Name: improving strength, power, muscle aerobic capacity, and glucose tolerance through short-term progressive strength training among elderly people
Uploaded: 2017-07-05T12:30:00
Description: Watch this Scientific Journal Video about Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People at JoVE.com

Forfatterne er taknemmelige for Andrée Nienkerk, Dennis Peyron og Sebastian Skjöld for at overvåge træningssessionerne og flere tests; Til de emner, der deltager Til Tim Crosfield til sprogrevision; Og til den økonomiske støtte fra Svensk Skole for Idræt og Sundhedsvidenskab.

Det regionale etiske udvalg i Stockholm, Sverige, godkendte udformningen af ​​undersøgelsen. 1. Materiale <ol><li> Rekruttere relativt sunde kvinder og mænd 65-80 år, der har BMI værdier mellem 20 og 30 kg · m -2 . Randomize dem i to grupper. Sørg for, at individer i begge grupper har relativt lave fysiske aktivitetsniveauer ( dvs. moderat daglig fysisk aktivitet og ingen regelmæssig træning). </li><li> Udelukkende betablokkere og personer med kronisk hjerte...

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I denne undersøgelse har en række teknikker været anvendt til at undersøge virkningerne af kortvarig progressiv modstandstræning på ældre individs muskelfunktion / morfologi, aerob kapacitet og glukosetolerance. Hovedresultaterne var, at der i sammenligning med en kontrolgruppe forekom mange forbedringer i muskel-aerob kapacitet, glukosetolerance, styrke, magt og muskelkvalitet ( dvs. protein involveret i celle-signalering og muskelfibersammensætning). En stigning blev for eksempel set for: statisk, exc...

