Name: palladium n-heterocyclic carbene complexes: synthesis from benzimidazolium salts and catalytic activity in carbon-carbon bond-forming reactions
Uploaded: 2017-07-30T14:00:00
Description: Watch this Scientific Journal Video about Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions at JoVE.com

我们承认药学院（悉尼大学），Erciyes大学研究基金和TUBITAK（1059B141400496）的财务支持。我们感谢Tim Harland（悉尼大学）编辑视频。

注意：使用许多挥发性溶剂作为下面详述的方案的一部分，以便在工作通风橱中进行所有实验。在使用前请穿戴适当的个人防护装备，并咨询各试剂的MSDS;在此提供有关危险试剂和步骤的简要信息。 苯并咪唑盐的合成和纯化（化合物1-4） <ol><li>立即将100mL Schlenk管夹紧，并将搅拌棒，1mmol苯并咪唑，1mmol氢氧化钾和60mL乙醇作为溶剂。 注意：氢氧...

<ol>
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Chem. 66 (8), 1396-1404 (2013).</li><li>Aktas, A., Akkoc, S., Gok, Y. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Palladium+catalyzed+Mizoroki-Heck+and+Suzuki-Miyaura+reactions+using+naphthalenomethyl-substituted+imidazolidin-2-ylidene+ligands+in+aqueous+media.">Palladium catalyzed Mizoroki-Heck and Suzuki-Miyaura reactions using naphthalenomethyl-substituted imidazolidin-2-ylidene ligands in aqueous media.</a> J. Coord. Chem. 66 (16), 2901-2909 (2013).</li><li>Cetinkaya, B., Alici, B., Ozdemir, I., Bruneau, C., Dixneuf, P. H. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=2-imidazoline+and+1,4,5,6-tetrahydropyrimidine-ruthenium(II)+complexes+and+catalytic+synthesis+of+furan.">2-imidazoline and 1,4,5,6-tetrahydropyrimidine-ruthenium(II) complexes and catalytic synthesis of furan.</a> J. Organomet. 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B. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Zinc+N-heterocyclic+carbene+complexes+and+their+polymerization+of+D,L-lactide.">Zinc N-heterocyclic carbene complexes and their polymerization of D,L-lactide.</a> J. Organomet. Chem. 690 (24-25), 5881-5891 (2005).</li><li>Lai, Y. B., Lee, C. S., Lin, W. J., Naziruddin, A. R., Hwang, W. S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Bis-chelate+N-heterocyclic+tetracarbene+Ru(II)+complexes:+Synthesis,+structure,+and+catalytic+activity+toward+transfer+hydrogenation+of+ketones.">Bis-chelate N-heterocyclic tetracarbene Ru(II) complexes: Synthesis, structure, and catalytic activity toward transfer hydrogenation of ketones.</a> Polyhedron. 53, 243-248 (2013).</li><li>Savka, R. D., Plenio, H. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=A+hexahydro-s-indacene+based+NHC+ligand+for+olefin+metathesis+catalysts.">A hexahydro-s-indacene based NHC ligand for olefin metathesis catalysts.</a> J. Organomet. Chem. 710, 68-74 (2012).</li><li>Yigit, M., Yigit, B., Gok, Y. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Synthesis+of+novel+palladium(II)+N-heterocyclic+carbene+complexes+and+their+catalytic+activities+in+the+direct+C5+arylation+reactions.">Synthesis of novel palladium(II) N-heterocyclic carbene complexes and their catalytic activities in the direct C5 arylation reactions.</a> Inorg. Chim. Acta. 453, 23-28 (2016).</li><li>Yasar, S., Sahin, C., Arslan, M., Ozdemir, I. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Synthesis,+characterization+and+the+Suzuki-Miyaura+coupling+reactions+of+N-heterocyclic+carbene-Pd(II)-pyridine+(PEPPSI)+complexes.">Synthesis, characterization and the Suzuki-Miyaura coupling reactions of N-heterocyclic carbene-Pd(II)-pyridine (PEPPSI) complexes.</a> J. Organomet. Chem. 776, 107-112 (2015).</li><li>Ozdemir, I., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=N-Heterocyclic+carbenes:+Useful+ligands+for+the+palladium-catalysed+direct+C5+arylation+of+heteroaromatics+with+aryl+bromides+or+electron-deficient+aryl+chlorides.">N-Heterocyclic carbenes: Useful ligands for the palladium-catalysed direct C5 arylation of heteroaromatics with aryl bromides or electron-deficient aryl chlorides.</a> Eur. J. Inorg. Chem. 12 (12), 1798-1805 (2010).</li><li>Clavier, H., Nolan, S. P. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=N-heterocyclic+carbene+and+phosphine+ruthenium+indenylidene+precatalysts:+A+comparative+study+in+Olefin+metathesis.">N-heterocyclic carbene and phosphine ruthenium indenylidene precatalysts: A comparative study in Olefin metathesis.</a> Chem. Eur. J. 13 (28), 8029-8036 (2007).</li><li>Johnson, J. S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Catalyzed+reactions+of+acyl+anion+equivalents.">Catalyzed reactions of acyl anion equivalents.