Name: eye-tracking control to assess cognitive functions in patients with amyotrophic lateral sclerosis
Uploaded: 2016-10-13T15:00:00
Description: Watch this Scientific Journal Video about Eye-Tracking Control to Assess Cognitive Functions in Patients with Amyotrophic Lateral Sclerosis at JoVE.com

笔者想感谢拉尔夫Kuhne公司的技术支持。这项工作是由德意志研究联合会（DFG）和德国联邦联邦教育与研究部（BMBF＃01GM1103A）的资助。这是一个欧盟联合规划署，神经退行性疾病研究（JPND）项目。该项目是通过JPND- 例如 ，德国，德国联邦联邦教育与研究部（BMBF，FKZ），瑞典，VetenskaprådetSVERIGE，波兰，Narodowe中枢巴丹我Rozwoju（NCBR）的支持下，下面的组织的支持。

该研究经乌尔姆大学（声明第19/12）的伦理委员会和协议描述如下，因此他们的指导方针。所有参与者都签署了知情同意书。 1.刺激和测试环境<ol><li>为了保持分心到最低限度执行在黑暗或非常昏暗，安静的房间研究。 </li><li>使用适当的眼跟踪装置。 注：有多种可用来进行眼动研究设备。在本研究使用了与护目镜的便携式眼球运动记录装置，它同步地测量双眼眼的位置...

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这是一个具有挑战性的任务成功评估患者的认知状态与ALS谁不能说和写。使用videooculography系统提供了一个有前途的方法。兹介绍技术在检测的认知缺陷，从而起到照顾者的负担和疾病管理20 ALS患者的背景下举足轻重的作用可靠。此外，CPM和D2的测试的动眼神经版本各自标准纸铅笔版本显著相关，但需要对权利要求的临床环境的有用的进一步支持。 研究者需要确保眼球...

肌萎缩性侧索硬化症（ALS）是一种致命的神经变性疾病通常是导致死亡在3至5年。在病理学的过程中，本与在运动能力1呼吸和延髓运作以及损伤的渐进性丧失的患者。这股与额颞叶痴呆2一些临床，病理学和遗传特征，它是有据可查的ALS患者的约30％显示出认知缺陷3。这些赤字是在执行功能，言语流畅性和语言的4域最突出和对生存的5，6合规性和照顾者的负担7的影响。因此，可靠的神经心理学评估是本病的关键。 在电机和语音能力前进损伤，然而，对于在疾病8的后期阶段的认知能力的全面评估的限制因素。她的即，基于动眼神经方法似乎是非常有前途的，因为基本的眼动控制保持不变为ALS，为广大患者9的过程中，一个同等长的时间。眼睛跟踪参数本身已被用来获得关于患者的认知状态的ALS 10信息，并还与ALS 11的顺序扩频模式相关。眼球运动，以控制认知测试中的ALS的上下文中的装置也已研究了以往的作品。使用的动眼神经基于版本的一项研究已经成功地证明了其易用性健康对照者的足迹，测验12，而另一个发现合适的基于认知能力和健康对照和ALS患者之间的区分认知越来越少受损患者区分13。 这里所描述的研究使用基于眼球运动的方法来研究AL认知障碍病患者，特别是在执行功能的领域。两个很好的验证和常用的神经心理测验进行了调整，以眼动控制：乌鸦的彩色渐进矩阵（CPM）14和D2测试15。该CPM是用来衡量行政机关和视觉空间能力以及流体智力非语言手段。的D2-测试也是用于揭示在选择性和持续的注意力和可视处理速度的域执行功能障碍的非口头的工具。两个广泛用于已在以往的研究评估疾病16和ALS患者的神经心理状态相比健康对照17的过程中潜在的认知衰退已成功地用于临床工具。 这项工作的目的是展示使用REL在ALS独立运动和语言障碍的认知缺陷的成功评估的要求iable，眼睛跟踪基础版的CPM和D2-测试。重要的是，这里所描述的方法有可能使被扩展研究的重症患者运动障碍等的人群。

<table border="0" cellpadding="0" cellspacing="0" width="1081">
	<tbody>
		<tr height="21">
			<td>EyeSeeCam</td>
			<td>EyeSeeTec GmbH; 82256 F&#252;rstenfeldbruck, Germany</td>
			<td></td>
			<td>Videooculography device</td>
		</tr>
	</tbody>
</table>

eye-tracking control to assess cognitive functions in patients with amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with pathological involvement of upper and lower motoneurons, subsequently leading to progressive loss of motor and speech abilities. In addition, cognitive functions are impaired in a subset of patients. To evaluate these potential deficits in severely physically impaired ALS patients, eye-tracking is a promising means to conduct cognitive tests. The present article focuses on how eye movements, an indirect means of communication for physically disabled patients, can be utilized to allow for detailed neuropsychological assessment. The requirements, in terms of oculomotor parameters that have to be met for sufficient eye-tracking in ALS patients are presented. The properties of stimuli, including type of neuropsychological tests and style of presentation, best suited to successfully assess cognitive functioning, are also described. Furthermore, recommendations regarding procedural requirements are provided. Overall, this methodology provides a reliable, easy to administer and fast approach for assessing cognitive deficits in patients who are unable to speak or write such as patients with severe ALS. The only confounding factor might be deficits in voluntary eye movement control in a subset of ALS patients.

