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DOI :
10.3791/53746-v
•
9:26 min
May 16th, 2016
Chapters
0:05
Title
1:07
Intra-articular Injection of Monoiodoacetate (MIA) in the Knee
3:57
Measurement of Mechanical Hypersensitivity (Allodynia)
6:00
Measurement of Weight Bearing Deficit
7:29
Results: Behavioral Changes after MIA Injection
8:22
Conclusion
変形性関節症(OA)、または変性関節疾患、部分的にしか利用でき鎮痛剤によって制御されたまま痛みを伴う衰弱状態です。動物モデルは、OAに関連する疼痛の機序の我々の理解を改善するために開発されています。ここでは、マウスでのOA痛みのmonoiodoacetateモデルのための方法論について説明します。
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