Name: utility of dissociated intrinsic hand muscle atrophy in the diagnosis of amyotrophic lateral sclerosis
Uploaded: 2014-03-04T14:00:00
Description: Watch this Scientific Journal Video about Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis at JoVE.com

Motor Nöron Hastalığı Araştırma Avustralya Enstitüsü (MNDRIA), Sylvia ve Charles Viertel Vakfı Klinik Araştırmacı hibe, Ramaciotti Vakfı ve Ulusal Sağlık ve Avustralya Tıp Araştırma Konseyi (Proje hibe sayısı APP1024915) destek fon minnetle kabul edilmektedir.

1.. Hasta Hazırlama <ol><li> Prospektif ve ardışık hasta işe. Not: Aşağıdaki protokol Sydney Batı Bölgesi Sağlık Servisi İnsan Araştırmaları Etik Kurulları tarafından onaylanmıştır. Aydınlatılmış onam, tüm hastalar tarafından verildi. Hastalar Westmead Hastanesi&#39;nde ALS / nöromüsküler kliniği prospektif ve ardışık alındı. </li><li> Test için ALS hastalarının uygunluğunu belirler. ALS ya da bir nöromüsküler bozukluğu tanısı olmayan hastaların dışlanması. </li><li> B...

<ol>
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J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+&#8220;split+hand+syndrome&#8220;.">The &#8220;split hand syndrome&#8220;.</a> Muscle Nerve. 23, 138 (2000).</li><li>Kuwabara, S., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Dissociated+small+hand+muscle+atrophy+in+amyotrophic+lateral+sclerosis:+frequency,+extent,+and+specificity.">Dissociated small hand muscle atrophy in amyotrophic lateral sclerosis: frequency, extent, and specificity.</a> Muscle Nerve. 37, 426-430 (2008).</li><li>Kuwabara, S., Mizobuchi, K., Ogawara, K., Hattori, T. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Dissociated+small+hand+muscle+involvement+in+amyotrophic+lateral+sclerosis+detected+by+motor+unit+number+estimates.">Dissociated small hand muscle involvement in amyotrophic lateral sclerosis detected by motor unit number estimates.</a> Muscle Nerve. 22, 870-873 (1999).</li><li>Menon, P., Kiernan, M. 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Bu çalışma ALS, yeni nörofizyolojik tanı biyomarkeri içinde bölünmüş el indeksi tanısal yarar bildiriyor. SI güvenilir 5.2 optimal tanı cut-off değeri ile, nöromüsküler bozukluklar ALS ayırt. SI azalma uzuv başlangıçlı ALS hastalarında en belirgin oldu. Önemlisi, yeni geliştirilen tanı kriterleri 11 başı olarak tanı &quot;olası&quot; kategorisinde sınıflandırıldı ALS hastalarının önemli bir kısmı, anormal SI sergiledi. Birlikte ele alındığında, bu çalışmada elde ...

