सिंथेटिक प्रोटीन के अनुकूलन: Interpositional निर्भरता की पहचान संरचनात्मक संकेत है और / या कार्यात्मक लिंक्ड अवशेष

Synthetic protein sequences based on consensus motifs typically ignore co-evolving residues, that imply interpositional dependencies (IPDs). IPDs can be essential to activity, and designs that disregard them may result in suboptimal results. This protocol uses StickWRLD to identify IPDs and help inform rational protein design, resulting in more efficient results.