</a> Angew. Chem. Int. Ed. 43 (11), 1326-1328 (2004).</li><li>Marion, N., Diez-Gonzalez, S., Nolan, S. P. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=N-heterocyclic+carbenes+as+organocatalysts.">N-heterocyclic carbenes as organocatalysts.</a> Angew. Chem. Int. Ed. 46 (17), 2988-3000 (2007).</li><li>Perry, M. C., Burgess, K. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Chiral+N-heterocyclic+carbene-transition+metal+complexes+in+asymmetric+catalysis.">Chiral N-heterocyclic carbene-transition metal complexes in asymmetric catalysis.</a> Tetrahedron: Asymmetry. 14 (8), 951-961 (2003).</li><li>Zeitler, K. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Extending+mechanistic+routes+in+heterazolium+catalysis-promising+concepts+for+versatile+synthetic+methods.">Extending mechanistic routes in heterazolium catalysis-promising concepts for versatile synthetic methods.</a> Angew. Chem. Int. Ed. 44 (46), 7506-7510 (2005).</li><li>Schwarz, J., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=N-Heterocyclic+carbenes,+part+25+-+Polymer-supported+carbene+complexes+of+palladium:+Well-defined,+air-stable,+recyclable+catalysts+for+the+Heck+reaction.">N-Heterocyclic carbenes, part 25 - Polymer-supported carbene complexes of palladium: Well-defined, air-stable, recyclable catalysts for the Heck reaction.</a> Chem. Eur. J. 6 (10), 1773-1780 (2000).</li><li>Akkoc, S., Gok, Y., Ilhan, I. O., Kayser, V. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=N-Methylphthalimide-substituted+benzimidazolium+salts+and+PEPPSI+Pd-NHC+complexes:+synthesis,+characterization+and+catalytic+activity+in+carbon-carbon+bond-forming+reactions.">N-Methylphthalimide-substituted benzimidazolium salts and PEPPSI Pd-NHC complexes: synthesis, characterization and catalytic activity in carbon-carbon bond-forming reactions.</a> Beilstein J. Org. Chem. 12, 81-88 (2016).</li><li>Karaca, E. O., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Palladium+complexes+with+tetrahydropyrimidin-2-ylidene+ligands:+Catalytic+activity+for+the+direct+arylation+of+furan,+thiophene,+and+thiazole+derivatives.">Palladium complexes with tetrahydropyrimidin-2-ylidene ligands: Catalytic activity for the direct arylation of furan, thiophene, and thiazole derivatives.</a> Organometallics. 34 (11), 2487-2493 (2015).</li><li>Ozdemir, I., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=N-Heterocyclic+carbene-palladium+catalysts+for+the+direct+arylation+of+pyrrole+derivatives+with+aryl+chlorides.">N-Heterocyclic carbene-palladium catalysts for the direct arylation of pyrrole derivatives with aryl chlorides.</a> Beilstein J. Org. Chem. 9, 303-312 (2013).</li><li>Senocak, A., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Synthesis,+crystal+structures,+magnetic+properties+and+Suzuki+and+Heck+coupling+catalytic+activities+of+new+coordination+polymers+containing+tetracyanopalladate(II)+anions.">Synthesis, crystal structures, magnetic properties and Suzuki and Heck coupling catalytic activities of new coordination polymers containing tetracyanopalladate(II) anions.</a> Polyhedron. 49 (1), 50-60 (2013).</li><li>Akkoc, S., Gok, Y. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Dichlorido(3-chloropyridine-N)+1,3-dialkylbenzimidazol-2-ylidene+palladium(II)+complexes:+Synthesis,+characterization+and+catalytic+activity+in+the+arylation+reaction.">Dichlorido(3-chloropyridine-N) 1,3-dialkylbenzimidazol-2-ylidene palladium(II) complexes: Synthesis, characterization and catalytic activity in the arylation reaction.</a> Inorg. Chim. Acta. 429, 34-38 (2015).</li><li>Akkoc, S., Gok, Y. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Catalytic+activities+in+direct+arylation+of+novel+palladium+N-heterocyclic+carbene+complexes.">Catalytic activities in direct arylation of novel palladium N-heterocyclic carbene complexes.</a> Appl. Organomet. Chem. 28 (12), 854-860 (2014).</li><li>Akkoc, S., Gok, Y., Ilhan, I. O., Kayser, V. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=In+situ+Generation+of+Efficient+Palladium+N-heterocyclic+Carbene+Catalysts+Using+Benzimidazolium+Salts+for+the+Suzuki-Miyaura+Cross-coupling+Reaction.">In situ Generation of Efficient Palladium N-heterocyclic Carbene Catalysts Using Benzimidazolium Salts for the Suzuki-Miyaura Cross-coupling Reaction.</a> Curr. Org. Synth. 13 (5), 761-766 (2016).</li></ol>

