Name: combined invasive subcortical and non-invasive surface neurophysiological recordings for the assessment of cognitive and emotional functions in humans
Uploaded: 2016-05-19T13:00:00
Description: Watch this Scientific Journal Video about Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans at JoVE

这项工作是由ERA-NET神经元/ BMBF德国（TYMON）的支持。出版费用由大学医院杜塞尔多夫补助覆盖。这里使用的侧卫任务由C.贝斯特教授和最初版本编程他的研究小组47修改。

星展过程和入侵的录音是由大学医院杜塞尔多夫，德国伦理委员会批准。 1.实验范式设计及病人同意注：设计一个实验范式或者选择现有的实验范式为目标感兴趣的认知/情感方面。 <ol><li>选择该患者将接受DBS治疗。请问如果DBS-病人符合该研究的纳入标准。如果是的话，获得患者和/或伦理委员会（如适用）签署知情同意书，进行相应的认知范式手术后?...

相反，非侵入​​性的脑记录技术，如头皮脑电图和MEG，建议结合侵入性和非侵入性的神经电生理记录框架提供了一个很好的机会，相对于提取皮层和皮层下区域的信息认知情感的任务。这些信息是通过在多个频段和有关不同层次的组织对大脑功能的大脑44振荡的活动反映出来。脑振荡模式，在我们的记录框架相关的包括：皮质下振荡活动（个LFP），改变皮层，皮层下的一致性表明线性相...

在人类入侵神经生理学记录可以追溯到开创性研究癫痫手术和肿瘤研究1时从目标皮质区electrocorticographic录音和小脑。一个关键的里程碑，为这样的记录程序的进一步发展，已引进立体定向技术，提供安全，高效的进入人脑2深层结构。除了临床治疗中，在人脑侵入方法提供一个相当独特的机会来研究脑功能相对于由外部刺激，在接受深部脑刺激患者内和手术后侵入录音特别的情况下调制的记录活动模式（DBS ）程序。 DBS的适用性和有用性在各种神经和神经精神性疾病得到解决帕金森氏病（PD）到强迫症（OCD）或类似CHRO条件意识（DOC）的NIC障碍。 特别是，DBS已在帕金森氏病3,4,5，特发性震颤6，初级/广义节段性张力障碍7,8,9，亨廷顿病10,11，难治性抑郁12,13，烟碱的治疗应用和酒精成瘾14，阿尔茨海默氏病15,16，抽动秽语综合征17和意识（DOC）的慢性疾病18,19,20。 在神经精神病的范围，DBS是强迫症（OCD）针对内囊（ALIC）的前肢已批准/ CE标志的处理和正在使用针对腹舱/腹侧纹状体/腹尾（VC / VS），伏隔核（NAC）和丘脑底核（STN）21。关于强迫症22 DBS，最近的研究强调STN的作用下转化成强迫性检查机制通过利用存储为基础的范例23,24,25 ING。 范式认知和情感内涵的影响下，大脑的活动值得注意的是，调制一直强调DOC 26,27,28,29。因此，DBS被突出显示不仅作为潜在治疗慢性DOC，而且作为由记录从中央丘脑区域内和后局部场电位（LFP）打开了研究皮层下活性的调节的可能性临床过程操作性。 在DBS，电极神经外科植入是基于立体定向技术，安全地占脑解剖限制，而病人的刺激是通过手术中的脉冲刺激测试定制。手术后的LFP记录DBS电极的最初植入之后和脉冲发生器的内化之前是可能的。特别是，本协议是centereD于手术后的录音。 在同个LFP组合，皮层大脑活动的同时记录可以例如通过非侵入性的脑电图（EEG）或脑磁图（MEG）30,31来实现的。这两个非侵入性方法，由于其优异的时间分辨率的支持。而MEG比脑电图影响较小由头骨效果32，脑电图，因为它较少受引起金属植入物和头部运动伪影的影响，它可以在患者的床边33被用于显示是有利的。通过响应于施加的情绪-认知范式皮质-皮层下大脑活动（LFP和脑电图/ MEG）的同时进行记录，可以时间-频率耦合的基础上建立脑振荡和行为之间的不同关系的分析34。反过来，这种模式可能会导致患者的个性化认知的潜在生物标志物和情感状态和邻考虑的个性化设置治疗参数ptimization。 下面的协议目标侵入性和非侵入性的神经电生理记录在人类的认知和情感功能的评估，特别是在皮层和皮层下水平（EEG和个LFP）。 首先，在视频，伴随本协议中所示的神经生理记录步骤，对应于记录与执行所谓侧卫任务运动障碍（实施例1）的例子的病人。 第二，在协议中的步骤是通过着眼于从已发布的DBS例如慢性DOC 26采取分析和样品的结果（实施例2）的方法进行讨论。 这两个例子突出了提出的协议，以DBS治疗的患者具有不同的疾病和各种实验范式的适用性。