Aldring er forbundet med tab af muskelmasse (sarkopi), styrke og kraft. Reduceret styrke, og sandsynligvis endnu vigtigere, strøm, resulterer i immobilitet, en øget risiko for skade og en reduceret livskvalitet. Modstandstræning er en velkendt strategi til at modvirke sarkopi og forringe muskelfunktionen. Et groft estimat af muskelstyrke kan opnås ud fra belastningen eller antallet af opnåede gentagelser. Denne undersøgelse fik imidlertid mere detaljeret og præcis information om muskelfunktion ved anvendelse af et isokinetisk dynamometer til at indsamle information om drejningsmomentet under isometrisk, koncentrisk og excentrisk sammentrækning samt på kinetikken af ​​kraftudvikling. Aerob kapacitet, både på hele kropsniveauet (VO 2max ) og i skeletmuskel, reduceres hos ældre. Faldet i hjertefrekvens med alder forklarer en stor del af faldet i VO 2max 1 , men reduceret musRen oxidativ kapacitet, der i høj grad er relateret til nedsat fysisk aktivitet 2 , bidrager. Forringet mitokondriel funktion kan også være involveret i udviklingen af ​​sarkopi og insulinresistens 3 . Den muskel-aerobiske kapacitet blev vurderet i muskelbiopsier gennem biokemiske analyser af indholdet af mitokondrie-enzymer og proteinkomplekser placeret både i matrixen ( dvs. citratsyntase) og den indre mitokondrielle membran. Derudover blev histokemiske teknikker brugt til at måle effekten af ​​modstandstræning på muskelmorfologi ( dvs. sammensætning af fibertype, fiber tværsnitsareal og kapillærtæthed). En alternativ metode til vurdering af muskel-aerob kapacitet er at anvende magnetisk resonansspektroskopi til at måle hastigheden af ​​kreatinphosphatresyntese efter træningsfremkaldt udtømning 4 . Denne metode giver et estimat af in vivo muskel aerob kapacitY men kan ikke diskriminere mellem mitokondriel dysfunktion og kredsløbssygdomme. Desuden begrænser de høje omkostninger ved udstyr anvendelsen af ​​denne teknik i de fleste laboratorier. Aerob kapacitet (VO 2max og mitokondrieltæthed) kan forbedres ved udholdenhedsøvelse hos både unge og gamle 5 , 6 . Effekten af ​​modstandstræning på disse parametre er imidlertid blevet undersøgt mindre, især hos ældre personer, og resultaterne er modstridende 7 , 8 , 9 , 10 . Type 2 diabetes er en udbredt sygdom hos den ældre befolkning. Fysisk inaktivitet og fedme er vigtige livsstilsrelaterede faktorer, der forklarer den øgede forekomst af type 2 diabetes. Lavintensiv aerob træning anbefales ofte til personer med nedsat glukosetolerance. Det er dog ikkeLær hvordan styrketrening hos ældre påvirker glukosetolerance / insulinfølsomhed 11 , 12 . Den mest nøjagtige måde at måle insulinfølsomhed på er at anvende glukoseklemmeteknikken, hvor blodglukosen opretholdes konstant ved glucoseinfusion under betingelser med forhøjet insulin 13 . Ulemperne med denne teknik er, at det er tidskrævende og invasiv (arteriel kateterisering) og kræver særlige laboratoriefaciliteter. I denne undersøgelse blev den oral glukosetolerancetest, som er almindelig i sundhedsenheder, brugt. Denne metode er egnet, når flere emner skal undersøges i en begrænset periode. Prøvningen og tidslinjen for den eksperimentelle procedure kan opsummeres som følger. Brug tre separate dage til test før og efter en otte-ugers periode med samme arrangement og tilnærmede tidsplaner (≥24 timer mellem hver dag &lt;<html> Stærk&gt; Figur 1). På den første testdag måles: antropometriske data, såsom højde, kropsmasse, fedtfri masse (FFM) og øvre ben omkreds ( dvs. 15 cm over apex patellae i en afslappet liggende stilling); Submaximal cykliske evne; Og knæmuskelstyrke som beskrevet i trin 4 og 5. Tag en muskelbiopsi fra låret på den anden testdag. For yderligere beskrivelser, se trin 6.1. Test oral glukosetolerance (OGTT) på den sidste testdag. For yderligere beskrivelser, se trin 7.1. Bed alle deltagere om at undgå kraftig fysisk aktivitet i 24 timer og hurtigere natten over før hver testdag. Men bed dem om at undgå anstrengende fysisk aktivitet i 48 timer før OGTT testdagen. Bed dem om at følge deres normale daglige fysiske aktivitet og kostvaner. Bemærk, at før og efter interventionen var begge gruppers selvrapporterede fødeindtag og type fødevarer uændrede. Figimg &quot;src =&quot; / files / ftp_upload / 55518 / 55518fig1.jpg &quot;/&gt; Figur 1: Eksperimentel protokol. Skematisk diagram. Tidspunktet mellem de tre før- og efterprøver var ens for hvert fag og var mindst 24 timer. Yderligere oplysninger findes i teksten. Denne figur er blevet modificeret fra Frank et al. Scand. J. Med. Sci. Sport . 2016: 26, 764-73. 28 <a href="http://ecsource.jove.com/files/ftp_upload/55518/55518fig1large.jpg" target="_blank">Klik venligst her for at se en større version af denne figur.</a> Denne undersøgelse forsøgte at undersøge effekten af ​​kortsigtet modstandstræning hos ældre på muskeloxidativ kapacitet og glukosetolerance. Det andet mål var at undersøge effekten på styrke, styrke og muskelkvalitativ forbedring ( dvs. proteiner involveret i cellesignalering og sammensætning af muskelfibre).