合成和纯化四种苯并咪唑鎓盐，随后他们的钯NHC络合物的方案被故意地提供给最大的细节，以帮助年轻的科学家或那些新的现场掌握他们。考虑到同样的目标，还详细介绍了在芳基化和铃木 - 宫古反应中测试四种络合物的催化活性的方案。此外，我们试图将方案呈现为尽可能一般的形式，以允许其他人容易地适应它们用于许多其它/新的钯NHC复合物的催化活性的合成，纯化和测试。 <p class="jove_c...

N-杂环碳烯（NHC）引起了极大的关注，尤其是其催化各种重要反应的能力，如复分解，呋喃的生成，聚合，氢化硅烷化，氢化，芳基化，铃木 - 宫崎交联和Mizoroki-Heck交联1，2，3，4，5，6，7，8，9，10，11。 NHC可与金属结合;这种金属- NHC络合物作为辅助配体的过渡金属催化的反应被广泛使用和有机催化剂12，13，14， </SUP&gt; 15，16。通常，由于金属 - 碳配位键17的高解离能，其对空气，水分和热量非常稳定。 这里，四个苯并咪唑盐（化合物1 - 4）先前示出的合成和纯化的协议及其钯NHC络合物（化合物5 -分别为8，）是详细18。先前使用各种技术来表征盐和络合物18 。由于用于芳基化和Suzuki-Miyaura交叉偶联反应9，10，11的催化相似的化合物，用于测试复合物的催化活性在芳基化和铃木-宫浦反应的类型，它们在还详细。重要的是，用于合成，纯化和测试复合物的催化活性的方案一般足够容易地适应新的钯NHC络合物。

