Name: eeg mu rhythm in typical and atypical development
Uploaded: 2014-04-09T22:15:00
Description: Watch this Scientific Journal Video about EEG Mu Rhythm in Typical and Atypical Development at JoVE.com

Dette arbejde blev støttet af en bevilling fra Simons Foundation (SFARI # 89638 til RB).

Følgende protokol følger retningslinjerne fra University of Washington Institutional Review Board. 1.. Elektrofysioloqisk Assessment <ol><li> Udarbejdelse af Session <ol><li> Room forberedelse: Placer manipulandum (se figur 1), en træklods med en sensor knyttet, som sender en tidsstemplet markør til erhvervelse software, når den gribes, på bordet inden gribe rækkevidde af deltageren. Aktiver EEG erhvervelse software og begynde &quot;ny session&quot; (Figur S...

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Den vellykkede køb, forarbejdning, og analyse af elektrofysiologiske data relateret til mu rytme og ansøgningen til kliniske populationer kræver 1) anvendelsen af ​​EEG metodiske redskaber, 2) omhyggelig artefakt opdagelse og reduktion af data, 3) nøjagtig identifikation af mu rytme, og 4) nøjagtig karakterisering af kliniske befolkning og identifikation af egnede kontrolgrupper. Passende EEG metoden kræver velfungerende og integreret udstyr, passende lo...

Electroencefalografi (EEG) er en effektiv, effektiv og ikke-invasiv metode til vurdering og registrering hjernens aktivitet. Neuroner brand i hjernen, kan den resulterende spænding skal forstærkes, registreres og grafisk. Den tidsmæssige opløsning af EEG giver mulighed for analyse af selv kortvarige ændringer i svingningsmønstre i hjernen, såvel som analyse af hjernens respons på specifikke stimuli. På trods af at den ældste brain imaging teknik, der går tilbage til slutningen af det 19. århundrede, EEG stadig har bred anvendelighed. Mens funktionel magnetisk resonans (fMRI) har fremragende rumlig opløsning, har det relativt dårlige tidsmæssige opløsning. Dette udgør en væsentlig begrænsning af fMRI vurdering givet den utrolige hastighed, hvormed processer forekommer i hjernen. EEG har evnen til at vurdere hjernens elektriske aktivitet på millisekund niveau, hvilket giver potentiale insight i faserne i hjernens forarbejdning. Udviklende teknologier har også udvidet anvendeligheden af ​​EEG. En stigning i tætheden af ​​registreringssystemer har muliggjort udviklingen af ​​kilde lokaliserings teknikker afbøde nogle af EEG begrænsninger med hensyn til rumlig opløsning. Derudover har moderne systemer reduceret den enkelte deltager set-up tid betydeligt, giver mulighed for vurdering af tidligere utilgængelige befolkningsgrupper, såsom spædbørn og kliniske prøver 1-3,28-30. I betragtning af den fremragende tidsmæssige opløsning, kan EEG bruges til at undersøge de neurale respons relateret til specifikke adfærd, stater eller eksterne stimuli. Et eksempel på dette værktøj er vurderingen af ​​spejlet neuron systemet (MNS) hos mennesker. Spejlneuroner blev oprindeligt identificeret i aber anvendes enkelt neuron optagelse 4, der dokumenterer en gruppe afneuroner, der responderede på både udførelse og observation af motoriske handlinger. Denne direkte optagelse metode til at placere elektroder i hjernen er sjældent brugt i mennesker, og kun i alvorlige kliniske tilfælde. EEG har givet en metode til vurdering af de MNS ved at overvåge EEG mu rytme. Denne svingning mønster i 8-12 Hz har vist sig at dæmpe EEG magt som svar på udførelse og observation af motoriske handlinger, svarende til aktivering mønster observeret i aber 5-7. Ligeledes stimulering af formodede MNS hjerneregioner gennem Transcranial magnetisk stimulation (f.eks ringere frontal gyrus) afskaffer EEG mu rytme 8 og EEG mu rytme undertrykkelse korrelerer med BOLD signaler fra fMRI i formodede spejl neuron regioner i fag 9, yde ekstra støtte, at denne rytme indekser, i det mindste delvist, MNS aktivitet. Vurdering af EEG mu rytme har tilladt for en noninvasiv vurdering af spejl neuron handlingivity hos mennesker. EEG giver en unik metode til at undersøge hjernens aktivitet og når det kombineres med adfærdsmæssigt baserede assays, kan det være et effektivt redskab til at belyse aspekter af social kognition, såsom imitation, i kliniske populationer. Endvidere anvendeligheden af ​​EEG til brug med befolkninger med kognitive eller sprogforstyrrelser giver mulighed for indsigt i evner af personer, for hvem andre billeddiagnostiske teknikker eller adfærdsmæssige paradigmer kan være mindre held udnytte. Den beskrevne protokol giver en mulighed for at undersøge de sociale kognitive funktioner teoretisk knyttet til spejlet neuron system individer med typisk og atypisk udvikling, såsom autismespektrumforstyrrelser.