<table border="1" fo:keep-together.within-page="1" fo:keep-with-next.within-page="always">
	<tbody>
		<tr >
			<td >BrainAmp Amplifier</td>
			<td >Brain Products GmbH, Gilching Germany</td>
			<td ></td>
			<td >Quantity: 2</td>
		</tr>
		<tr >
			<td >BrainVision Recorder Software</td>
			<td >Brain Products GmbH, Gilching Germany</td>
			<td ></td>
			<td >1 License&#160;</td>
		</tr>
		<tr >
			<td >BrainVision Analyzer Software&#160;</td>
			<td >Brain Products GmbH, Gilching Germany</td>
			<td></td>
			<td >1 License&#160;</td>
		</tr>
		<tr >
			<td >Fiber Optic cables and USB connectors</td>
			<td >Brain Products GmbH, Gilching Germany</td>
			<td ></td>
			<td >These come with the above listed equipment</td>
		</tr>
		<tr >
			<td >Electrode Input box (64 channels)</td>
			<td >Brain Products GmbH, Gilching Germany</td>
			<td></td>
			<td >Quantity: 1</td>
		</tr>
		<tr >
			<td >EEG gel&#160;</td>
			<td >Natus Inc</td>
			<td></td>
			<td >Quantity: 1</td>
		</tr>
		<tr >
			<td >Isopropyl alcohol</td>
			<td>Sch&#252;lke &#38; Mayr GmbH, Germany</td>
			<td></td>
			<td >Quantity: 1</td>
		</tr>
		<tr >
			<td >Skin preparation gel</td>
			<td >Weaver and Co, USA</td>
			<td></td>
			<td >Quantity: 1</td>
		</tr>
		<tr >
			<td >MATLAB&#160;&#160;</td>
			<td>Math-Works, Natick, Massachusetts, USA</td>
			<td></td>
			<td >1 License</td>
		</tr>
		<tr >
			<td >FieldTrip toolbox</td>
			<td>http://www.fieldtriptoolbox.org/</td>
			<td></td>
			<td>Open Source</td>
		</tr>
		<tr >
			<td >INOMED MER system&#160;</td>
			<td>INOMED Corp., Emmendingen, Germany</td>
			<td></td>
			<td>Quantity: 1</td>
		</tr>
		<tr >
			<td >Macroelectrodes (model 3387 quadripolar DBS lead)</td>
			<td>Medtronic Inc., Minneapolis, MN, USA</td>
			<td></td>
			<td>Quantity: 2</td>
		</tr>
		<tr >
			<td >Sterile percutaneous extension wires (model 3550-05)&#160;</td>
			<td>Medtronic Inc., Minneapolis, MN, USA</td>
			<td></td>
			<td>Quantity: 2</td>
		</tr>
		<tr >
			<td >Twist lock cable (model 3550-03)&#160;</td>
			<td>Medtronic Inc., Minneapolis, MN, USA</td>
			<td></td>
			<td>Quantity: 2</td>
		</tr>
		<tr >
			<td >custom made connectors to DIN 428092 touch proof connectors</td>
			<td></td>
			<td></td>
			<td>Quantity: 2</td>
		</tr>
		<tr >
			<td >Vercise Lead kit DB -2201&#160;</td>
			<td>Boston Scientific</td>
			<td></td>
			<td>Quantity: 2</td>
		</tr>
		<tr >
			<td >Contact extenion kit NM-3138&#160;</td>
			<td>Boston Scientific</td>
			<td></td>
			<td>Quantity: 2</td>
		</tr>
		<tr >
			<td >O.R. cabel &#38; extension SC-4100 A&#160;</td>
			<td>Boston Scientific</td>
			<td></td>
			<td>Quantity: 2</td>
		</tr>
		<tr >
			<td >connector &#160; to touch proof&#160;</td>
			<td>Twente Medical Systems International B.V.</td>
			<td></td>
			<td>Quantity: 2</td>
		</tr>
		<tr >
			<td >CT scanner Modell PQ2000 (Postoperative CT scans)</td>
			<td>Philips Healthcare GmbH Hamburg</td>
			<td></td>
			<td>Quantity: 1</td>
		</tr>
		<tr >
			<td >Presentation Software (Flanker Task)</td>
			<td>Neurobehavioral systems Inc.</td>
			<td></td>
			<td>1 License&#160;</td>
		</tr>
		<tr >
			<td >MEG System</td>
			<td>Elekta Neuromag Inc</td>
			<td></td>
			<td>Alternatively</td>
		</tr>
		<tr >
			<td >High-density EEG sensor net (128 or 256 channels)</td>
			<td>Electrical Geodesics Inc (EGI), USA</td>
			<td></td>
			<td>Alternatively</td>
		</tr>
	</tbody>
</table>

