Name: eeg mu rhythm in typical and atypical development
Uploaded: 2014-04-09T22:15:00
Description: Watch this Scientific Journal Video about EEG Mu Rhythm in Typical and Atypical Development at JoVE.com

这项工作是由西蒙斯基金会（SFARI＃89638到RB）的资助。

以下协议坚持华盛顿大学机构审查委员会的指导方针。 1，电生理评估<ol><li>会议的制备<ol><li>机房准备：地方manipulandum（ 见图1），附带一个传感器，它发送一个带有时间戳标记采集软件，当它被抓住，在表中抓参与者接触木块。激活脑电信号采集软件，并开始“新的会话”（ 图S1）。 </li><li>扣除准备：蒸馏水（1升），氯化钾（1汤匙），和婴儿洗...

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成功收购，加工和分析相关的万亩节奏和应用临床人群电数据需要1个）的脑电图方法工具的应用，2）仔细神器检测和数据还原，3）准确识别亩节奏，和4）的临床群体以及确定适当的对照组的准确表征。 适当的脑电图方法需要正常运作和集成设备，适当帽的选择和布局，信号的精确放大和时序，明确，畅通，无失真的信号，适当参考的信号，适当分段（...

脑电图（EEG）是评估和记录大脑活动的有效，高效，无创方法。作为神经元激发在大脑中，所产生的电压可以被放大，记录，并以图形方式表示。脑电图的时间分辨率允许在大脑的振荡模式，即使短暂的变化，以及大脑的响应特定刺激的分析的分析。 尽管是历史最悠久的大脑成像技术，其历史可以追溯到19 世纪后期，脑电图仍具有广泛的适用性。而功能性磁共振成像（fMRI）具有优良的空间分辨率，它具有相对较差的时间分辨率。这代表了功能磁共振成像评估的主要限制给出的令人难以置信的速度，发生在大脑的进程。脑电图有毫秒级评估电气大脑活动的能力，提供了潜在的Insight入脑的处理的各个阶段。 日新月异的技术也扩大了脑电图的适用性。在记录系统的密​​度的增加使得对源定位技术的发展，减轻对于空间分辨率的一些脑电图的局限性。另外，先进的系统已经减少了单个参与者建立时间显著，允许以前没有的人群，如婴幼儿及临床样品1-3,28-30的评估。 鉴于良好的时间分辨率，脑电图可以用来检查与特定的行为，状态或外界刺激的神经反应。该实用程序的一个例子是镜像神经元系统（MNS）在人体中的评估。镜像神经元最初在猴子身上发现使用单神经元记录4，证明一组神经元的反应既执行和观察电机动作。将电极在大脑中的这种直接记录方法，在人类中，只有在恶劣的临床病例中很少使用。脑电图已经提供了一种通过监测脑电图亩节奏评估MNS。在8-12赫兹范围该振荡模式已显示出减弱的EEG功率响应于执行和观察马达的动作，类似于在猴子5-7中观察到的激活模式。同样，通过经颅磁刺激（ 如额下回）刺激假定MNS脑区的脑电废除节奏万亩和8万亩脑电节律抑制与相关脑功能成像的科目9中公认的镜像神经元区域BOLD信号，提供额外的支持，这节奏索引，至少部分地，MNS活性。脑电图亩节奏评估允许的镜像神经元作为的无创性评估ivity在人。 脑电图为研究大脑活动的唯一方法，当与基于行为的检测相结合，它可以是一个强大的工具，阐明社会认知方面，如模仿，在临床人群。此外，脑电图与人群的认知或语言障碍使用的适用性允许洞察个人对他们来说，其他成像技术或行为范式可能不太成功运用的能力。所描述的协议提供了一个途径，研究社会认知功能理论上链接到镜像神经元系统中具有典型和非典型的发展，如自闭症的人。

<table border="0" cellpadding="0" cellspacing="0" width="994">
	<tbody>
		<tr height="21">
			<td height="21" style="height:21px;width:267px;">Geodesic EEG System</td>
			<td style="width:71px;">EGI</td>
			<td style="width:119px;">N/A</td>
			<td style="width:539px;">Any EEG system, not only EGI based systems, is applicable for the described study</td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:267px;">MATLAB software</td>
			<td style="width:71px;">MATLAB</td>
			<td style="width:119px;">N/A</td>
			<td>Any mathematical, statistical software that can work with matrices is applicable</td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:267px;">Netstation software</td>
			<td style="width:71px;">EGI</td>
			<td style="width:119px;">N/A</td>
			<td>Any EEG acquisition software is applicable for the described study</td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:267px;">Manipulandum</td>
			<td style="width:71px;">custom</td>
			<td style="width:119px;">N/A</td>
			<td>Any object that is co-registered with data acquisition software to signal a successful grasp</td>
		</tr>
	</tbody>
</table>

eeg mu rhythm in typical and atypical development

脑电图（EEG）是评估和记录大脑活动的有效，高效，无创方法。鉴于良好的时间分辨率，脑电图可以用来检查与特定的行为，状态或外界刺激的神经反应。该实用程序的一个例子是镜像神经元系统（MNS）在人类通过脑电图亩节奏的检查评估。脑电图亩的节奏，从位于市中心的电极记录在8-12赫兹的频率范围内振动的活性，抑制当一个人执行时，或者干脆指出，目标导向行动。因此，已经提出，以反映MNS的活性。据推测，在镜像神经元系统（MNS）功能障碍中起着自闭症谱系障碍（ASD）的社会赤字贡献作用。该MNS然后可以通过使用脑电图亩节奏衰减为指标，对其活动进行无创检查在临床人群。所描述的普罗特OCOL提供了一个途径是观察社会的认知功能与典型的和非典型的发展，如房间隔缺损的个体理论上链接到MNS。