Bölünmüş el, hipotenar kasların göreceli korunarak, iç el kaslarının tenar karmaşık bir grup [Abduktor pollisis brevis (APB) ve birinci dorsal interosseous (DYY)] tercihli atrofi anlamına gelir ve Amiotropik belirli ve erken klinik özelliktir lateral skleroz (ALS) 1-4. Bölünmüş el işareti ALS için özel olduğunu bulgu, ALS 3 tanısal bir belirteç olarak bölünmüş el işareti için potansiyel bir rol oynadığını düşündürmektedir. Bölünmüş el işaretinin Kantitasyonu, yeni bir biyolojik belirteç nörofizyolojik geliştirilmesi yoluyla, ALS tanısı yardım daha fazla olabilir. Özellikle, bölünmüş el fenomeni rakamlarla ayrılmış el indeksi (SI), bileşik kas aksiyon potansiyeli (CMAP) çarpılmasıyla elde edilir tenar kompleks kaslar (APB ve DYY) üzerinde kaydedilen ve CMAP Bu ürünü bölünmesi genlik HYP üzerinde kaydedilenothenar kaslar (yani kaçıran digiti minimide, ADM) 5. ALS tanısı 6 imzalar üst ve alt motor nöron bir arada kapsayan klinik tabanlı kriterlerine büyük ölçüde dayanır. Bu kriterler, ancak, özellikle de hastalık süreci 7-10 erken dönemlerinde ALS bir tanı konulmuş duyarsız kabul edildi. Tanı kriterlerinin bir yeni değişiklik 11 gelişmiş ve bu kriterler tanı duyarlılığını artırmak 12-16 görünmesine rağmen, artış hassasiyet bulber başlangıçlı ALS hastalarında 15 ile sınırlı görünüyor edildi. Patognomonik testi yokluğunda, ALS tanı önemli 8 gecikebilir. Sonuçta, klinik içine nöroprotektif tedaviler ve işe alım kurumu belki de kritik tedavi pencere dönemi 9, 17 ötesinde, gecikebilir. Sonuç olarak,SI tanılama yardımcı prospektif sporadik ALS hastalarında değerlendirildi.

<table border="0" cellpadding="0" cellspacing="0">
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			<td height="20" style="height:20px;width:125px;"></td>
			<td style="width:120px;"></td>
			<td style="width:136px;"></td>
			<td style="width:203px;"></td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;">Abrasive gel (Nu Prep)</td>
			<td>Weaver and Company</td>
			<td>N-TA\/P\H-3 ENG</td>
			<td>Skin preperation</td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;"></td>
			<td colspan="2">(www.doweaver.com)</td>
			<td></td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;"></td>
			<td></td>
			<td></td>
			<td></td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;">Alcohol wipe</td>
			<td>Triad Disposables</td>
			<td>103101</td>
			<td>Skin preperation</td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;"></td>
			<td colspan="2">(www.triad-group.net)</td>
			<td></td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;"></td>
			<td></td>
			<td></td>
			<td></td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;">Recording gel (Ten20 Conductive gel)</td>
			<td>Weaver and Company</td>
			<td>N-TA\/P\H-3 ENG</td>
			<td>Recording motor responses</td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;"></td>
			<td colspan="2">(www.doweaver.com)</td>
			<td></td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;"></td>
			<td></td>
			<td></td>
			<td></td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;">Amyotrophic lateral sclerosis rating scale-revised questionnaire</td>
			<td>Publication&#160;</td>
			<td>Experimental builder</td>
			<td>Stage disease</td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;"></td>
			<td colspan="2">(see Methods and References)</td>
			<td></td>
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			<td></td>
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		</tr>
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			<td height="20" style="height:20px;">Medical Research Council muscle strength scale</td>
			<td>Medical Research Council-UK</td>
			<td>Experimental builder</td>
			<td>Stage disease</td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;"></td>
			<td colspan="2">(see Methods and References)</td>
			<td></td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;"></td>
			<td></td>
			<td></td>
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			<td colspan="2" height="20" style="height:20px;">Table of equipment used</td>
			<td></td>
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		<tr height="20">
			<td height="20" style="height:20px;">Name of the equipment used</td>
			<td>Company</td>
			<td>Catalog number</td>
			<td>Comments</td>
		</tr>
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			<td></td>
			<td></td>
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		</tr>
		<tr height="20">
			<td height="20" style="height:20px;">Nerve conduction machine (Synergy/Nicolet EDX)</td>
			<td>CareFusion (www.carefusion.com/medical-products/neurology)</td>
			<td>SA110106M</td>
			<td>To measure split hand index</td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;"></td>
			<td></td>
			<td></td>
			<td></td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;">Synergy software</td>
			<td>CareFusion</td>
			<td>765654679</td>
			<td>To measure split hand index</td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;"></td>
			<td colspan="3">(www.carefusion.com/medical-products/neurology)</td>
		</tr>
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			<td height="20" style="height:20px;"></td>
			<td></td>
			<td></td>
			<td></td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;">Tem millimeter gold cup disc electrodes</td>
			<td>Grass Technologies</td>
			<td>F-E5GH-60</td>
			<td>To record motor responses</td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;"></td>
			<td colspan="2">(www.grasstechnologies.com)</td>
			<td></td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;"></td>
			<td></td>
			<td></td>
			<td></td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;">Neural earth plate</td>
			<td>Westmead Hospital</td>
			<td>Experimental builder</td>
			<td>To record limb temperature</td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;"></td>
			<td></td>
			<td></td>
			<td></td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;">Thermometer</td>
			<td>Westmead Hospital</td>
			<td>Experimental builder</td>
			<td>To record limb temperature</td>
		</tr>
	</tbody>
</table>

