Name: utility of dissociated intrinsic hand muscle atrophy in the diagnosis of amyotrophic lateral sclerosis
Uploaded: 2014-03-04T14:00:00
Description: Watch this Scientific Journal Video about Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis at JoVE.com

Finansiering støtte fra Motor Neuron Disease Research Institute of Australia (MNDRIA), Sylvia og Charles Viertel Charitable Foundation Klinisk Investigator tilskud, Ramaciotti Foundation og National Health og Medical Research Council i Australien (Projektbevilling nummer APP1024915) er modtaget med tak.

1.. Forberedelse af patient <ol><li> Rekruttere patienter fremadrettet og fortløbende. Bemærk: Følgende protokol er godkendt af Sydney West Area Health Service Menneskelige Research etiske komitéer. Informeret samtykke blev leveret af alle patienter. Patienterne blev rekrutteret fremadrettet og fortløbende ALS / neuromuskulære klinik på Westmead Hospital. </li><li> Bestem egnethed ALS patienter til test. Udelukke patienter, som ikke er diagnosticeret med ALS eller en neuromuskulær lidelse. </li><li> Udeluk pat...

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J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+&#8220;split+hand+syndrome&#8220;.">The &#8220;split hand syndrome&#8220;.</a> Muscle Nerve. 23, 138 (2000).</li><li>Kuwabara, S., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Dissociated+small+hand+muscle+atrophy+in+amyotrophic+lateral+sclerosis:+frequency,+extent,+and+specificity.">Dissociated small hand muscle atrophy in amyotrophic lateral sclerosis: frequency, extent, and specificity.</a> Muscle Nerve. 37, 426-430 (2008).</li><li>Kuwabara, S., Mizobuchi, K., Ogawara, K., Hattori, T. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Dissociated+small+hand+muscle+involvement+in+amyotrophic+lateral+sclerosis+detected+by+motor+unit+number+estimates.">Dissociated small hand muscle involvement in amyotrophic lateral sclerosis detected by motor unit number estimates.</a> Muscle Nerve. 22, 870-873 (1999).</li><li>Menon, P., Kiernan, M. 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Nærværende undersøgelse rapporter om den diagnostiske anvendelighed af split hånd indekset i ALS, en roman neurofysiologisk diagnostisk biomarkør. SI pålideligt skelnes ALS fra neuromuskulære lidelser, med en optimal diagnostisk cut-off værdi på 5,2. Reduktionen i SI var mest fremtrædende i lemmer debuterede ALS-patienter. Vigtigere er det, en væsentlig del af ALS-patienter, der var klassificeret i kategorien diagnostiske &quot;muligt&quot;, som pr nyligt udviklede diagnostiske kriterier 11, udvist...

Opdelingen hånd, henviser til præferentiel atrofi af thenar kompleks gruppe af iboende håndmuskler [bortføreren pollicis brevis (APB) og første dorsale interosseous (FDI)], med relativ bevarelse af hypotenarregionen muskler, og er en specifik og tidlig klinisk funktion i amyotrofisk lateral sklerose (ALS) 1-4. Konstateringen af, at opdelingen hånd tegn er specifik for ALS, foreslår en mulig rolle for split hånd tegn som en diagnostisk biomarkør i ALS 3. Kvantificering af split hånd tegn, gennem udvikling af en ny neurofysiologisk biomarkør, kan yderligere støtte i ALS diagnose. Konkret er split hånd indeks (SI), som kvantificerer split hånd fænomen, beregnes ved at multiplicere den sammensatte muskel handling potentiale (CMAP) amplitude optaget over thenar komplekse muskler (APB og FDI), og dividere dette produkt fra CMAP amplitude registreret over hypothenar muskler (nemlig bortføreren digitalisering Minimi, ADM) 5.. Diagnosen ALS beror i vid udstrækning på klinisk baserede kriterier omfatter en kombination af øvre og nedre motor neuron underskriver 6. Disse kriterier blev imidlertid anset for ufølsom især etablere en diagnose af ALS i de tidlige stadier af sygdommen proces 7-10. En nylig ændring af de diagnostiske kriterier blev udviklet 11, og selv om disse kriterier ser ud til at øge den diagnostiske sensitivitet 12-16 stigningen følsomhed synes begrænset til bulbar debut ALS patienter 15. I mangel af en pathognomonic test, kan diagnosen ALS blive væsentligt forsinket 8. I sidste ende kan den institution neuroprotektive behandlingsformer og rekruttering til kliniske forsøg blive forsinket, måske ud over de kritiske terapeutiske vindue periode 9, 17. Følgeligdiagnostisk anvendelighed af SI blev prospektivt vurderet i sporadiske ALS-patienter.