典型成人，儿童和婴幼儿的范式既执行和观察的行为在各种刺激和5，14-30期间一贯表现亩节奏。衰减在该频段频率一致本地化跨越中央电极（ 图3），表明这不是减少它被记录在其他的头皮区域阿尔法权力。类似地，在观察运动的衰减在这个频率被限制到观察的基于生物学的运动和抑制的是不是简单地从运动引起穿过视场，如弹跳球（ 图4）。亩抑制响应于一个事...

Watch this Scientific Journal Video about EEG Mu Rhythm in Typical and Atypical Development at JoVE.com

EEG Mu Rhythm in Typical and Atypical Development

脑电图亩节奏评估为研究大脑活动的唯一方法，当与基于行为的检测相结合，可以是一个强大的工具，阐明社会认知方面，如模仿，在临床人群。

脑电图沐节奏典型和非典型发展

Electroencephalography (EEG) is an effective, efficient, and noninvasive method of assessing and recording brain activity. Given the excellent temporal ...

Research

JoVE Journal

Medicine

Direct Pressure Monitoring Accurately Predicts Pulmonary Vein Occlusion During Cryoballoon Ablation

直接压力监测准确预测在Cryoballoon消融肺静脉阻塞

Cryoballoon  ablation (CBA) is an established therapy for atrial fibrillation (AF).  Pulmonary vein (PV) occlusion is essential for achieving antral ...

科研

医学

Development of an Audio-based Virtual Gaming Environment to Assist with Navigation Skills in the Blind

基于音频的虚拟游戏环境的发展，以帮助盲人的导航技巧

Audio-based Environment Simulator (AbES) is virtual environment software designed to improve real world navigation skills in the blind. Using only audio ...

Clinical Examination Protocol to Detect Atypical and Classical Scrapie in Sheep

临床检查协议检测非典型和经典刮在绵羊

The diagnosis of scrapie, a transmissible spongiform encephalopathy (TSEs) of sheep and goats, is currently based on the detection of disease-associated ...

Assessment of Ovarian Cancer Spheroid Attachment and Invasion of Mesothelial Cells in Real Time

在实时的间皮细胞卵巢癌球体附件和入侵评估

Ovarian cancers metastasize by shedding into the peritoneal fluid and dispersing to distal sites within the peritoneum. Monolayer cultures do not ...

Real-time Cytotoxicity Assays in Human Whole Blood

实时的细胞毒性分析在人全血

A live cell-based whole blood cytotoxicity assay (WCA) that allows access to temporal information of the overall cell cytotoxicity is developed with ...

Brain Source Imaging in Preclinical Rat Models of Focal Epilepsy using High-Resolution EEG Recordings

采用高分辨率脑电图记录脑源成像局灶性癫痫的临床前模型大鼠

Electroencephalogram (EEG) has been traditionally used to determine which brain regions are the most likely candidates for resection in patients with ...

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody (mAb) by Neutralizing TNF Using an In Vitro Bioanalytical Method

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody mAb by Neutralizing TNF Using an In Vitro Bioanalytical Method

使用体外生物法测定抗 tnf 单克隆抗体 (抗体) 的相对效力

This protocol shows the measurement of the apoptotic activity neutralization of TNF&#945; in a mouse fibroblast cell model (WEHI 164) using an ...

Assessment of Spontaneous Alternation, Novel Object Recognition and Limb Clasping in Transgenic Mouse Models of Amyloid-&#946; and Tau Neuropathology

Assessment of Spontaneous Alternation, Novel Object Recognition and Limb Clasping in Transgenic Mouse Models of Amyloid-ÃƒÆ’Ã…Â½Ãƒâ€šÃ‚Â² and Tau Neuropathology

自发交替评估，淀粉样蛋白β和脑神经病理学转基因小鼠模型中的新物体识别和肢体紧扣

Here we describe a staged, behavioral testing approach that can be used to screen for compounds that exhibit in vivo efficacy on cognitive and functional ...

The Pilocarpine Model of Temporal Lobe Epilepsy and EEG Monitoring Using Radiotelemetry System in Mice

小鼠颞叶癫痫的 Radiotelemetry 模型及脑电图监测

Temporal lobe epilepsy (TLE) is a common neurological disorder in adulthood. For translational studies of chronic epilepsy, pilocarpine-induced status ...

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

小鼠致耐受性树突状细胞的发育及功能表征

The immune system operates by maintaining a tight balance between coordinating responses against foreign antigens and maintaining an unresponsive state ...