Name: combining multiple data acquisition systems to study corticospinal output and multi-segment biomechanics
Uploaded: 2016-01-09T13:00:01
Description: Watch this Scientific Journal Video about Combining Multiple Data Acquisition Systems to Study Corticospinal Output and Multi-segment Biomechanics at JoVE.com

The authors thank funding from the Natural Sciences and Engineering Research Council to AJN.

BEMÆRK: Følgende protokol kan anvendes til en række eksperimenter. Nedenfor er oplysninger om et eksperiment, der involverer en visuelt guidet arm nå opgave til en af ​​seks rumlige mål, der vises på en computerskærm. TMS, at sonde corticospinal uro, er udløst af enten analoge signaler fra bevægelsen (dvs. EMG eller electrogoniometer input) eller digitale signaler genereret fra sweep-baserede datafangst software. Denne undersøgelse blev godkendt af McMaster Research Ethics Board i overensstemmelse...

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The present manuscript details an innovative method to integrate TMS and motion capture systems in the context of a visuo-motor task. To make rapid and meaningful advances in the study of human motor control, it is essential that methodologies allow for precise communication across multiple hardware and software systems. The paradigm presented could be used to study a variety of research interests including the cortical contribution to motor learning, the neurophysiology of motor control, and multi-joint movement contr...

Transkraniel magnetisk stimulation (TMS) er en ikke-invasiv metode til at stimulere humane cortex. 3,5 Der er flere TMS protokoller, der bruges til at forstå kortikal funktion, såsom enkelt- og multiple pulser, dual-site stimulation til at probe funktionelt tilslutning, og repetitive impulser til fremme af neural plasticitet. 4,6-8 TMS protokoller kan også kombineres for at fremme den nuværende forståelse af de menneskelige kortikale processer og vejlede neurale rehabiliteringsstrategier. Ud over at stimulere cortex, kan TMS også anvendes til at forstå sub-cortical funktion ved stimulering af corticospinal tarmkanalen eller cerebellum. En af de største tekniske udfordringer øjeblikket står TMS forskning er muligheden for at undersøge den rolle af kortikale områder i målrettet frivillige bevægelser hos mennesker. Flere overvejelser bidrager til denne tekniske udfordring. For det første bør TMS levering kombineres med tidstro menneskelig bevægelse capture. På denne måde kan TMS impulser leveres eller udløst af funktioner i en bevægelse sekvens, der tilvejebringer en tid-låst tilgang til at studere komplekse bevægelser. For det andet, integrerer TMS levering og motion capture tillader en detaljeret karakterisering af komplekse bevægelser, som det udfolder sig, hvilket vil fremme forståelsen af ​​hjernen-adfærd relationer, der ligger til grund for motorstyring. På nuværende tidspunkt er der ingen kommercielt tilgængelige systemer, inklusiv integrerer TMS og motion capture metoder. For neuroforskere inden for motorstyring, dette tomrum typisk udmønter sig i tidskrævende, tekniske udfordringer for at integrere flere erhvervelse og levering af data software og hardware-systemer. Denne tekniske begrænsning har også resulteret i sparsomme forskning dedikeret til studiet af dynamiske flere fælles bevægelser involverer overekstremiteterne. For TMS at fremme inden for human motorstyring, er det bydende nødvendigt, at kortikal funktion probes under komplekse menneskelig bevægelse. <p class = &quot;jove_content&quot;&gt; For effektivt at integrere TMS og motion capture metoder, erhvervelsen Systemet skal gøre det muligt i realtid samtidig TMS og motion capture. For det andet skal systemet være egnet til at studere bevægelse kinematik (dvs.., Beskrivelse af bevægelsen), bevægelse kinetik (dvs.., Tvinger det forårsager bevægelse), og muskel aktivitet. For det tredje, skal systemet være i stand til at synkronisere TMS pulser til disse bevægelser funktioner, og udløses af kriterier baseret på komplekse bevægelse funktioner. Et sådant system vil give et væsentligt sammenhæng mellem kortikal funktion og kinematisk og kinetik bevægelse. Dette håndskrift detaljer en unik tilgang til at integrere metoder til TMS og motion capture. Denne fremgangsmåde giver mulighed for detaljeret analyse af mekanikken i komplekse multi-joint bevægelser, og tillader automatiseret styring af TMS pulser udløst af særlige træk ved bevægelsen (dvs. kinematik, kinetik, eller muskel aktivitet). Endvidere disse data ACQuisition systemet giver mulighed for TMS og motion capture til at blive integreret med eksperimentelle paradigmer, der kræver visuo-motoriske eller sensomotoriske opgaver. Dette manuskript detaljer en innovativ tilgang til at integrere almindeligt brugte motion capture hardware og software systemer med henblik på at kombinere TMS og erhvervelse menneskelig bevægelse og analyse. Data præsenteres ved hjælp af en stikprøve undersøgelse af menneskets kortikal funktion under plane flere fælles bevægelse. Den software scripts, der er nødvendige for at udføre eksperimentet er tilgængelige for download.