combined invasive subcortical and non-invasive surface neurophysiological recordings for the assessment of cognitive and emotional functions in humans

尽管在用于提取关于人类大脑的机理的关键信息将非侵入性的脑电图（EEG），磁 - 脑照相（MEG）和功能性磁共振成像（fMRI）成功的，这些方法仍不足以提供关于生理信息流程体现在皮层下水平的认知和情感功能。在这方面，在人类现代侵袭性临床方法，如脑深部刺激（DBS），提供了巨大的可能性来记录皮层大脑活动，即局部场电位（个LFP）表示从局部基底节或丘脑区域的神经组件相干活性。尽管事实上在人类侵入方法被医疗指示之后才施加，因而记录的数据对应于改变的脑回路，宝贵的见解可以关于完整的脑功能的关系存在于脑振荡来获得活动和病症的响应于实验认知范式病理生理学。在这个方向上，在患者的帕金森氏病（PD），越来越多的DBS研究的目标不仅运动功能，而且更高级别进程，如情绪，决策，注意力，记忆和感官知觉。最近的临床试验还强调DBS的作用，在神经精神障碍，从强迫症（OCD）意识（DOC）的慢性疾病的替代疗法。因此，我们专注于采用联合微创（LFP）和非侵入性（EEG）人脑的录音在评估认知和情感处理槽实验范式的皮质，皮质下结构的作用（ 如语音刺激与情感内涵或范式认知控制，如侧卫任务），对接受DBS治疗的患者。

对于DBS-DOC情况下（例2），我们现在提供目标定位为DBS植入数据，LFP电极和脑电图的示意图设立，脑电图和LFP活动（原始数据）和有代表性的分析结果的示范录音： 图2A示出了投射在解剖图谱36计划轨迹（黑线），第30，冠状动脉，前连合（AC）（红线：AC-PC平面）后面10.7毫米。红色圆圈大关针对性的最低15...

Watch this Scientific Journal Video about Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans at JoVE

Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans (Video) | JoVE

The present protocol aims at assessing cognitive-emotional functions in the basal ganglia by simultaneous neurophysiological recording of local field potentials and non-invasive brain cortical activity (EEG). The procedure is exemplified by the use of paradigms involving speech stimuli with emotional connotation or the Flanker task involving cognitive control.

在人类联合微创皮层下和非侵入性的表面神经生理学录音认知的评估和情感作用

In spite of the success in applying non-invasive electroencephalography (EEG), magneto-encephalography (MEG) and functional magnetic resonance imaging ...

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Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans

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同时头皮脑电图（EEG），肌电图（EMG）和全身分部惯性录制多模态神经解码

Recent  studies support the involvement of supraspinal networks in control of bipedal  human walking. Part of this evidence  encompasses studies, ...

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