Name: a model to simulate clinically relevant hypoxia in humans
Uploaded: 2016-12-22T14:00:00
Description: Watch this Scientific Journal Video about A Model to Simulate Clinically Relevant Hypoxia in Humans at JoVE.com

Special thanks to all volunteers who participated in the original study. The work of L. Eichhorn was supported through a scholarship of the Else-Kr&#246;ner-Fresenius Foundation. The authors would like to thank Springer, Part of Springer Science+Business Media, for copyright clearance (License Number 3894660871180) and the kind permission of reusing previously published data.

윤리 문 인간의 참가자를 포함하는 연구에서 수행되는 모든 절차는 1964 년 헬싱키 선언의 윤리 기준과 그 이후의 개정에 따라했다. 이 연구의 디자인은 독일 본 대학 병원의 로컬 윤리위원회에 의해 승인되었다. 참고 : 주체가 어떤 항 고혈압 약의 무료 카페인거나 같은 물질과 같은 카테콜아민 유도 요원의 최소 24 시간 무료, 좋은 건강 상태에 있는지 확인하십시오. ?...

<ol>
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총 가사 시간은 주로 폐 크기 분당 산소 소비에 의해 발생 및 PCO이 증가 또는 PO이 감소에 기인하는 호흡 반사 견딜 수있는 개개인의 능력에 의해 영향을 받는다. 무호흡 다이버는 숨을 보류 지속 시간을 최대화하기 위해 훈련 및 최대 영감에 그렇게하는 데 사용됩니다. 따라서, 저산소증 때까지의 시간은 개인 사이의 검출 다릅니다과 피사체의 신체 조건과 훈련 상태에 따라, 심지...

임상 적으로 급성 저산소증과 동반 탄산 혈증은 대부분 폐쇄성 수면 무호흡 증후군 (OSAS), 급성기도 폐쇄 환자 나 심폐 소생술 동안 볼 수있다. OSAS 및 기타 저산소증 조건의 분야에서 주요 제한은 동물 연구에서 파생 된 병태 생리에 대한 인간의 모델이 존재하지 않는 1이라는 제한된 양도 지식을 포함한다. 7 - 인간의 저산소증을 모방하기 위해, 저산소 가스 혼합물은 지금까지 2 사용되어왔다. 그러나 이러한 조건은 저산소증, 일반적으로 탄산 혈증을 동반 임상 상황에보다 높은 고도에서 주변의 더 많은 대표입니다. 심장 정지 및 소생 동안 조직의 산소를 모니터링하기 위해 동물 연구는 생리 보상 메카니즘을 조사하기 위해 팔을 수행 하였다. Apneic 다이버가 호흡 충동을 누름 수있는 건강한 운동 선수그 낮은 동맥 산소 포화도 (9)와 증가 된 PCO (2) 10, 11에 의해 유발된다. 우리는 급성 저산소증과 동반 탄산 혈증 (12)의 임상 상황을 모방하기 위해 apneic 다이버를 조사 하였다. 이 모델은, 임상 설정 평가 OSAS 또는 병리학 호흡 장애가있는 환자의 병태 생리 학적 이해를 향상시키고, 무호흡의 경우 잠재적 인 카운터 밸런싱 메커니즘을 연구의 새로운 가능성을 나타 내기 위해 사용될 수있다. 또 다른 기술은 (상황을 환기 할 수없는, 즉,기도 장애물기도 수축 또는 삽관 할 수 없음) 또는 환자에서 간헐적 저산소증 시뮬레이션 인간 저산소증가 긴급 상황에 있는지 동적 저산소증의 경우 타당성과 정확성을 테스트 할 수있는 검출 OSAS와. 인간이 제한된에서 비 침습적 기술은 저산소증을 감지합니다. 주변 맥박 산소 측정기 (SPO 2) 사전 hospi에서 승인 된 도구입니다탈 병원 설정은 저산소증 (13)을 감지한다. 이 방법은 헤모글로빈의 흡광에 기초한다. 그러나, SPO이 측정은 말초 동맥 산소에 한정되고, 맥박 전기 활동 (PEA) 또는 중앙 집중식 최소 순환 (14)의 경우에 사용될 수 없다. 19 - 반면, 근적외선 분광법 출혈성 쇼크 지주막 하 출혈 (15)는 다음 중, PEA 동안 실시간으로 뇌 조직 산소 포화도 (RSO 2)을 평가하기 위해 사용될 수있다. 그것의 사용은 지속적으로 20 증가하고 방법 론적 연구는 SPO 2 RSO 2 3,4 사이에 양의 상관 관계를 밝혀왔다. 본 연구는 인간에서 임상 적으로 관련된 저산소증을 시뮬레이션 디 재 포화시 주변 산소 포화도와 NIRS를 비교하는 단계적인 방법을 제공하는 모델을 제공한다. (A)의 경우에 생리 데이터를 분석하여pnea 카운터 밸런싱 메커니즘에 대한 이해를 향상시킬 수있다.