utility of dissociated intrinsic hand muscle atrophy in the diagnosis of amyotrophic lateral sclerosis

Bölünmüş El olgu tenar kasların baskın israf anlamına gelir ve amiyotrofik lateral skleroz (ALS) erken ve özel bir özelliktir. Bir roman bölünmüş el indeksi (SI) bölünmüş el fenomeni ölçmek için geliştirilen, ve tanısal yarar ALS hastalarında değerlendirildi. Bölünmüş el indeksi bileşik kas aksiyon potansiyeli (CMAP) ürünü bölünmesi ile elde edilmiştir Abduktor digiti minimide kası üzerinde kaydedilen CMAP tarafından Abduktor pollisis brevis ve birinci dorsal interosseous kaslar üzerinde kaydedilen genlik. Bölünmüş el indeksi tanılama programını değerlendirmek amacıyla, ALS hasta prospektif olarak değerlendirildi ve sonuçları nöromüsküler bozukluğu hastalarında karşılaştırılmıştır. Nöromüsküler bozukluğu olan hastaların (p &lt;0.0001) göre ayrılmış el indeksi anlamlı ALS azaltıldı. Ekstremite-başlangıçlı ALS hastalar bölünmüş el endeksinde en büyük düşüş, ve bir değer sergiledidiğer nöromüsküler bozukluklar 5.2 ya da daha az güvenilir bir farklılaşmış ALS. Sonuç olarak, bölme el indeksi, belki de daha önceki bir tanı kolaylaştırmak, ALS için yeni bir tanısal biyolojik olarak görünmektedir.

Klinik Fenotip Toplamda, 44 hastada ALS% 76 (N = 33) mümkün ALS olarak kesin ya da muhtemel ve% 24 (N = 11) olarak sınıflandırıldı Awaji kriterlere 11 göre, bunlardan incelenmiştir. Kapsamlı araştırmalar ve 3 yıla kadar ve% 53 klinik takip, bu dönemde öldükten sonra ALS teşhisi &quot;olası&quot; grubunda teyit edildi. Bulber başlangıçlı hastalık% 41 belli oldu, ise ALS hastalarının% 59 ekstremite başlangıçlı. Değerlendirme zamanda, hastalık s?...

Watch this Scientific Journal Video about Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis at JoVE.com

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis

Amyotrofik Lateral Skleroz Tanısında Disosiye ıntrinsic El kas Atrofi Utility

Iç el kaslannda aynştınlmış atrofisi, bölünmüş el olarak adlandırılan, amyotrofik lateral skleroz (ALS), belirli bir özellik olarak görülmektedir. Sonuç olarak, bir roman Neurodiagnostic testi, mimik bozukluğu ALS ayırt bölünmüş elin klinik fenomen, ölçmek için geliştirilen, bölünmüş el endeksi olarak adlandırılır.

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Improved methods for assessing bulbar impairment are necessary for expediting diagnosis of bulbar dysfunction in ALS, for predicting disease progression ...

