Name: network analysis of the default mode network using functional connectivity mri in temporal lobe epilepsy
Uploaded: 2014-08-05T14:00:00
Description: Watch this Scientific Journal Video about Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy at JoVE.com

Finansieringen af denne forskning blev leveret af Epilepsi Foundation of America, Baylor College of Medicine Computational og Integrativ Biomedical Research Center (CIBR) Frø Grant Awards (ZH), NIH-NINDS K23 Grant NS044936 (JMS); . og The Leff Family Foundation (JMS) Dataopsamling blev bistået af: Elizabeth Pierce (UCLA).

1. Emner <ol><li> Undersøgelsen befolkning på 36 forsøgspersoner omfatter 3 grupper: højre TLE (n = 11), venstre TLE (n = 12) og raske kontroller (n = 13). Indhente skriftligt informeret samtykke fra alle fag. Undersøgelsen følger retningslinjerne fra University of California, Los Angeles (UCLA) Institutional Review Board. </li><li> Epilepsien faggrupper bør være patienter, der er kandidater til anterior tindingelappen resektion som bestemt ved hjælp af video-EEG overvågning, hjerne MRI, PET billedbehandling...

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Epilepsi menes at være et netværk sygdom og abnormiteter i de involverede netværk er til stede under anfald og interictal tilstand 21. Task-baserede fMRI er blevet anvendt til at analysere abnormiteter i sprog og hukommelse net TLE 8. FcMRI har iboende fordele i at studere DMN 12, da det er et netværk primært aktiv i hviletilstand. DMN er et netværk af områder af hjernen, der har vist sig at være aktive i vågne personer, der er uforstyrret og er engageret i spontane tanker. Diss...

Funktionel Connectivity MRI (fcMRI) er en forholdsvis ny analytisk tilgang til fMRI data, der kvantificerer sammenhængen mellem de forskellige områder i hjernen baseret på ligheden mellem deres blodets iltning niveau afhængig signal serie (FED) tid - dette kaldes &quot;funktionel&quot; tilslutning, og er skelnes fra anatomisk konnektivitet, der beskriver eksistensen af fysiske forbindelser mellem regioner (f.eks hvide substans fibre). I en særlig anvendelse af denne fremgangsmåde, er tidsserien indsamles, når deltageren ikke er involveret i en opgave eller er i den såkaldte &quot;hvile tilstand&quot;. Selvom første gang beskrevet i 1995 1, har der været en enorm interesse i fcMRI resulterer i cirka 1.000 publikationer i forbindelse med teknikken i 2012. FcMRI har iboende fordele i forhold til task-baseret fMRI i (1), at der ikke er nogen specifik opgave, der skal udføres, ( 2) emne samarbejde erikke nødvendigt, (3) datasæt kan anvendes til at forespørge flere forskellige netværk (4) bedre signal-støj-forhold er til stede sandsynligvis på grund af forskelle i cerebrale energetik involveret, og (5) omgåelse af opgavemæssige confounds 2. Som et bevis på sit koncept, er blevet vist fcMRI ændringer at korrespondere med ændringer i EEG 3 og lokale feltpotentialer 4 i hjernen. Teknikker til fcMRI analysen indeholde ROI / frø-baserede teknikker, uafhængig komponent analyse (ICA), grafteori analyse, Granger kausalitet analyse, lokale metoder (amplitude udsving lav frekvens, regional homogenitet analyse), og andre 5. Ingen enkelt teknik har endnu vist klar overlegenhed over en anden, selv om de mest populære metoder er frø-baserede og ICA-metoder 6. Seed-baserede fcMRI korrelerer tidsmæssige udsving i BOLD signal fra en forvalgt del af det formodede netværk under undersøgelse betegnes &quot;seed1; eller &quot;region af interesse (ROI)&quot; til alle andre dele af hjernen. Områder af hjernen viser BOLD signal korrelerende til frøet område menes at afgrænse dele af de involverede netværk. I modsætning hertil bruger ICA en model-fri datastyret analyse til at udtrække spatio-tidsmæssigt korrelerede områder i hjernen (Independent Komponenter, ICS) ved at analysere de hæmodynamiske signal karakteristika hele hjernen 5.. I den nuværende manuskript er en beskrivelse af metoder, der anvendes i en tidligere offentliggjort undersøgelse af hviletilstand frø-baserede konnektivitet analyse af DMN i FLE præsenteret 7. TLE er den mest almindelige form for voksen epilepsi. Ud over anfald, TLE forårsager dysfunktion af flere hjernens netværk, herunder hukommelse, adfærd, tanker og sensorisk funktion 8. DMN udgøres af cerebrale regioner subserving bevidst, hvile-state kognition. DMN er blevet rapporteret at være involveret i anfald forbundet med reduceret consciousness 9,10. Derudover hippocampus er nøglen struktur involveret i TLE og er blevet anset for at være del af DMN. Men forbinde PCC til hippocampusformationen er svagere end med andre DMN komponenter, såsom mediale præfrontale og ringere parietale cortex. Dette antyder, at hippocampus er enten et undernetværk DMN eller interagerende netværk 11,12. Disse fællestræk mellem TLE og DMN hæve muligheden for, at DMN funktionelle konnektivitet er ændret i FLE. Denne analyse sammenligner DMN af forsøgspersoner med TLE til raske kontrolpersoner at få indsigt i inddragelse af DMN i FLE. Forbinde frø placeret i de vigtigste knudepunkter i DMN - de forreste og bageste hub regioner blev analyseret 12. Frøene blev placeret i den bageste nav bestående af retrosplenium / precuneus (Rsp / PCUN) samt den forreste nav bestående af ventromedial præfrontale cortex (vmPFC) hos patienter med TLE ograske kontrolpersoner at identificere de bageste og forreste subnetværk af DMN.

