Metoder for å finne alternative Arrangøren Bruk og transkripsjonsregulering av Murine Bcrp1
May 27th, 2016
•Karthika Natarajan1,2, Yi Xie1,3, Takeo Nakanishi4, Rebecca S. Moreci5,6, Pancharatnam Jeyasuria7, Arif Hussain1,3,8,9, Douglas D. Ross1,3,8,9,10,11
1Greenebaum Cancer Center, University of Maryland School of Medicine, 2Pharmaceutical Sciences, University of Maryland School of Pharmacy, 3Baltimore VA Medical Center, 4Membrane Transport and Biopharmaceutics, School of Pharmaceutical Sciences, Kanazawa University, 5Obstetrics, Gynecology and Reproductive Science, University of Pittsburgh, 6Magee Women's Research Institute, 7Obstetrics, Gynecology, Perinatal Research Branch (NICHD), Wayne State University School of Medicine, 8Medicine, University of Maryland School of Medicine, 9Pathology, University of Maryland School of Medicine, 10Pharmacology, University of Maryland School of Medicine, 11Experimental Therapeutics, University of Maryland School of Medicine
Med den murine ABC-transportør Bcrp1 (ABCG2) som et eksempel, i-silico-protokoller er presentert for å detektere alternativ promoter bruk i gener som blir uttrykt i musevev, og for å evaluere funksjonaliteten av de alternative promotorer som er identifisert ved hjelp av rapportør analyser.
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