Name: improving strength, power, muscle aerobic capacity, and glucose tolerance through short-term progressive strength training among elderly people
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Description: Watch this Scientific Journal Video about Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People at JoVE.com

Forfatterne er takknemlige for Andrée Nienkerk, Dennis Peyron og Sebastian Skjöld for å veilede treningsøktene og flere tester; Til fagene som deltar Til Tim Crosfield for språkrevisjon; Og til økonomisk støtte fra Svensk Idrettshøgskole.

Det regionale etikkutvalget i Stockholm, Sverige, godkjente utformingen av undersøkelsen. 1. Materiale <ol><li> Rekruttere relativt friske kvinner og menn 65-80 år som har BMI verdier mellom 20 og 30 kg · m -2 . Slå dem i to grupper. Sørg for at individer i begge grupper har relativt lave fysiske aktivitetsnivåer ( dvs. moderat daglig fysisk aktivitet og ingen vanlig trening). </li><li> Utelukkende betablokkere og de med kronisk hjertesykdom og alvorlige nevrologi...

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I denne studien har en rekke teknikker blitt brukt til å undersøke effekten av kortvarig progressiv resistens trening på eldre pasients muskelfunksjon / morfologi, aerob kapasitet og glukosetoleranse. Hovedfunnet var at i sammenligning med en kontrollgruppe, oppsto mange forbedringer i muskel aerob kapasitet, glukosetoleranse, styrke, kraft og muskelkvalitet ( dvs. protein involvert i cellesignal og muskelfiberkomposisjon). En økning ble for eksempel sett for: statisk, eksentrisk og konsentrisk maksimal kne...