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			<td>MRI machine</td>
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			<td>Linux workstation with image analysis software installed</td>
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network analysis of the default mode network using functional connectivity mri in temporal lobe epilepsy

Funktionel konnektivitet MRI (fcMRI) er en fMRI metode, der undersøger tilslutning af forskellige områder i hjernen baseret på korrelation af BOLD signal udsving over tid. FLE (TLE) er den mest almindelige form for voksen epilepsi og involverer flere netværk i hjernen. Standardtilstanden netværk (DMN) er involveret i bevidst hviletilstand kognition og menes at være påvirket i TLE hvor anfald medføre forringelse af bevidsthed. DMN i epilepsi blev undersøgt ved hjælp af frø baserede fcMRI. De forreste og bageste knudepunkter i DMN blev brugt som frø i denne analyse. Resultaterne viser en afbrydelse mellem den forreste og bageste knudepunkter i DMN i FLE under den basale tilstand. Desuden øgede DMN forbindelse til andre områder af hjernen i venstre TLE sammen med nedsat tilslutningsmuligheder i højre TLE er afsløret. Analysen viser, hvordan frø-baserede fcMRI kan anvendes til at probe cerebrale net hjernesygdomme såsom TLE.

Figur 1 viser DMN afsløret med tilslutning fra en posterior frø (RSP / PCUN, rød-gule farver) og en forreste frø (vmPFC, blå-grønne farver), og sammenligner de netværk, der findes i de forskellige faggrupper (figur 1A-C) og mellem hinanden, nemlig raske kontroller i forhold til alle patienter med TLE (figur 1D og 1E), og derefter raske kontroller sammenlignet separat til venstre TLE (figur 1F og 1G) og højre TLE...

Watch this Scientific Journal Video about Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy at JoVE.com

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Standardtilstanden Network (DMN) ved FLE (TLE) er analyseret i den hvilende tilstand af hjernen ved hjælp af frø-baserede funktionelle konnektivitet MRI (fcMRI).