<table border="1" fo:keep-together.within-page="1" fo:keep-with-next.within-page="always">
	<tbody>
		<tr>
			<td>1-chloro-4-nitrobenzene</td>
			<td>Sigma-Aldrich (Interlab A.S., USA)</td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>2,5-dimethoxyphenylboronic acid</td>
			<td>Sigma-Aldrich (Interlab A.S., USA)</td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>2-n-butylfuran</td>
			<td>Sigma-Aldrich (Interlab A.S., USA)</td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>2-n-butylthiophene</td>
			<td>Sigma-Aldrich (Interlab A.S., USA)</td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>3-chloropyridine</td>
			<td>Merck (Darmstadt, Germany)</td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>4-bromoacetophenone</td>
			<td>Merck (Darmstadt, Germany)</td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>4-bromoanisole</td>
			<td>Sigma-Aldrich (Interlab A.S., USA)</td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>4-chlorotoluene</td>
			<td>Sigma-Aldrich (Interlab A.S., USA)</td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>4-methoxy-1-chlorobenzene</td>
			<td>Merck (Darmstadt, Germany)</td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>4-tert-butylphenylboronic acid</td>
			<td>Sigma-Aldrich (Interlab A.S., USA)</td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>Benzimidazole</td>
			<td>Merck (Darmstadt, Germany)</td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>Bromobenzene</td>
			<td>Merck (Darmstadt, Germany)</td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>Celite</td>
			<td>Merck (Darmstadt, Germany)</td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>Dichloromethane</td>
			<td>Merck (Darmstadt, Germany)</td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>Diethyl ether</td>
			<td>Sigma-Aldrich (Interlab A.S., USA)</td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>Ethyl acetate</td>
			<td>Sigma-Aldrich (Interlab A.S., USA)</td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>Ethyl alcohol</td>
			<td>Merck (Darmstadt, Germany)</td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>Hexane</td>
			<td>Merck (Darmstadt, Germany)</td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>Magnesium sulfate</td>
			<td>Scharlau (Barcelona, Spain)</td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>N,N-dimethylacetamide</td>
			<td>Merck (Darmstadt, Germany)</td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>N,N-dimethylformamide</td>
			<td>Merck (Darmstadt, Germany)</td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>Palladium chloride</td>
			<td>Merck (Darmstadt, Germany)</td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>Phenylboronic acid</td>
			<td>Sigma-Aldrich (Interlab A.S., USA)</td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>Potassium acetate</td>
			<td>Merck (Darmstadt, Germany)</td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>Potassium carbonate</td>
			<td>Scharlau (Barcelona, Spain)</td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>Potassium hydroxide</td>
			<td>Merck (Darmstadt, Germany)</td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>Silica gel</td>
			<td>Merck (Darmstadt, Germany)</td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>Sodium tert-butoxide</td>
			<td>Merck (Darmstadt, Germany)</td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>Thianaphthene-2-boronic acid</td>
			<td>Sigma-Aldrich (Interlab A.S., USA)</td>
			<td></td>
			<td></td>
		</tr>
	</tbody>
</table>

palladium n-heterocyclic carbene complexes: synthesis from benzimidazolium salts and catalytic activity in carbon-carbon bond-forming reactions

给出了用于合成和随后从苯并咪唑鎓盐中纯化四种钯N-杂环卡宾络合物的详细和一般化方案。还提供了详细的和一般的方案用于测试这种络合物在芳基化和铃木 - Miyaura交叉偶联反应中的催化活性。显示了四种配合物在芳基化和铃木 - 宫崎型反应中的催化活性的代表性结果。对于所研究的每个反应，四种配合物中的至少一种成功地催化了反应，使它们成为催化许多碳 - 碳键形成反应的有希望的候选物。所提出的方案一般足以适应于新的钯N-杂环卡宾络合物的合成，纯化和催化活性测试。

苯并咪唑的盐（1 - 4）（ 图1）在无水DMF使用N- -alkylbenzimidazoles和各种烷基卤化物，然后纯化和表征合成为前18，24日报道。它们是白色或奶油色固体，产率在62％至97％之间。钯络合物NHC（5 - 8）（ 图2）然后，从盐，纯化的合成...

Watch this Scientific Journal Video about Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions at JoVE.com

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions

给出了用于合成和随后从苯并咪唑鎓盐中纯化四种钯N-杂环卡宾络合物的详细和一般化方案。在芳基化和Suzuki-Miyaura反应中测试复合物的催化活性。对于所研究的每个反应，四种配合物中的至少一种成功地催化了反应。

钯<em&gt;ñ</em&gt; - 杂环碳烯配合物：苯并咪唑盐的合成和碳 - 碳键合反应中的催化活性

Detailed and generalized protocols are presented for the synthesis and subsequent purification of four palladium N-heterocyclic carbene complexes from ...

