Name: a mouse model of subchronic and mild social defeat stress for understanding stress-induced behavioral and physiological deficits
Uploaded: 2015-11-24T14:00:00
Description: Watch this Scientific Journal Video about A Mouse Model of Subchronic and Mild Social Defeat Stress for Understanding Stress-induced Behavioral and Physiological Deficits at JoVE.com

Forfatterne takker legene. Kentaro Nagaoka (Tokyo University of Agriculture and Technology) og Wataru iio (Ibaraki Prefecture) for nyttig diskusjon. Denne forskningen ble støttet delvis av Ibaraki Universitetet Samarbeid mellom Landbruks- og Medical Science (IUCAM) (The MEXT, Japan) og forskningsprosjekt om utvikling av landbruksprodukter og matvarer med helsebringende fordeler (NARO) (The MAFF, Japan) .

De dyrestudier ble godkjent av og møtte retningslinjene for både Animal Care og bruk komité Ibaraki University og Kunnskapsdepartementet kultur, sport, vitenskap og teknologi (MEXT), Japan (Notification No.71). En fullstendig oversikt over protokollen er vist i figur 1. 1. Apparat <ol><li> Forbered to typer bur: en enkelt merd (bredde [W] × dybde [D] × høyde [H] = 143 mm × 293 mm × 148 mm), og en &quot;sosial nederlag (SD)&quot; bur (B × D × H = ...

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Det var definitive forskjeller i kroppsvekt mellom sCSDS mus og verdipapirsentraler mus utsatt for standard verdipapirsentraler protokollen (5 til 10 min av fysisk kontakt med overgripere per dag) 19. De sCSDS Musene viste økt BWG i stressperioden, mens de vanlige CSD&#39;ene mus viste en reduksjon i kroppsvekt i løpet av stressperioden 21,22,23. Det er en vesentlig forskjell mellom de to protokollene i form av den totale varigheten av fysisk kontakt med overgripere i løpet av 10-dagers stresspe...

Mange typer stressende hendelser oppstå i hele livet til mennesker. Dreven stress ofte fører til skadelige fysiologiske konsekvenser i mennesker og dyr. Hos mennesker stressende hendelser er viktige risikofaktorer for utfelling av psykiske lidelser som depresjon en. En global Burden of Disease studien indikerte at depresjon er en av de mest invalidiserende lidelser i form av uførejusterte leveår (DALY) og år levd med funksjonshemming to. I tillegg står depresjon for den største andelen av selvmords DALY 3. Personer som lider av depresjon synes det er vanskelig å styre sine liv, og som et resultat, deres livskvalitet ofte forverres. Derfor er det å utvikle effektive behandlingsformer for å bedre livskvaliteten til disse pasientene et sterkt behov. Mange studier har blitt utført på depressive lidelser, og har avslørt at den genetiske bidrag til sykdom ømfintlighet overfory er ca 30-40%, noe som er forklart av effektene av flere loci av små effekter 4. På grunn av de komplekse patogene mekanismene bak depresjon, den detaljerte etiologien av sykdommen fortsatt ukjent. Kliniske rapporter tyder på at det er undertyper av depresjon som melankolsk og atypisk depresjon 5, som viser reduserte og økt kroppsvekt, henholdsvis 6. Selv om 25-30% og 15-30% av pasienter med depresjon representerer rene melankolske og atypiske trekk, henholdsvis, de fleste av dem har blandede funksjoner i begge subtyper 7. Derfor har alvorlig depresjon en lang rekke symptomer. For å finne biomarkører og utvikle objektive terapeutiske midler for forskjellige typer av depresjon hos mennesker, er det viktig å etablere en rekke forskjellige dyremodeller for depresjon 8. Dyremodeller av depresjon er etablert ved hjelp av flere tilnærminger inkludert lærthjelpeløshet, kronisk uforutsigbar mild stress, og kronisk sosialt nederlag stresset (verdipapirsentraler) 9-12. Toyoda og kolleger etablert verdipapirsentraler modeller av rotter og mus 13-17 for å belyse stoffskiftet og atferd som er forbundet med depresjon. Gitt at dyremodeller for depresjon evalueres ved ansikt gyldigheten 18, er den sammenheng som modellen er etablert viktig. Videre gylne et al. 19 rapporterte metodene for å skape verdipapirsentraler mus i detalj. Det er kjent at underskudd i sosial atferd av verdipapirsentraler mus kan utvinnes ved kronisk behandling, men ikke ved akutt behandling, med antidepressiva, og at de deler symptomer som ligner på de i pasienter med depresjon i forhold til regulering av hjerne-nevrotrop faktor 6. Goto et al. 13 tidligere utviklet subkronisk og mild sosial nederlag stresset (sCSDS) musemodell ved å endre metodenefra Golden et al. 19. De sCSDS mus viser polydipsia- og hyperphagia lignende symptomer etter gevinster i kroppsvekt og økt kroppsvanninnhold 13. I denne rapporten er protokollen for å etablere sCSDS musemodell gitt, og vi diskutere nytten av denne modellen.