<table border="0" cellpadding="0" cellspacing="0" width="626">
	<tbody>
		<tr height="21">
			<td height="21" style="height:21px;width:216px;">Polhemus FASTRAK</td>
			<td style="width:124px;">Polhemus Inc.</td>
			<td style="width:119px;"></td>
			<td style="width:167px;">6 degrees of freedom electromagnetic motion tracking device with 4 sensors</td>
		</tr>
		<tr height="42">
			<td height="42" style="height:42px;width:216px;">Presentation</td>
			<td style="width:124px;">Neurobehavioural Systems Inc.</td>
			<td style="width:119px;"></td>
			<td>A fully programmable software for experiments involving data acquisition and stimulus delivery</td>
		</tr>
		<tr height="63">
			<td height="63" style="height:63px;width:216px;">Cutom built Exoskeleton</td>
			<td style="width:124px;">80/20 Inc. - The industrial erector set</td>
			<td style="width:119px;">Varies</td>
			<td>Various parts used to build the exoskeleton</td>
		</tr>
		<tr height="42">
			<td height="42" style="height:42px;width:216px;">Brainsight</td>
			<td style="width:124px;">Rogue Research Inc.</td>
			<td style="width:119px;"></td>
			<td>Neuronavigation software to track coil position throughout the experiment</td>
		</tr>
	</tbody>
</table>

combining multiple data acquisition systems to study corticospinal output and multi-segment biomechanics

Transcranial magnetic stimulation techniques allow for an in-depth investigation into the neural mechanisms that underpin human behavior. To date, the use of TMS to study human movement, has been limited by the challenges related to precisely timing the delivery of TMS to features of the unfolding movement and, also, by accurately characterizing kinematics and kinetics. To overcome these technical challenges, TMS delivery and acquisition systems should be integrated with an online motion tracking system. The present manuscript details technical innovations that integrate multiple acquisition systems to facilitate and advance the use of TMS to study human movement. Using commercially available software and hardware systems, a step-by-step approach to both the hardware assembly and the software scripts necessary to perform TMS studies triggered by specific features of a movement is provided. The approach is focused on the study of upper limb, planar, multi-joint reaching movements. However, the same integrative system is amenable to a multitude of sophisticated studies of human motor control.

Figur 3 viser resultaterne fra en enkelt forsøg. I dette forsøg figur 3A viser den oprindelige placering af deltageren, og efter en auditiv &quot;Book&quot; cue, deltageren flyttede så hurtigt og præcist som muligt til målet (dvs.., Den endelige position). Sweep-baserede datafangst software udløste en TMS puls baseret på EMG debut i biceps brachii musklen. Dette tillod mål for corticospinal output rettet til øvre armmuskler skal evaluer...

Watch this Scientific Journal Video about Combining Multiple Data Acquisition Systems to Study Corticospinal Output and Multi-segment Biomechanics at JoVE.com

Combining Multiple Data Acquisition Systems to Study Corticospinal Output and Multi-segment Biomechanics

The use of transcranial magnetic stimulation (TMS) to study human motor control requires the integration of data acquisition systems to control TMS delivery and simultaneously record human behavior. The present manuscript provides a detailed methodology for integrating data acquisition systems for the purpose of investigating human movement via TMS.

Ved at kombinere flere data Acquisition Systems til at studere corticospinal udgang og Multi-segment Biomekanik

Transcranial magnetic stimulation techniques allow for an in-depth investigation into the neural mechanisms that underpin human behavior. To date, the use ...

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