<table border="0" cellpadding="0" cellspacing="0" width="352">
	<colgroup>
		<col span="4" />
	</colgroup>
	<tbody>
		<tr height="60">
			<td height="60" style="height:60px;width:88px;">SpO2</td>
			<td style="width:88px;">Dr&#228;ger Medical AG&#38;CO.KG</td>
			<td style="width:88px;">SHP ACC MCABLE-Masimo Set</td>
			<td style="width:88px;">peripheral SpO2-Monitoring</td>
		</tr>
		<tr height="80">
			<td height="80" style="height:80px;width:88px;">Non Invasive Blood Pressure (NIBP)</td>
			<td style="width:88px;">Dr&#228;ger Medical AG&#38;CO.KG</td>
			<td style="width:88px;">NIBP cuff M+,&#160; MP00916&#160;</td>
			<td style="width:88px;"></td>
		</tr>
		<tr height="60">
			<td height="60" style="height:60px;width:88px;">Electrocardiographic (ECG) &#160;</td>
			<td style="width:88px;">Dr&#228;ger Medical AG&#38;CO.KG</td>
			<td style="width:88px;">Infinity M540 Monitor</td>
			<td style="width:88px;">ECG monitoring</td>
		</tr>
		<tr height="60">
			<td height="60" style="height:60px;width:88px;">Docking station</td>
			<td style="width:88px;">Dr&#228;ger Medical AG&#38;CO.KG</td>
			<td style="width:88px;">M500 Docking Station</td>
			<td style="width:88px;">connection of M540 to laptop</td>
		</tr>
		<tr height="80">
			<td height="80" style="height:80px;width:88px;">NIRS</td>
			<td style="width:88px;">NONIN Medical&#8217;s EQUANOX</td>
			<td style="width:88px;">Model 7600 Regional Oximeter System</td>
			<td style="width:88px;">measuring of cerebral and&#160; tissue oxygenation</td>
		</tr>
		<tr height="120">
			<td height="120" style="height:120px;width:88px;">NIRS diodes</td>
			<td style="width:88px;">EQUANOX Advance Sensor</td>
			<td style="width:88px;">Model 8004CA</td>
			<td style="width:88px;">suited for measuring cerebral and somatic oxygen-saturation</td>
		</tr>
		<tr height="20">
			<td height="20" style="height:20px;width:88px;">Laptop&#160;</td>
			<td style="width:88px;"></td>
			<td style="width:88px;"></td>
			<td style="width:88px;"></td>
		</tr>
		<tr height="80">
			<td height="80" style="height:80px;width:88px;">DataGrabber</td>
			<td style="width:88px;">Dr&#228;ger Medical AG&#38;CO.KG</td>
			<td style="width:88px;">DataGrabber v2005.10.16</td>
			<td style="width:88px;">software to synchronize M540 with laptop</td>
		</tr>
		<tr height="80">
			<td height="80" style="height:80px;width:88px;">eVision</td>
			<td style="width:88px;">Nonin Medical. Inc.</td>
			<td style="width:88px;">Version 1.3.0.0</td>
			<td style="width:88px;">software to synchronize NONIN with laptop</td>
		</tr>
	</tbody>
</table>

a model to simulate clinically relevant hypoxia in humans

In case of apnea, arterial partial pressure of oxygen (pO2) decreases, while partial pressure of carbon dioxide (pCO2) increases. To avoid damage to hypoxia sensitive organs such as the brain, compensatory circulatory mechanisms help to maintain an adequate oxygen supply. This is mainly achieved by increased cerebral blood flow. Intermittent hypoxia is a commonly seen phenomenon in patients with obstructive sleep apnea. Acute airway obstruction can also result in hypoxia and hypercapnia. Until now, no adequate model has been established to simulate these dynamics in humans. Previous investigations focusing on human hypoxia used inhaled hypoxic gas mixtures. However, the resulting hypoxia was combined with hyperventilation and is therefore more representative of high altitude environments than of apnea. Furthermore, the transferability of previously performed animal experiments to humans is limited and the pathophysiological background of apnea induced physiological changes is poorly understood. In this study, healthy human apneic divers were utilized to mimic clinically relevant hypoxia and hypercapnia during apnea. Additionally, pulse-oximetry and Near Infrared Spectroscopy (NIRS) were used to evaluate changes in cerebral and peripheral oxygen saturation before, during, and after apnea.

한 환자 중 무호흡증 1 표시를 SPO 2 NIRS 값 (NIRS 뇌와 NIRS 조직)의 동시 녹음을줍니다. 총 무호흡 시간은 363 초였다. 다음 무호흡증 NIRS와 SPO 2 값은 약 140 초 동안 안정적으로 유지. NIRS의 뇌의 감소가 238 초 후 검출 된 반면, SPO 2의 감소는 주변 SPO 2 204 초 후 검출되었다. 가장 낮은 측정 SPO ...

Watch this Scientific Journal Video about A Model to Simulate Clinically Relevant Hypoxia in Humans at JoVE.com

A Model to Simulate Clinically Relevant Hypoxia in Humans

인간 저산소증 시뮬레이션 보통 저산소 가스 혼합물을 흡입에 의해 수행되었다. 이 연구를 위해, apneic 다이버는 인간의 동적 저산소증을 시뮬레이션하는 데 사용되었다. 또한, 불포화 재 포화 반응 속도의 생리적 변화는 이러한 근 적외선 분광법 (NIRS) 및 말초 산소 포화도 (SPO 2)와 같은 비 침습적 도구를 사용하여 평가 하였다.

A 모델은 인간의 임상 관련 저산소증을 시뮬레이션하기

In case of apnea, arterial partial pressure of oxygen (pO2) decreases, while partial pressure of carbon dioxide (pCO2) increases. To avoid damage to ...

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