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רומן הכוח האטומי מיקרוסקופית מבוסס Biopanning לבידוד של חומרים כימיים מסוימים מורפולוגיה נגד גרסאות TDP-43 בטרשת לרוחב amyotrophic

DOI :

10.3791/52584-v

February 12th, 2015

February 12th, 2015

8,640 Views

1School for Engineering of Matter, Transport and Energy, Arizona State University, 2Department of Neurology, Georgetown University Medical Center, 3Department of Pathology, Georgetown University Medical Center

Using atomic force microscopy in combination with biopanning technology we created a negative and positive biopanning system to acquire antibodies against disease-specific protein variants present in any biological material, even at low concentrations. We were successful in obtaining antibodies to TDP-43 protein variants involved in Amyotrophic Lateral Sclerosis.

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