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			<td style="width:136px;"></td>
			<td style="width:203px;"></td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;">Abrasive gel (Nu Prep)</td>
			<td>Weaver and Company</td>
			<td>N-TA\/P\H-3 ENG</td>
			<td>Skin preperation</td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;"></td>
			<td colspan="2">(www.doweaver.com)</td>
			<td></td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;"></td>
			<td></td>
			<td></td>
			<td></td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;">Alcohol wipe</td>
			<td>Triad Disposables</td>
			<td>103101</td>
			<td>Skin preperation</td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;"></td>
			<td colspan="2">(www.triad-group.net)</td>
			<td></td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;"></td>
			<td></td>
			<td></td>
			<td></td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;">Recording gel (Ten20 Conductive gel)</td>
			<td>Weaver and Company</td>
			<td>N-TA\/P\H-3 ENG</td>
			<td>Recording motor responses</td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;"></td>
			<td colspan="2">(www.doweaver.com)</td>
			<td></td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;"></td>
			<td></td>
			<td></td>
			<td></td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;">Amyotrophic lateral sclerosis rating scale-revised questionnaire</td>
			<td>Publication&#160;</td>
			<td>Experimental builder</td>
			<td>Stage disease</td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;"></td>
			<td colspan="2">(see Methods and References)</td>
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			<td></td>
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		</tr>
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			<td height="20" style="height:20px;">Medical Research Council muscle strength scale</td>
			<td>Medical Research Council-UK</td>
			<td>Experimental builder</td>
			<td>Stage disease</td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;"></td>
			<td colspan="2">(see Methods and References)</td>
			<td></td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;"></td>
			<td></td>
			<td></td>
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			<td colspan="2" height="20" style="height:20px;">Table of equipment used</td>
			<td></td>
			<td></td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;">Name of the equipment used</td>
			<td>Company</td>
			<td>Catalog number</td>
			<td>Comments</td>
		</tr>
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			<td height="20" style="height:20px;"></td>
			<td></td>
			<td></td>
			<td></td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;">Nerve conduction machine (Synergy/Nicolet EDX)</td>
			<td>CareFusion (www.carefusion.com/medical-products/neurology)</td>
			<td>SA110106M</td>
			<td>To measure split hand index</td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;"></td>
			<td></td>
			<td></td>
			<td></td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;">Synergy software</td>
			<td>CareFusion</td>
			<td>765654679</td>
			<td>To measure split hand index</td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;"></td>
			<td colspan="3">(www.carefusion.com/medical-products/neurology)</td>
		</tr>
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			<td height="20" style="height:20px;"></td>
			<td></td>
			<td></td>
			<td></td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;">Tem millimeter gold cup disc electrodes</td>
			<td>Grass Technologies</td>
			<td>F-E5GH-60</td>
			<td>To record motor responses</td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;"></td>
			<td colspan="2">(www.grasstechnologies.com)</td>
			<td></td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;"></td>
			<td></td>
			<td></td>
			<td></td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;">Neural earth plate</td>
			<td>Westmead Hospital</td>
			<td>Experimental builder</td>
			<td>To record limb temperature</td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;"></td>
			<td></td>
			<td></td>
			<td></td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;">Thermometer</td>
			<td>Westmead Hospital</td>
			<td>Experimental builder</td>
			<td>To record limb temperature</td>
		</tr>
	</tbody>
</table>

utility of dissociated intrinsic hand muscle atrophy in the diagnosis of amyotrophic lateral sclerosis