Intraspinal Cell Transplantation for Targeting Cervical Ventral Horn in Amyotrophic Lateral Sclerosis and Traumatic Spinal Cord Injury

Amyotrophic Lateral Sclerosis ve Travmatik Spinal Kord Yaralanması Servikal Ventral Horn Hedefleme intraspinal Hücre Transplantasyonu

Respiratory compromise due to phrenic motor neuron loss is a debilitating consequence of a large proportion of human traumatic spinal cord injury (SCI) ...

Clinical Testing and Spinal Cord Removal in a Mouse Model for Amyotrophic Lateral Sclerosis (ALS)

Clinical Testing and Spinal Cord Removal in a Mouse Model for Amyotrophic Lateral Sclerosis ALS

Amyotrofik Lateral Skleroz için Fare Modeli (ALS) Klinik Test ve Omurilik Kaldırma

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder resulting in progressive degeneration of motoneurons. Peak of onset is around 60 ...

Real-time Digital Imaging of Leukocyte-endothelial Interaction in Ischemia-reperfusion Injury (IRI) of the Rat Cremaster Muscle

Real-time Digital Imaging of Leukocyte-endothelial Interaction in Ischemia-reperfusion Injury IRI of the Rat Cremaster Muscle

Sıçan Cremaster&#39;ın kas iskemi-reperfüzyon Hasarı içinde Lökosit-endotelyal Etkileşim Gerçek zamanlı Dijital Görüntüleme (IRI)

Ischemia-reperfusion injury (IRI) has been implicated in a large array of pathological conditions such as cerebral stroke, myocardial infarction, ...

Tibial Nerve Transection - A Standardized Model for Denervation-induced Skeletal Muscle Atrophy in Mice

Tibial Sinir transeksiyonu - Farelerde denervasyon bağlı İskelet Kas Atrofi için bir Standart Model

The tibial nerve transection model is a well-tolerated, validated, and reproducible model of denervation-induced skeletal muscle atrophy in rodents. ...

High-throughput Flow Cytometry Cell-based Assay to Detect Antibodies to N-Methyl-D-aspartate Receptor or Dopamine-2 Receptor in Human Serum

İnsan Serum içinde N-metil-D-aspartat reseptör ya da dopamin-2 reseptör antikorları algılamak üzere yüksek verimli Flow Cytometry hücre bazlı bir deneyde

Over the recent years, antibodies against surface and conformational proteins involved in neurotransmission have been detected in autoimmune CNS diseases ...

Ischemic Tissue Injury in the Dorsal Skinfold Chamber of the Mouse: A Skin Flap Model to Investigate Acute Persistent Ischemia

Mouse Dorsal Skinfold Odası&#39;nda İskemik Doku Yaralanması: Bir Cilt Flap Model Akut Kalıcı iskemisi Araştırma

Despite profound expertise and advanced surgical techniques, ischemia-induced complications ranging from wound breakdown to extensive tissue necrosis are ...

Single-stage Dynamic Reanimation of the Smile in Irreversible Facial Paralysis by Free Functional Muscle Transfer

Ücretsiz Fonksiyonel kas transferi ile geri dönüşümsüz Yüz felci içinde Smile Tek aşamalı Dinamik Reanimasyon

Unilateral facial paralysis is a common disease that is associated with significant functional, aesthetic and psychological issues. Though idiopathic ...

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Multipl Skleroz Relaps Verilerle kanıtlanmış Mevsimsel Değişim Trigonometrik Modelleme Bir Yöntem

This report describes a novel Stata-based application of trigonometric regression modelling to  55 years of multiple sclerosis relapse data from 46 ...

Design, Fabrication, and Administration of the Hand Active Sensation Test (HASTe)

Design, Fabrication, and Administration of the Hand Active Sensation Test HASTe

Tasarım, ve Yönetim El Fabrikasyon Aktif Sensation Testi (Haste)

The concept of personalizing neurologic rehabilitation, based on individual impairments, has experienced a recent surge. In parallel, the number of ...