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Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions

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Preparation and Use of Samarium Diiodide (SmI2) in Organic Synthesis: The Mechanistic Role of HMPA and Ni(II) Salts in the Samarium Barbier Reaction

Preparation and Use of Samarium Diiodide SmI2 in Organic Synthesis: The Mechanistic Role of HMPA and NiII Salts in the Samarium Barbier Reaction

二碘化钐的制备和使用（SMI<sub&gt; 2</sub&gt;）在有机合成中：HMPA和镍（II）盐的钐巴尔比耶反应的机理作用

Although initially considered an esoteric reagent, SmI2 has become a common tool for synthetic organic chemists. SmI2 is generated through the addition of ...

科研

化学

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

抗癌金属配合物的合成与细胞毒性评价MTT法

Titanium (IV) and vanadium (V) complexes are highly potent anticancer agents. A challenge in their synthesis refers to their hydrolytic instability; ...

Retropinacol/Cross-pinacol Coupling Reactions - A Catalytic Access to 1,2-Unsymmetrical Diols

Retropinacol /跨频哪醇偶联反应 - 催化访问1,2  - 非对称二醇

Unsymmetrical 1,2-diols are hardly accessible by reductive pinacol coupling processes. A successful execution of such a transformation is bound to a clear ...

Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-(phosphinetriyl)tripiperidine]}palladium Under Mild Reaction Conditions

Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions

Mizoroki-哎呀交叉偶联反应由二氯{双[1,1&#39;，1&#39;&#39;  - （phosphinetriyl）tripiperidine]}钯催化在温和的反应条件

Dichloro-bis(aminophosphine) complexes of palladium with the general formula of [(P{(NC5H10)3-n(C6H11)n})2Pd(Cl)2] (where n = 0-2), belong to a new family ...

Synthesis and Catalytic Performance of Gold Intercalated in the Walls of Mesoporous Silica

合成和金插在介孔二氧化硅的墙壁催化性能

As a promising catalytically active nano reactor, gold nanoparticles intercalated in mesoporous silica (GMS) were successfully synthesized and properties ...

Metal-free Synthesis of Ynones from Acyl Chlorides and Potassium Alkynyltrifluoroborate Salts

Ynones从酰氯和钾Alkynyltrifluoroborate盐无金属合成

Ynones are a valuable functional group and building block in organic synthesis. Ynones serve as a precursor to many important organic functional groups ...

The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes

The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes

一系列钌的合成，表征和反应<em&gt;Ñ</em&gt; -triphos<sup&gt;博士</sup&gt;配合

Herein we report the synthesis of a tridentate phosphine ligand N(CH2PPh2)3 (N-triphosPh) (1) via a phosphorus based Mannich reaction of the ...

Laboratory Production of Biofuels and Biochemicals from a Rapeseed Oil through Catalytic Cracking Conversion

通过催化裂化转换从菜籽油生物燃料和生物化学实验室生产

The work is based on a reported study which investigates the processability of canola oil (bio-feed) in the presence of bitumen-derived heavy gas oil ...

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine

酶联反应合成 l-赖氨酸手性氨基醇的研究

Amino alcohols are versatile compounds with a wide range of applications. For instance, they have been used as chiral scaffolds in organic synthesis. ...

Chemical Precipitation Method for the Synthesis of Nb2O5 Modified Bulk Nickel Catalysts with High Specific Surface Area

Chemical Precipitation Method for the Synthesis of Nb2O5 Modified Bulk Nickel Catalysts with High Specific Surface Area

化学沉淀法合成铌2O5改性高比表面积镍催化剂

We demonstrate a method for the synthesis of NixNb1-xO catalysts with sponge-like and fold-like nanostructures. By varying the Nb:Ni ratio, a series of ...