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An Introduction to the Laboratory Mouse: Mus musculus

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Mice (Mus musculus) are an important research tool for modeling human disease progression and development in the lab. Despite differences in their size and appearance, mice share a distinct genetic similarity to humans, and their ability to reproduce and mature quickly make them efficient and economical candidate mammals for scientific study.

This video provides a brief overview of mice, both as organisms and in terms of their many advantages as experimental models. The discussion features an introduction to common laboratory mouse strains, including the nude mouse, whose genetic makeup renders them both hairless and immunodeficient. A brief history of mouse research is also offered, ranging from their first use in genetics experiments to Nobel prize-winning discoveries in immunology and neurobiology. Finally, representative examples of the diverse types of research that can be performed in mice are presented, such as classic behavioral tests like the Morris water maze and in-depth investigations of mammalian embryonic development.

Procedura

Rodents make up about 90% of all the animals used in research, the majority of which are mice.

Mice are easy and inexpensive to maintain, and their genetic similarity to humans, coupled with their short generation time and high fertility, make them ideal candidates for genetic manipulation and study.

This video provides an overview of the mouse as a model organism and discusses some of its many applications in biological and biomedical research.

The common house mouse, M

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Tags

Laboratory MouseMus MusculusResearch AnimalsGenetic ManipulationModel OrganismBiological ResearchBiomedical ResearchCommon House MouseRodentiaMammalian ClassVertebratesSmall MammalsLife CycleGestation PeriodSexually Mature AdultsAdaptabilityCommensal Species

Vai a...

0:00

Overview

0:43

The Common House Mouse: An Overview

1:59

Advantages to Using the Mouse as a Model System

4:07

Key Discoveries Made in Mice

7:00

Applications

8:40

Summary

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