Aldring er forbundet med tap av muskelmasse (sarkopi), styrke og kraft. Redusert styrke, og nok enda viktigere, strøm, resulterer i ustabilitet, økt risiko for skade og redusert livskvalitet. Motstandstrening er en kjent strategi for å motvirke sarkopati og forverring av muskelfunksjonen. Et grovt anslag på muskelstyrken kan oppnås ved belastning eller antall oppnådde gjentakelser. Denne studien fikk imidlertid mer detaljert og nøyaktig informasjon om muskelfunksjonen ved å bruke et isokinetisk dynamometer for å samle informasjon om dreiemomentet under isometrisk, konsentrisk og eksentrisk sammentrekning, samt på kinetikken av kraftutvikling. Aerob kapasitet, både på hele kroppsnivå (VO 2max ) og i skjelettmuskelen, reduseres hos eldre. Nedgangen i hjertefrekvensen med alder forklarer en stor del av nedgangen i VO 2max 1 , men redusert musRen oksidativ kapasitet, i stor grad relatert til redusert fysisk aktivitet 2 , bidrar. Forringet mitokondriell funksjon kan også være involvert i utviklingen av sarkopi og insulinresistens 3 . Muskel aerob kapasitet ble vurdert i muskelbiopsier gjennom biokjemiske analyser av innholdet i mitokondrie enzymer og proteinkomplekser lokalisert både i matrisen ( dvs. citratsyntase) og den indre mitokondriamembranen. I tillegg ble histokemiske teknikker brukt til å måle effekten av motstandstrening på muskelmorfologi ( dvs. fibertype-sammensetning, fiber-tverrsnittsareal og kapillær tetthet). En alternativ metode for å vurdere muskel-aerob kapasitet ville være å bruke magnetisk resonansspektroskopi for å måle hastigheten av kreatinfosfatresyntese etter treningsinducert utmattelse 4 . Denne metoden gir et estimat av in vivo muskel aerob kapasitY, men kan ikke diskriminere mellom mitokondriell dysfunksjon og sirkulasjonsforstyrrelser. Videre begrenser de høye kostnadene ved utstyr bruken av denne teknikken i de fleste laboratorier. Aerob kapasitet (VO 2max og mitokondriell tetthet) kan forbedres ved utholdenhetstrening hos både unge og gamle 5 , 6 . Effekten av motstandstrening på disse parametrene har imidlertid blitt undersøkt mindre, særlig hos eldre personer, og resultatene er motstridende 7 , 8 , 9 , 10 . Type 2 diabetes er en utbredt sykdom hos eldre. Fysisk inaktivitet og fedme er viktige livsstilsrelaterte faktorer som forklarer den økte forekomsten av type 2 diabetes. Lav intensitet aerob trening anbefales ofte til personer med nedsatt glukosetoleranse. Det er imidlertid ukjentLær hvordan styrketrening hos eldre påvirker glukosetoleranse / insulinfølsomhet 11 , 12 . Den mest nøyaktige måten å måle insulinfølsomhet på, er å bruke glukoseklemmeteknikken, hvor blodsukkeret holdes konstant ved glukoseinfusjon under forhold med forhøyet insulin 13 . Ulempene ved denne teknikken er at det er tidkrevende og invasiv (arteriell kateterisering) og krever spesielle laboratoriefasiliteter. I denne studien ble den muntlige glukosetoleranse testen, som er vanlig i helsevesenene, brukt. Denne metoden er egnet når flere fag skal undersøkes i en begrenset periode. Testingen og tidslinjen for forsøksprosedyren kan oppsummeres som følger. Bruk tre separate dager for testing før og etter en periode på åtte uker, med samme arrangement og omtrentlige tidsplaner (≥24 timer mellom hver dag &lt;<html> Sterk&gt; Figur 1). På den første testdagen måles: antropometriske data, som høyde, kroppsmasse, fettfri masse (FFM) og øvre benomkrets ( dvs. 15 cm over apex-patellaen i en avslappet liggende stilling); Submaximal sykling evne; Og knemuskelstyrke, som beskrevet i trinn 4 og 5. Ta en muskelbiopsi fra låret på den andre testdagen. For ytterligere beskrivelser, se trinn 6.1. Test oral glukosetoleranse (OGTT) på den siste testdagen. For ytterligere beskrivelser, se trinn 7.1. Be alle deltakerne å unngå kraftig fysisk aktivitet i 24 timer og å raske over natten før hver testdag. Be dem imidlertid å unngå anstrengende fysisk aktivitet i 48 timer før OGTT test dagen. Be dem om å følge sin normale hverdagens fysiske aktivitet og kosthold. Merk at pre- og post-intervensjon, begge gruppers selvrapporterte matinntak og type mat var uendret. Figimg &quot;src =&quot; / files / ftp_upload / 55518 / 55518fig1.jpg &quot;/&gt; Figur 1: Eksperimentell protokoll. Skjematisk diagram. Tidspunktet mellom de tre før- og etterprøver var lik for hvert fag og var minst 24 timer. Ytterligere detaljer er gitt i teksten. Denne figuren er blitt modifisert fra Frank et al. Scand. J. Med. Sci. Sport . 2016: 26, 764-73. 28 <a href="http://ecsource.jove.com/files/ftp_upload/55518/55518fig1large.jpg" target="_blank">Vennligst klikk her for å se en større versjon av denne figuren.</a> Denne studien forsøkte å undersøke effekten av kortsiktig motstandstrening hos eldre på muskeloksidativ kapasitet og glukosetoleranse. Det andre målet var å undersøke effekten på styrke, kraft og muskelkvalitativ forbedring ( dvs. proteiner involvert i cellesignal og sammensetning av muskelfibertyper).

