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פלטפורמה של מבחנים אנטי biofilm המתאים לחקירת ספריות תרכובת טבעיות

DOI :

10.3791/54829-v

December 27th, 2016

December 27th, 2016

16,900 Views

1Pharmaceutical Design and Discovery (PharmDD), Faculty of Pharmacy, University of Helsinki

Biofilm infections show high tolerance towards chemotherapy. No single assay captures the complexity of biofilms. Instead, complementary assays are needed. We present a screening platform (developed for S. aureus) that combines assays for viability, biomass, and biofilm matrix. It allows anti-biofilm drug discovery, including the assessment of long-term chemotherapeutic effects.

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