<table border="0" cellpadding="0" cellspacing="0" width="1264">
	<tbody>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Western blot</td>
			<td style="width:479px;"></td>
			<td style="width:148px;"></td>
			<td style="width:167px;"></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Pierce 660nm Protein Assay Kit</td>
			<td>Thermo Scientific, Rockford, IL, USA</td>
			<td align="right">22662</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">SuperSignal West Femto Maximum Sensitivity Substrate&#160;</td>
			<td>Thermo Scientific</td>
			<td align="right">34096</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Halt Protease Inhibitor Cocktail (100X)&#160;</td>
			<td>Thermo Scientific</td>
			<td align="right">78429</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Restore PLUS Western Blot Stripping Buffer</td>
			<td>Thermo Scientific</td>
			<td align="right">46430</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Pierce Reversible Protein Stain Kit for PVDF Membranes</td>
			<td>Thermo Scientific</td>
			<td align="right">24585</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">10 st - 4&#8211;20% Criterion TGX Gel, 18 well, 30 &#181;l&#160;</td>
			<td>Bio-Rad Laboratories, Richmond, CA, USA</td>
			<td style="width:148px;">567-1094</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Immun-Blot PVDF Membrane&#160;</td>
			<td>Bio-Rad</td>
			<td>162-0177</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Precision Plus Protein Dual Color Standards&#160;</td>
			<td>Bio-Rad</td>
			<td>161-0374</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">2x Laemmli Sample Buffer</td>
			<td>Bio-Rad</td>
			<td>161-0737</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">10x Tris/Glycine</td>
			<td>Bio-Rad</td>
			<td>161-0771</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">2-Mercaptoethanol</td>
			<td>Bio-Rad</td>
			<td>161-0710</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Tween 20</td>
			<td>Bio-Rad</td>
			<td>P1379-250ML</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Band analysis with Quantity One version 4.6.3.software</td>
			<td>Bio-Rad</td>
			<td></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">1% phosphatase inhibitor coctail</td>
			<td style="width:479px;">Sigma-Aldrich, Saint Louis, Missouri, USA</td>
			<td></td>
			<td></td>
		</tr>
		<tr height="25">
			<td height="25" style="height:25px;width:471px;">Name</td>
			<td style="width:479px;">Company</td>
			<td style="width:148px;">Catalog Number</td>
			<td>Comments</td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Antibodies</td>
			<td style="width:479px;"></td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">mTOR (1:1000)</td>
			<td>Cell Signaling, Danvers, Massachusetts, USA</td>
			<td align="right" style="width:148px;">2983</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Akt (1:1000)</td>
			<td>Cell Signaling, Danvers</td>
			<td align="right" style="width:148px;">9272</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Secondary anti-rabbit and anti-mouse HRP-linked (1:10000)</td>
			<td>Cell Signaling, Danvers</td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Citrate synthase (CS) (1:1000)</td>
			<td>Gene tex, San Antonio, California, USA</td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">OXPHOS (1:1000)</td>
			<td>Abcam, Cambridge, UK</td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="26">
			<td height="26" style="height:26px;width:471px;">Name</td>
			<td style="width:479px;">Company</td>
			<td style="width:148px;">Catalog Number</td>
			<td>Comments</td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Equipment - Analysis of muscle samples</td>
			<td></td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Bullet Blender 1.5 for homogenizing</td>
			<td>Next Advance, New York, USA</td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Plate reader</td>
			<td>Tecan infinite F200 pro, M&#228;nnedorf, Switzerland</td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="38">
			<td height="38" style="height:38px;width:471px;">Name</td>
			<td style="width:479px;">Company</td>
			<td style="width:148px;">Catalog Number</td>
			<td>Comments</td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Histochemistry</td>
			<td style="width:479px;"></td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Mayer hematoxylin</td>
			<td style="width:479px;">HistoLab, V&#228;stra Fr&#246;lunda, Sweden&#160;</td>
			<td align="right" style="width:148px;">1820</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Oil Red o</td>
			<td style="width:479px;">Sigma-Aldrich, Saint Louis, Missouri, USA</td>
			<td style="width:148px;">00625-25y</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">NaCl</td>
			<td style="width:479px;">Sigma-Aldrich</td>
			<td style="width:148px;">793566-2.5 kg</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Cobalt Chloride</td>
			<td style="width:479px;">Sigma-Aldrich</td>
			<td style="width:148px;">60818-50G</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Amylase</td>
			<td style="width:479px;">Sigma-Aldrich</td>
			<td style="width:148px;">A6255-25MG</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">ATP</td>
			<td style="width:479px;">Sigma-Aldrich</td>
			<td style="width:148px;">A2383-5G</td>
			<td></td>
		</tr>
		<tr height="22">
			<td height="22" style="height:22px;width:471px;">Glycine</td>
			<td style="width:479px;">VWR-chemicals / VWR-international, Sp&#229;nga, Sweden</td>
			<td style="width:148px;">101196X</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Calcium Chloride</td>
			<td style="width:479px;">VWR-chemicals / VWR-international</td>
			<td style="width:148px;">22328.262</td>
			<td></td>
		</tr>
		<tr height="22">
			<td height="22" style="height:22px;width:471px;">Iso-pentane</td>
			<td style="width:479px;">VWR-chemicals / VWR-international</td>
			<td style="width:148px;">24872.298</td>
			<td></td>
		</tr>
		<tr height="22">
