Name: a mouse model of subchronic and mild social defeat stress for understanding stress-induced behavioral and physiological deficits
Uploaded: 2015-11-24T14:00:00
Description: Watch this Scientific Journal Video about A Mouse Model of Subchronic and Mild Social Defeat Stress for Understanding Stress-induced Behavioral and Physiological Deficits at JoVE.com

De auteurs danken Drs. Kentaro Nagaoka (Tokyo University of Agriculture and Technology) en Wataru Iio (Ibaraki) voor de behulpzame discussie. Dit onderzoek werd mede ondersteund door Ibaraki Universitaire Samenwerking tussen Landbouw en Medische Wetenschappen (IUCAM) (De MEXT, Japan) en het Research Project op de ontwikkeling van landbouwproducten en voedingsmiddelen met Gezondheidsbevorderende Benefits (NARO) (Het MAFF, Japan) .

De dierproeven werden goedgekeurd door en ontmoette de richtlijnen van zowel de Animal Care en gebruik Comite van Ibaraki Universiteit en het Ministerie van Onderwijs, Cultuur, Sport, Wetenschap en Technologie (MEXT), Japan (Notification No.71). Een volledig overzicht van het protocol wordt getoond in figuur 1. 1. Inrichting <ol><li> Bereid twee soorten kooien: een kooi (breedte [W] × diepte [D] × hoogte [H] = 143 mm x 293 mm x 148 mm), en een &quot;sociaal nederlaag (SD...

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Er waren definitieve verschil in lichaamsgewicht tussen sCSDS muizen en CSDS muizen blootgesteld aan de standaard CSDS protocol (5-10 min van fysiek contact met de aanvallers per dag) 19. De sCSDS muizen vertoonden verhoogde BWG tijdens de stress periode, terwijl de standaard CSDS muizen vertoonden een afname in lichaamsgewicht tijdens de stress periode 21,22,23. Er is een aanzienlijk verschil tussen de twee protocollen met betrekking tot de totale duur van fysiek contact met aanvallers tijdens de ...

Vele soorten van stressvolle gebeurtenissen plaatsvinden gedurende het leven van de mens. Overmatige stress leidt vaak tot schadelijke fysiologische gevolgen bij mens en dier. Bij de mens, stressvolle gebeurtenissen zijn belangrijke risicofactoren neerslaan psychiatrische stoornissen zoals depressie 1. Een Global Burden of Disease studie bleek dat depressie is een van de meest invaliderende aandoeningen in termen van disability adjusted life years (DALY&#39;s) en jaren geleefd met een handicap 2. Daarnaast, depressie is goed voor het grootste deel van de zelfmoord DALY 3. Mensen die lijden aan depressie moeilijk om hun leven te beheren, en daardoor hun levenskwaliteit verergert vaak. Daarom is er een sterke behoefte aan effectieve therapieën voor de kwaliteit van leven van deze patiënten te verbeteren. Veel studies zijn uitgevoerd op depressieve stoornissen, en is gebleken dat de genetische bijdrage aan de ziekte susceptibility is ongeveer 30-40%, wat verklaard door de effecten van meervoudige loci van kleine effecten 4. Vanwege de complexe pathogene mechanismen die ten grondslag liggen aan depressie, de gedetailleerde etiologie van de ziekte blijft ongrijpbaar. Klinische rapporten geven aan dat er subtypes van depressies, zoals melancholische en atypische depressie 5, waaruit blijkt verlaagde en verhoogde lichaamsgewicht, respectievelijk 6. Hoewel 25-30% en 15-30% van de patiënten met depressie vertegenwoordigen pure melancholische en atypische kenmerken, respectievelijk, de meeste van hen hebben gemengde kenmerken van beide subtypes 7. Daarom depressie heeft een breed scala van symptomen. Om biomarkers en objectieve therapeutica voor de verschillende vormen van depressie bij mensen te ontwikkelen, is het belangrijk om een aantal verschillende diermodellen van depressie 8 vast. Diermodellen van depressie zijn vastgesteld met behulp van verschillende benaderingen zoals geleerdhulpeloosheid, chronische onvoorspelbare milde stress en chronische sociale nederlaag stress (CSD&#39;s) 9-12. Toyoda en collega vestigde de CSDS modellen van ratten en muizen 13-17 om de stofwisseling en gedragingen die worden geassocieerd met depressie helderen. Aangezien diermodellen van depressie geëvalueerd door gezicht geldigheid 18, de context waarin het model wordt vastgesteld van belang. Bovendien Golden et al. 19 meldde de methoden voor het creëren CSDS muizen in detail. Het is bekend dat de tekorten in sociaal gedrag CSDS muizen kan worden gewonnen door chronische behandeling, maar niet acute behandeling met antidepressiva, en dat zij symptomen vergelijkbaar met die bij patiënten met een depressie delen wat betreft de regulering van de hersenen afgeleide neurotrofe factor 6. Goto et al. 13 eerder ontwikkelde de subchronische en milde sociale nederlaag stress (sCSDS) muismodel door wijziging van de methodenGolden et al. 19. De sCSDS muizen tonen polydipsia- en hyperfagie-achtige symptomen na winst in lichaamsgewicht en een verhoogde body watergehalte 13. In dit rapport wordt het protocol voor het vaststellen van de sCSDS muismodel verstrekt en bespreken we het nut van dit model.