<table border="0" cellpadding="0" cellspacing="0" width="994">
	<tbody>
		<tr height="21">
			<td height="21" style="height:21px;width:267px;">Geodesic EEG System</td>
			<td style="width:71px;">EGI</td>
			<td style="width:119px;">N/A</td>
			<td style="width:539px;">Any EEG system, not only EGI based systems, is applicable for the described study</td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:267px;">MATLAB software</td>
			<td style="width:71px;">MATLAB</td>
			<td style="width:119px;">N/A</td>
			<td>Any mathematical, statistical software that can work with matrices is applicable</td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:267px;">Netstation software</td>
			<td style="width:71px;">EGI</td>
			<td style="width:119px;">N/A</td>
			<td>Any EEG acquisition software is applicable for the described study</td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:267px;">Manipulandum</td>
			<td style="width:71px;">custom</td>
			<td style="width:119px;">N/A</td>
			<td>Any object that is co-registered with data acquisition software to signal a successful grasp</td>
		</tr>
	</tbody>
</table>

eeg mu rhythm in typical and atypical development

Electroencefalografi (EEG) er en effektiv, effektiv og ikke-invasiv metode til vurdering og registrering hjernens aktivitet. I betragtning af den fremragende tidsmæssige opløsning, kan EEG bruges til at undersøge de neurale respons relateret til specifikke adfærd, stater eller eksterne stimuli. Et eksempel på dette værktøj er vurderingen af ​​spejlet neuron systemet (MNS) i mennesker gennem undersøgelse af EEG mu rytme. EEG mu rytme, oscillerende aktivitet i 8-12 Hz frekvensområde optaget fra centralt placerede elektroder, er undertrykt, når en person udført, eller blot bemærker, instrueret mål handlinger. Som sådan har det været foreslået at afspejle aktiviteten af ​​MNS. Det er blevet teoretiseret, at dysfunktion i spejlet neuron systemet (MNS) spiller en medvirkende rolle i de sociale underskud autisme spektrum forstyrrelse (ASF). MNS kan derefter noninvasively undersøgt i kliniske populationer ved hjælp af EEG mu rytme dæmpning som et indeks for aktiviteten. Den beskrevne protocol giver en mulighed for at undersøge de sociale kognitive funktioner teoretisk knyttet til MNS i individer med typisk og atypisk udvikling, som ASF.

Typiske voksne, børn og spædbørn har konsekvent demonstreret mu rytme både under udførelse og observation af handlinger på tværs af forskellige paradigmer og stimuli 5, 14-30. Dæmpning i dette frekvensbånd er konsekvent lokaliseret på tværs af centrale elektroder (figur 3), der angiver, at dette ikke er reduktion af alfa magt, som er optaget på andre hovedbund regioner. Ligeledes er dæmpning i denne frekvens under observation af bevægelse begrænset til observation af biologisk ...

Watch this Scientific Journal Video about EEG Mu Rhythm in Typical and Atypical Development at JoVE.com

EEG Mu Rhythm in Typical and Atypical Development

Vurdering af EEG mu rytme giver en unik metode til at undersøge hjernens aktivitet og når det kombineres med adfærdsmæssigt baserede assays, kan være et effektivt redskab til at belyse aspekter af social kognition, såsom imitation, i kliniske populationer.

EEG Mu Rhythm i Typisk og atypisk udvikling

Electroencephalography (EEG) is an effective, efficient, and noninvasive method of assessing and recording brain activity. Given the excellent temporal ...

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