単一細胞レベルでのキャビテーション気泡（複数可） - 細胞相互作用し、得られた生体効果を調査するための表面パターニングとマイクロ流体システム

A microfluidic chip was fabricated to produce pairs of gold dots for tandem bubble generation and fibronectin-coated islands for single-cell patterning nearby. The resultant flow field was characterized by particle image velocimetry and was employed to study various bioeffects, including cell membrane poration, membrane deformation, and intracellular calcium response.