			<td height="22" style="height:22px;width:471px;">Etanol 96%</td>
			<td style="width:479px;">VWR-chemicals / VWR-international</td>
			<td style="width:148px;">20905.296</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">NaOH</td>
			<td style="width:479px;">MERCK, Stockholm, Sweden</td>
			<td style="width:148px;">1.06498.1000</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Na acetate</td>
			<td style="width:479px;">MERCK</td>
			<td style="width:148px;">1.06268.1000</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">KCl</td>
			<td style="width:479px;">MERCK</td>
			<td style="width:148px;">1.04936.1000</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Ammonium Sulphide</td>
			<td style="width:479px;">MERCK</td>
			<td style="width:148px;">U1507042828</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Acetic acid 100%</td>
			<td style="width:479px;">MERCK</td>
			<td style="width:148px;">1.00063.2511</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Schiffs&#180; Reagent</td>
			<td style="width:479px;">MERCK</td>
			<td style="width:148px;">1.09033.0500</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Periodic acid</td>
			<td style="width:479px;">MERCK</td>
			<td style="width:148px;">1.00524.0025</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Chloroform</td>
			<td style="width:479px;">MERCK</td>
			<td style="width:148px;">1.02445.1000</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">pH-meter LANGE</td>
			<td style="width:479px;">HACH LANGE GMBH, Dusseldorf, Germany</td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Light microscope</td>
			<td>Olympus BH-2, Olympus, Tokyo, Japan</td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Cryostat&#160; Leica CM1950</td>
			<td>Leica Microsystems, Wetzlar, Germany</td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Leica software Leica Qwin V3</td>
			<td>Leica Microsystems</td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Gel Doc 2000 - Bio-Rad, camera setup</td>
			<td>Bio-Rad Laboratories AB, Solna, Sweden&#160;</td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Software program Quantift One - 4.6 (version 4.6.3; Bio Rad)</td>
			<td>Bio-Rad Laboratories AB, Solna, Sweden&#160;</td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="23">
			<td height="23" style="height:23px;width:471px;">Name</td>
			<td style="width:479px;">Company</td>
			<td style="width:148px;">Catalog Number</td>
			<td>Comments</td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Oral glucos tolerance test, OGTT</td>
			<td style="width:479px;"></td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Glukos APL 75 g</td>
			<td>APL, Stockholm, Sweden</td>
			<td align="right">323,188</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Automated analyser Biosen 5140</td>
			<td>EKF Diagnostics, Barleben, Germany</td>
			<td></td>
			<td></td>
		</tr>
		<tr height="42">
			<td height="42" style="height:42px;width:471px;">Insulin and C-peptide in plasma kit ELISA</td>
			<td style="width:479px;">Mercodia AB, Uppsala Sweden</td>
			<td style="width:148px;">10-1132-01, 10-1134-01</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Plate reader</td>
			<td>Tecan infinite F200 pro, M&#228;nnedorf, Switzerland</td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="23">
			<td height="23" style="height:23px;width:471px;">Name</td>
			<td style="width:479px;">Company</td>
			<td style="width:148px;">Catalog Number</td>
			<td>Comments</td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Further equipment</td>
			<td style="width:479px;"></td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Measures of fat-free-mass</td>
			<td>FFM-Tanita T5896, Tanita, Tokyo, Japan</td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Strength training equipment for all training exercises</td>
			<td style="width:479px;">Cybex International Inc., Medway, Massachusetts, USA&#160;</td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Cycle ergometer&#160;</td>
			<td>Monark Ergometer 893E, Monark Exercises, Varberg, Sweden&#160;</td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Heart rate monitor RS800, Polar</td>
			<td style="width:479px;">Polar Electro OY, Kampele, Finland</td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Oxycin-Pro - automatic ergo-spirometric device</td>
			<td>Erich Jaeger GmbH, Hoechberg, Germany</td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Isokinetic dynamometer, Isomed 2000, knee muscle strength</td>
			<td style="width:479px;">D&#38;R Ferstl GmbH, Henau, Germany</td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">CED 1401 data acquisition system and Signal software</td>
			<td>Cambridge Electronic Design, Cambridge, UK</td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Software for muscle strength analysis, Spike 2, version 7</td>
			<td style="width:479px;">Signal Hound, LA Center, WA, USA</td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Statistica software for statistical analyses</td>
			<td>Statistica, Stat soft. inc, Tulsa, Oklahoma, USA</td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="23">
			<td height="23" style="height:23px;width:471px;">Name</td>
			<td style="width:479px;">Company</td>
			<td style="width:148px;">Catalog Number</td>
			<td>Comments</td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Muscle biopsy equipment</td>
			<td style="width:479px;"></td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Weil Blakesley conchotome</td>
			<td>Wisex, M&#246;lndal, Sweden</td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Local anesthesia&#160;</td>
			<td>Carbocain, 20 mL, 20 mg/mL; Astra Zeneca, S&#246;dert&#228;lje, Sweden</td>
			<td align="right" style="width:148px;">169,367</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Surgical Blade</td>
			<td style="width:479px;">Feather Safety Razor CO, LTD, Osaka, Japan&#160;</td>
			<td align="right" style="width:148px;">11048030</td>
			<td></td>
		</tr>
	</tbody>
</table>

