헤파린 결합 도메인 골 형성 성장 인자 전달을위한 고분자 전해질 복합
August 22nd, 2016
•Raymond Wing Moon Lam1, Sunny Akogwu Abbah2, Wang Ming1, Mathanapriya Naidu1, Felly Ng1, Hu Tao1, James Goh Cho Hong3,4, Kang Ting5, Wong Hee Kit1,4
1Department of Orthopaedic Surgery, Yong Loo Lin School of Medicine, National University of Singapore, 2Centre for Research in Medical Devices (CÚRAM), National University of Ireland Galway, 3Department of Bioengineering, Faculty of Engineering, National University of Singapore, 4Tissue Engineering Program, National University of Singapore, 5Department of Orthopaedic Surgery and the Orthopaedic Hospital Research Center, University of California, Los Angeles
Self-assembled polyelectrolyte complexes (PEC) fabricated from heparin and protamine were deposited on alginate beads to entrap and regulate the release of osteogenic growth factors. This delivery strategy enables a 20-fold reduction of BMP-2 dose in spinal fusion applications. This article illustrates the benefits and fabrication of PECs.
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