<table border="0" cellpadding="0" cellspacing="0">
	<tbody>
		<tr>
			<td>single cage</td>
			<td>Charles River Laboratories Japan</td>
			<td></td>
			<td>width [W] &#215; depth [D] &#215; height [H] = 143 &#215; 293 &#215; 148 mm</td>
		</tr>
		<tr>
			<td>M cage</td>
			<td>Natsume Seisakusho</td>
			<td></td>
			<td>W &#215; D &#215; H = 220 &#215; 320 &#215; 135 mm</td>
		</tr>
		<tr>
			<td>Whiteflake</td>
			<td>Charles River Laboratories Japan</td>
			<td></td>
			<td>Wood-shaving chips made from spruce trees</td>
		</tr>
		<tr>
			<td>AIN-93G</td>
			<td>Oriental Yeast</td>
			<td></td>
			<td>purified-diet food pellets</td>
		</tr>
		<tr>
			<td>Kimtowel</td>
			<td>Nippon Paper Crecia Co.</td>
			<td></td>
			<td>Paper towels</td>
		</tr>
		<tr>
			<td>open-field arena</td>
			<td>O&#8217;Hara &#38; Co.</td>
			<td></td>
			<td>made of gray polyvinylchloride</td>
		</tr>
	</tbody>
</table>

a mouse model of subchronic and mild social defeat stress for understanding stress-induced behavioral and physiological deficits

Stressful life events often increase the incidence of depression in humans. To study the mechanisms of depression, the development of animal models of depression is essential. Because there are several types of depression, various animal models are needed for a deeper understanding of the disorder. Previously, a mouse model of subchronic and mild social defeat stress (sCSDS) using a modified chronic social defeat stress (CSDS) paradigm was established. In the paradigm, to reduce physical injuries from aggressors, the duration of physical contact between the aggressor and a subordinate was reduced compared to in the original CSDS paradigm. sCSDS mice showed increased body weight gain, food intake, and water intake during the stress period, and their social behaviors were suppressed after the stress period. In terms of the face validity of the stress-induced overeating and overdrinking following the increased body weight gain, the sCSDS mice may show some features related to atypical depression in humans. Thus, a mouse model of sCSDS may be useful for studying the pathogenic mechanisms underlying depression. This protocol will help establish the sCSDS mouse model, especially for studying the mechanisms underlying stress-induced weight gain and polydipsia- and hyperphagia-like symptoms.

Om de mate van fysieke stress controleren op via periodes 10 dagen werd het aantal beten aanval door ICR-muizen handmatig geteld door een onderzoeker. Figuur 5A geeft de afzonderlijke waarden voor het aantal beten aanslag ontvangen. Er was een aanzienlijke variabiliteit in het vroege stadium (ongeveer 10-120 beten op dag 1), maar deze variabiliteit is in de latere fase (ongeveer 5-20 beten op dag 10) verminderd. Figuur 5B geeft aan dat het gemiddelde aantal aanvallen beten ontvangen gel...

Watch this Scientific Journal Video about A Mouse Model of Subchronic and Mild Social Defeat Stress for Understanding Stress-induced Behavioral and Physiological Deficits at JoVE.com

A Mouse Model of Subchronic and Mild Social Defeat Stress for Understanding Stress-induced Behavioral and Physiological Deficits

Hier, werkwijzen voor het ontwikkelen van een muismodel van subchronische en milde sociale verslaan spanning beschreven en gebruikt om de pathogène kenmerken van depressie waaronder hyperphagia- en polydipsie-achtige symptomen volgende uitgebreide lichaamsgewicht onderzoeken.

Een muismodel van Subchronische en Mild Sociale Nederlaag Stress voor het begrijpen van stress geïnduceerde Behavioral en Fysiologische Tekorten

Stressful life events often increase the incidence of depression in humans. To study the mechanisms of depression, the development of animal models of ...

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