improving strength, power, muscle aerobic capacity, and glucose tolerance through short-term progressive strength training among elderly people

Denne protokol beskriver samtidig brug af et bredt spektrum af metoder til at undersøge muskel-aerob kapacitet, glukosetolerance, styrke og effekt hos ældre, der udfører kortsigtet modstandstræning (RET). Overvågning af progressiv modstandstræning i 1 time tre gange om ugen i 8 uger blev udført af RET-deltagere (71 ± 1 år, intervall 65-80). Sammenlignet med en kontrolgruppe uden træning viste RET forbedringer af de foranstaltninger, der blev brugt til at indikere styrke, styrke, glukosetolerance og flere parametre for muskel-aerob kapacitet. Styrketræning blev udført i et motionscenter med kun robust træningsudstyr. Et isokinetisk dynamometer til knæforlængningsstyrke tillod måling af koncentrisk, excentrisk og statisk styrke, hvilket steg for RET-gruppen (8-12% efter-versus forprøve). Kraften (kraftfrekvensudviklingen, RFD) ved begyndelsen 0-30 ms viste også en stigning for RET-gruppen (52%). En glukosetolerance test med frequeNt blodglucosemålinger viste kun forbedringer for RET-gruppen i form af blodglukoseværdier efter 2 timer (14%) og området under kurven (21%). Blodlipidprofilen forbedredes også (8%). Fra muskelbiopsiprøver fremstillet ved hjælp af histokemi steg mængden af ​​fibertype IIa, og en tendens til et fald i IIx i RET-gruppen afspejlede en ændring til en mere oxidativ profil i form af fibersammensætning. Western blot (for at bestemme proteinindholdet relateret til signaleringen for muskelproteinsyntese) viste en stigning på 69% i både Akt og mTOR i RET-gruppen; Dette viste også en stigning i mitokondriale proteiner for OXPHOS-kompleks II og citratsyntase (begge ~ 30%) og for komplekse IV (90%), kun i RET-gruppen. Vi demonstrerer, at denne type progressiv modstandstræning giver forskellige forbedringer ( fx styrke, magt, aerob kapacitet, glukosetolerance og plasma lipidprofil).

Materiale I undersøgelsen deltog 21 relativt sunde kvinder og mænd, 65-80 år og med BMI værdier mellem 20 og 30 kg · m -2 og blev randomiseret i to grupper. Enkeltpersoner i begge grupper havde relativt lave fysiske aktivitetsniveauer ( dvs. et moderat dagligt fysisk aktivitetsniveau og ingen regelmæssig træning). En gruppe (n = 12, 6 kvinder og 6 mænd) udførte RET under en træner i 1 time tre gange ...