对于这里介绍的研究的目的即一个可靠的动眼神经基于神经心理学评估ALS患者，内部开发的软件商店中拍摄对象的一个单独的文件中CPM的选择，允许对正确的百分比人工计算的发展答案。为D2-试验，垂直眼球运动的记录用的+ 5°的阈值用于检测相关响应的手动分析。录音分配给每个刺激呈现和正确答案的百分比可以随后进行计算。有可用的数据是如何被分析的许多?...

Watch this Scientific Journal Video about Eye-Tracking Control to Assess Cognitive Functions in Patients with Amyotrophic Lateral Sclerosis at JoVE.com

Eye-Tracking Control to Assess Cognitive Functions in Patients with Amyotrophic Lateral Sclerosis

Cognitive deficits are common in about one third of patients with amyotrophic lateral sclerosis, a neurological condition leading to progressive impairments in speech and movement abilities. To conduct cognitive tests in patients unable to speak or write a reliable and easy to administer eye-tracking paradigm was developed.

眼跟踪控制，以评估患者的认知功能与肌萎缩性脊髓侧索硬化症

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with pathological involvement of upper and lower motoneurons, subsequently leading to ...

Research

JoVE Journal

Behavior

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

与年龄相关的变化认知功能使用EmoCogMeter，新型平板计算机基础法评估

The main goal of this study was to assess the usability of a tablet-computer-based application (EmoCogMeter) in investigating the effects of age on ...

科研

行为学

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

针对调查中的认知控制网络与关联维度变化卡片分类性能的功能连通性年龄相关性差异的方法

The ability to adjust behavior to sudden changes in the environment develops gradually in childhood and adolescence. For example, in the Dimensional ...

Uncovering Beat Deafness: Detecting Rhythm Disorders with Synchronized Finger Tapping and Perceptual Timing Tasks

A set of behavioral tasks for assessing perceptual and sensorimotor timing abilities in the general population (i.e., non-musicians) is presented here ...

Recording Mouse Ultrasonic Vocalizations to Evaluate Social Communication

录制鼠标超声波发声评价社会交往

Mice emit ultrasonic vocalizations in different contexts throughout development and in adulthood. These vocal signals are now currently used as proxies ...

A Method to Quantify Visual Information Processing in Children Using Eye Tracking

一种方法来量化视觉信息加工儿童使用眼动追踪

Visual problems that occur early in life can have major impact on a child's development. Without verbal communication and only based on observational ...

Eye Tracking During Visually Situated Language Comprehension: Flexibility and Limitations in Uncovering Visual Context Effects

视觉语言理解中的眼动追踪: 发现视觉语境效果的灵活性和局限性

The present work is a description and an assessment of a methodology designed to quantify different aspects of the interaction between language processing ...

Comparing Eye-tracking Data of Children with High-functioning ASD, Comorbid ADHD, and of a Control Watching Social Videos

患有高功能性泛型疾病、无注意力缺陷多动障碍和控制社会视频的儿童眼动追踪数据比较

Children with autism spectrum disorders (ASD) are known to have sensory-perceptual processing deficits that weaken their abilities to attend and perceive ...

Simultaneous Eye Tracking and Single-Neuron Recordings in Human Epilepsy Patients

人类癫痫患者同步眼动追踪和单神经记录

Intracranial recordings from patients with intractable epilepsy provide a unique opportunity to study the activity of individual human neurons during ...

Investigating the Deployment of Visual Attention Before Accurate and Averaging Saccades via Eye Tracking and Assessment of Visual Sensitivity

通过视觉跟踪和视觉灵敏度评估, 探讨准确、平均的视频前视觉注意的部署

This experimental protocol was designed to investigate whether visual attention is obligatorily deployed at the endpoint of saccades. To this end, we ...

Defining the Role Of Language in Infants' Object Categorization with Eye-tracking Paradigms

用眼动跟踪范式界定语言在婴儿对象分类中的作用

Assessing infant category learning is a challenging but vital aspect of studying infant cognition. By employing a familiarization-test paradigm, we ...