Opdelingen hånd fænomen refererer til fremherskende spild af thenar musklerne og er et tidligt og særligt træk ved amyotrofisk lateral sklerose (ALS). En roman split hånd indeks (SI) blev udviklet for at kvantificere split hånd fænomen, og dens diagnostiske hjælpeprogram blev vurderet i ALS-patienter. Opdelingen hånd-indekset blev afledt ved at dividere resultatet af den sammensatte muskel handling potentiale (CMAP) amplitude optaget over bortføreren pollicis brevis og første dorsale interosseous muskler ved CMAP amplitude registreret over bortføreren digitalisering minimi muskel. For at vurdere den diagnostiske anvendelighed af split hånd indekset blev ALS patienter prospektivt vurderes og deres resultater blev sammenlignet med neuromuskulære lidelse patienter. Opdelingen hånd indeks blev signifikant reduceret i ALS sammenlignet med neuromuskulære sygdom patienter (P &lt;0,0001). Limb debuterende ALS-patienter udviste den største reduktion i split hånd indeks, og en værdi5,2 eller mindre pålideligt opdelte ALS fra andre neuromuskulære lidelser. Derfor synes split hånd indekset at være en roman diagnostisk biomarkør for ALS, måske lette en tidligere diagnosticering.

Klinisk Fænotype I alt blev 44 ALS-patienter undersøgte, hvoraf 76% (N = 33) blev klassificeret som sikker eller sandsynlig og 24% (N = 11) som mulige ALS ifølge Awaji kriterier 11.. Diagnosen ALS blev bekræftet i &quot;mulige&quot; kohorte efter omfattende undersøgelser og klinisk opfølgning i op til 3 år og 53% døde i denne periode. Bulbær debuterende sygdom var tydelig i 41%, mens lemmer debut i 59% af ALS-patienter. På tidspunktet for vurderingen, gennemsnitli...

Watch this Scientific Journal Video about Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis at JoVE.com

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis

Utility af dissocierede Intrinsic Hand muskelatrofi i diagnosen af ​​Amyotrofisk Lateral Sclerose

Dissocierede atrofi af iboende hånd muskler, kaldet split hånd, synes at være et særligt træk ved amyotrofisk lateral sklerose (ALS). Derfor er en ny neurodiagnostic test, betegnes delt hånd indeks, blev udviklet til at kvantificere den kliniske fænomen split hånd, som opdelte ALS fra mimiske lidelser.

The split hand phenomenon refers to predominant wasting of thenar muscles and is an early and specific feature of amyotrophic lateral sclerosis (ALS). A ...

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The tibial nerve transection model is a well-tolerated, validated, and reproducible model of denervation-induced skeletal muscle atrophy in rodents. ...

High-throughput Flow Cytometry Cell-based Assay to Detect Antibodies to N-Methyl-D-aspartate Receptor or Dopamine-2 Receptor in Human Serum

High-throughput Flowcytometri cellebaseret assay til påvisning af antistoffer til N-methyl-D-aspartat-receptor eller dopamin-2-receptoren i humant serum

Over the recent years, antibodies against surface and conformational proteins involved in neurotransmission have been detected in autoimmune CNS diseases ...

Ischemic Tissue Injury in the Dorsal Skinfold Chamber of the Mouse: A Skin Flap Model to Investigate Acute Persistent Ischemia

Iskæmisk væv skade i Dorsal hudfolden Afdeling Mus: En hudlap modellen til Akut Persistent Iskæmi

Despite profound expertise and advanced surgical techniques, ischemia-induced complications ranging from wound breakdown to extensive tissue necrosis are ...

Single-stage Dynamic Reanimation of the Smile in Irreversible Facial Paralysis by Free Functional Muscle Transfer

Et-trins Dynamic Reanimation af Smile i Irreversible Facial Lammelse af Free Funktionel Muscle Transfer

Unilateral facial paralysis is a common disease that is associated with significant functional, aesthetic and psychological issues. Though idiopathic ...

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

En metode til Trigonometriske Modellering årstidsvariationernes demonstreret med multipel sklerose Relapse data

This report describes a novel Stata-based application of trigonometric regression modelling to  55 years of multiple sclerosis relapse data from 46 ...

Design, Fabrication, and Administration of the Hand Active Sensation Test (HASTe)

Design, Fabrication, and Administration of the Hand Active Sensation Test HASTe

Design, fremstilling, og Administration af hånden Active Sensation Test (Haste)

The concept of personalizing neurologic rehabilitation, based on individual impairments, has experienced a recent surge. In parallel, the number of ...

Utility af dissocierede Intrinsic Hand muskelatrofi i diagnosen af ​​Amyotrofisk Lateral Sclerose

Utility af dissocierede Intrinsic Hand muskelatrofi i diagnosen af Amyotrofisk Lateral Sclerose