Watch this Scientific Journal Video about Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People at JoVE.com

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Effekten af ​​kortvarig modstandstræning på ældre blev undersøgt ved samtidig brug af flere metoder. Sammenlignet med en kontrolgruppe blev der set mange forbedringer, herunder muskel-aerob kapacitet, glukosetolerance, styrke, styrke og muskelkvalitet ( dvs. protein involveret i celle-signalering og sammensætning af muskelfibre).

Forbedring af styrke, magt, muskel-aerob kapacitet og glukosetolerance gennem kortvarig progressiv styrkeuddannelse blandt ældre mennesker

This protocol describes the simultaneous use of a broad span of methods to examine muscle aerobic capacity, glucose tolerance, strength, and power in ...

Research

Education

JoVE Core

JoVE Journal

Anatomy and Physiology

Medicine

Unit 1

Muscle Tissue

SCIENTISTS IN ACTION

Measuring the Strength of Mice

Måle styrken af ​​mus

Kondziela7 devised the inverted screen test and published it in 1964. It is a test of muscle strength using all four limbs. Most normal mice easily score ...

Manual Muscle Testing:  A Method of Measuring Extremity Muscle Strength Applied to Critically Ill Patients

Survivors of acute respiratory distress syndrome (ARDS) and other causes of critical illness often have generalized weakness, reduced exercise tolerance, ...

A Murine Model of Muscle Training by Neuromuscular Electrical Stimulation

En musemodel for muskeltræning ved Neuromuskulær elektrisk stimulering

Neuromuscular electrical stimulation (NMES) is a common clinical modality that is widely used to restore1, maintain2 or enhance3-5 muscle functional ...

Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test

Karakterisering af metaboliske status i ikke-humane primater med intravenøs glukose Tolerance Test

The intravenous glucose tolerance test (IVGTT) plays a key role in the characterization of glucose homeostasis. When taken together with serum biochemical ...

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Tilpasset Resistance Training Forbedrer Styrke i otte uger i Personer med multipel sklerose

Hip weakness is a common symptom affecting walking ability in people with multiple sclerosis (MS). It is known that resistance strength training (RST) can ...

Proximal Cadaveric Femur Preparation for Fracture Strength Testing and Quantitative CT-based Finite Element Analysis

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Cadaveric fracture testing is routinely used to understand factors that affect proximal femur strength.  Because ex vivo biological tissues are prone to ...

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

Fosfor-31 Magnetic Resonance Spectroscopy: et redskab til måling<em&gt; In vivo</em&gt; Mitokondrie Oxidativ phosphorylering Kapacitet i human skeletmuskulatur

Skeletal muscle mitochondrial oxidative phosphorylation (OXPHOS) capacity, which is critically important in health and disease, can be measured in vivo ...

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test (OGTT) and Insulin Tolerance Test (ITT)

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT

Undersøgelse af In Vivo glukosemetabolismen i høj-fedt kost-fed mus bruger Oral glukose Tolerance Test (OGTT) og Insulin Tolerance Test (ITT)

Obesity represents the most important single risk factor in the pathogenesis of type 2 diabetes, a disease which is characterized by a resistance to ...

Skeletal Muscle Neurovascular Coupling, Oxidative Capacity, and Microvascular Function with 'One Stop Shop' Near-infrared Spectroscopy

Skeletmuskulatur neurovaskulære kobling, Oxidative kapacitet og mikrovaskulære funktion med 'Et Stop Shop' nær-infrarød spektroskopi

Exercise represents a major hemodynamic stress that demands a highly coordinated neurovascular response in order to match oxygen delivery to metabolic ...

Muscle Imbalances: Testing and Training Functional Eccentric Hamstring Strength in Athletic Populations

Muskel ubalancer: Test og uddannelse funktionelle excentrisk forstrækning styrke i Athletic populationer

Many hamstring injuries that occur during physical activity occur while the muscles are lengthening, during eccentric hamstring muscle actions. Opposite ...