Netværk Analyse af standardtilstanden netværk ved hjælp af Funktionel Connectivity MRI ved FLE

Functional connectivity MRI (fcMRI) is an fMRI method that examines the connectivity of different brain areas based on the correlation of BOLD signal ...

Research

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Medicine

Generation of Subcutaneous and Intrahepatic Human Hepatocellular Carcinoma Xenografts in Immunodeficient Mice

Generering af Subkutan og Intrahepatisk Menneskelige hepatocellulært carcinom xenotransplantater i immunsvækkede mus

In  vivo experimental models of hepatocellular carcinoma (HCC) that recapitulate  the human disease provide a valuable platform for research into disease  ...

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Udvikling Neuroimaging fænotyper af standardtilstanden Network i PTSD: Integration hviletilstand, arbejdshukommelse, og Strukturel Connectivity

Complementary structural and functional neuroimaging techniques used to examine the Default Mode Network (DMN) could potentially improve assessments of ...

In Vivo and Ex Vivo Approaches to Study Ovarian Cancer Metastatic Colonization of Milky Spot Structures in Peritoneal Adipose

In Vivo and Ex Vivo Approaches to Study Ovarian Cancer Metastatic Colonization of Milky Spot Structures in Peritoneal Adipose

In vivo og ex vivo Approaches at studere kræft i æggestokkene Metastatisk Kolonisering af Milky Spot Strukturer i peritoneal Adipose

High-grade serous ovarian cancer (HGSC), the cause of widespread peritoneal metastases, continues to have an extremely poor prognosis; fewer than 30% of ...

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder

MR-guided dmPFC-rTMS som en behandling for behandling-resistent depression

Here we outline the protocol for magnetic resonance imaging (MRI) guided repetitive transcranial magnetic stimulation (rTMS) to the dorsal medial ...

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

En Multimodal Imaging- og Stimulation-baserede metode til at evaluere Connectivity-relaterede Brain uro hos patienter med epilepsi

Resting-state functional connectivity MRI (rs-fcMRI) is a technique that identifies connectivity between different brain regions based on correlations ...

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Netværk Analyse af foramen ovale elektrode Optagelser i Drug-resistent TLE Patienter

Approximately 30% of epilepsy patients are refractory to antiepileptic drugs. In these cases, surgery is the only alternative to eliminate/control ...

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Opløseligheden af hydrofobe forbindelser i vandig opløsning ved hjælp af kombinationer af selvstændige montage peptid og aminosyre

Self-assembling peptides (SAPs) are promising vehicles for the delivery of hydrophobic therapeutics for clinical applications; their amphipathic ...

The Pilocarpine Model of Temporal Lobe Epilepsy and EEG Monitoring Using Radiotelemetry System in Mice

Pilocarpin Model af frontal-lap epilepsi og EEG overvågning ved hjælp af Radiotelemetry System i mus

Temporal lobe epilepsy (TLE) is a common neurological disorder in adulthood. For translational studies of chronic epilepsy, pilocarpine-induced status ...

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI&#8212;Application in Premanifest Huntington's Disease

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRIÃƒÆ’Ã‚Â¢ÃƒÂ¢Ã¢â‚¬Å¡Ã‚Â¬ÃƒÂ¢Ã¢â€šÂ¬Ã‚ÂApplication in Premanifest Huntington's Disease

Hele-hjerne segmentering og Change-point analyse af anatomiske hjerne MRI-program i premanifeste Huntington's chorea

Recent advances in MRI offer a variety of useful markers to identify neurodegenerative diseases. In Huntington&#39;s disease (HD), regional brain atrophy ...

Harvest of Endothelial Cells from the Balloon Tips of Swan-Ganz Catheters after Right Heart Catheterization

Høst i Endothelial Cells fra ballon Tips af Swan-Ganz katetre efter højre hjerte kateterisation

A variety of pathologies lead to pulmonary hypertension (PH), which is defined as a mean pulmonary artery pressure exceeding 25 mmHg at rest. To further ...