriske patienter. Vi har udviklet en ny metode til kvantitativ vurdering spædbørn og børns kortikal behandling af let berøring, lyde tale og multisensorisk behandling af de 2 stimuli, uden at det kræver aktiv emne deltagelse eller forårsager ubehag i sårbare patienter.

Objective and easy measurement of sensory processing is extremely difficult in nonverbal or vulnerable pediatric patients. We developed a new methodology ...

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