Roman Atomic Force Microscopy Based Biopanning voor isolatie van morfologie specifieke reagentia tegen TDP-43 Varianten in Amyotrofische Lateraal Sclerose

Using atomic force microscopy in combination with biopanning technology we created a negative and positive biopanning system to acquire antibodies against disease-specific protein variants present in any biological material, even at low concentrations. We were successful in obtaining antibodies to TDP-43 protein variants involved in Amyotrophic Lateral Sclerosis.