<table border="0" cellpadding="0" cellspacing="0">
	<tbody>
		<tr>
			<td>single cage</td>
			<td>Charles River Laboratories Japan</td>
			<td></td>
			<td>width [W] &#215; depth [D] &#215; height [H] = 143 &#215; 293 &#215; 148 mm</td>
		</tr>
		<tr>
			<td>M cage</td>
			<td>Natsume Seisakusho</td>
			<td></td>
			<td>W &#215; D &#215; H = 220 &#215; 320 &#215; 135 mm</td>
		</tr>
		<tr>
			<td>Whiteflake</td>
			<td>Charles River Laboratories Japan</td>
			<td></td>
			<td>Wood-shaving chips made from spruce trees</td>
		</tr>
		<tr>
			<td>AIN-93G</td>
			<td>Oriental Yeast</td>
			<td></td>
			<td>purified-diet food pellets</td>
		</tr>
		<tr>
			<td>Kimtowel</td>
			<td>Nippon Paper Crecia Co.</td>
			<td></td>
			<td>Paper towels</td>
		</tr>
		<tr>
			<td>open-field arena</td>
			<td>O&#8217;Hara &#38; Co.</td>
			<td></td>
			<td>made of gray polyvinylchloride</td>
		</tr>
	</tbody>
</table>

a mouse model of subchronic and mild social defeat stress for understanding stress-induced behavioral and physiological deficits

Stressful life events often increase the incidence of depression in humans. To study the mechanisms of depression, the development of animal models of depression is essential. Because there are several types of depression, various animal models are needed for a deeper understanding of the disorder. Previously, a mouse model of subchronic and mild social defeat stress (sCSDS) using a modified chronic social defeat stress (CSDS) paradigm was established. In the paradigm, to reduce physical injuries from aggressors, the duration of physical contact between the aggressor and a subordinate was reduced compared to in the original CSDS paradigm. sCSDS mice showed increased body weight gain, food intake, and water intake during the stress period, and their social behaviors were suppressed after the stress period. In terms of the face validity of the stress-induced overeating and overdrinking following the increased body weight gain, the sCSDS mice may show some features related to atypical depression in humans. Thus, a mouse model of sCSDS may be useful for studying the pathogenic mechanisms underlying depression. This protocol will help establish the sCSDS mouse model, especially for studying the mechanisms underlying stress-induced weight gain and polydipsia- and hyperphagia-like symptoms.

For å overvåke graden av fysisk stress for over 10-dagers perioder, ble antall angreps biter av ICR mus manuelt telles av en forsker. Figur 5A viser de enkelte verdier for antall angreps biter mottatt. Det var betydelig variasjon i tidlig stadium (ca 10-120 biter på dag 1), men denne variasjonen ble redusert i senere stadium (ca 5-20 biter på dag 10). Figur 5B viser at gjennomsnittlig antall angreps biter mottatt gradvis redusert over tid, fordi varigheten av fysisk kontakt redusert...

Watch this Scientific Journal Video about A Mouse Model of Subchronic and Mild Social Defeat Stress for Understanding Stress-induced Behavioral and Physiological Deficits at JoVE.com

A Mouse Model of Subchronic and Mild Social Defeat Stress for Understanding Stress-induced Behavioral and Physiological Deficits

Her er metoder for å utvikle en musemodell for subkronisk og mild sosial nederlag stresset beskrevet og brukt til å undersøke sykdomsfremkallende egenskaper på depresjon inkludert hyperphagia- og polydipsi lignende symptomer etter økt kroppsvekt.

En musemodell for Subkronisk og Mild Social Defeat Stress for Forstå Stress-indusert atferdsmessige og fysiologiske Underskudd

Stressful life events often increase the incidence of depression in humans. To study the mechanisms of depression, the development of animal models of ...

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