新生児マウスの脳室下帯へのプラスミドDNAのトランスポゾン媒介統合は、神経膠芽腫の新規モデルを生成する

Here we describe an efficient and versatile protocol to induce, monitor and analyze novel glioblastomas (GBM) using transposon DNA injected into the ventricles of neonatal mice. Cells of the subventricular zone, which take up the plasmid, transform, proliferate and generate tumors with histo-pathological characteristics of human GBM.