<table border="0" cellpadding="0" cellspacing="0" width="1264">
	<tbody>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Western blot</td>
			<td style="width:479px;"></td>
			<td style="width:148px;"></td>
			<td style="width:167px;"></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Pierce 660nm Protein Assay Kit</td>
			<td>Thermo Scientific, Rockford, IL, USA</td>
			<td align="right">22662</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">SuperSignal West Femto Maximum Sensitivity Substrate&#160;</td>
			<td>Thermo Scientific</td>
			<td align="right">34096</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Halt Protease Inhibitor Cocktail (100X)&#160;</td>
			<td>Thermo Scientific</td>
			<td align="right">78429</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Restore PLUS Western Blot Stripping Buffer</td>
			<td>Thermo Scientific</td>
			<td align="right">46430</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Pierce Reversible Protein Stain Kit for PVDF Membranes</td>
			<td>Thermo Scientific</td>
			<td align="right">24585</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">10 st - 4&#8211;20% Criterion TGX Gel, 18 well, 30 &#181;l&#160;</td>
			<td>Bio-Rad Laboratories, Richmond, CA, USA</td>
			<td style="width:148px;">567-1094</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Immun-Blot PVDF Membrane&#160;</td>
			<td>Bio-Rad</td>
			<td>162-0177</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Precision Plus Protein Dual Color Standards&#160;</td>
			<td>Bio-Rad</td>
			<td>161-0374</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">2x Laemmli Sample Buffer</td>
			<td>Bio-Rad</td>
			<td>161-0737</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">10x Tris/Glycine</td>
			<td>Bio-Rad</td>
			<td>161-0771</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">2-Mercaptoethanol</td>
			<td>Bio-Rad</td>
			<td>161-0710</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Tween 20</td>
			<td>Bio-Rad</td>
			<td>P1379-250ML</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Band analysis with Quantity One version 4.6.3.software</td>
			<td>Bio-Rad</td>
			<td></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">1% phosphatase inhibitor coctail</td>
			<td style="width:479px;">Sigma-Aldrich, Saint Louis, Missouri, USA</td>
			<td></td>
			<td></td>
		</tr>
		<tr height="25">
			<td height="25" style="height:25px;width:471px;">Name</td>
			<td style="width:479px;">Company</td>
			<td style="width:148px;">Catalog Number</td>
			<td>Comments</td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Antibodies</td>
			<td style="width:479px;"></td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">mTOR (1:1000)</td>
			<td>Cell Signaling, Danvers, Massachusetts, USA</td>
			<td align="right" style="width:148px;">2983</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Akt (1:1000)</td>
			<td>Cell Signaling, Danvers</td>
			<td align="right" style="width:148px;">9272</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Secondary anti-rabbit and anti-mouse HRP-linked (1:10000)</td>
			<td>Cell Signaling, Danvers</td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Citrate synthase (CS) (1:1000)</td>
			<td>Gene tex, San Antonio, California, USA</td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">OXPHOS (1:1000)</td>
			<td>Abcam, Cambridge, UK</td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="26">
			<td height="26" style="height:26px;width:471px;">Name</td>
			<td style="width:479px;">Company</td>
			<td style="width:148px;">Catalog Number</td>
			<td>Comments</td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Equipment - Analysis of muscle samples</td>
			<td></td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Bullet Blender 1.5 for homogenizing</td>
			<td>Next Advance, New York, USA</td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Plate reader</td>
			<td>Tecan infinite F200 pro, M&#228;nnedorf, Switzerland</td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="38">
			<td height="38" style="height:38px;width:471px;">Name</td>
			<td style="width:479px;">Company</td>
			<td style="width:148px;">Catalog Number</td>
			<td>Comments</td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Histochemistry</td>
			<td style="width:479px;"></td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Mayer hematoxylin</td>
			<td style="width:479px;">HistoLab, V&#228;stra Fr&#246;lunda, Sweden&#160;</td>
			<td align="right" style="width:148px;">1820</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Oil Red o</td>
			<td style="width:479px;">Sigma-Aldrich, Saint Louis, Missouri, USA</td>
			<td style="width:148px;">00625-25y</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">NaCl</td>
			<td style="width:479px;">Sigma-Aldrich</td>
			<td style="width:148px;">793566-2.5 kg</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Cobalt Chloride</td>
			<td style="width:479px;">Sigma-Aldrich</td>
			<td style="width:148px;">60818-50G</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Amylase</td>
			<td style="width:479px;">Sigma-Aldrich</td>
			<td style="width:148px;">A6255-25MG</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">ATP</td>
			<td style="width:479px;">Sigma-Aldrich</td>
			<td style="width:148px;">A2383-5G</td>
			<td></td>
		</tr>
		<tr height="22">
			<td height="22" style="height:22px;width:471px;">Glycine</td>
			<td style="width:479px;">VWR-chemicals / VWR-international, Sp&#229;nga, Sweden</td>
			<td style="width:148px;">101196X</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Calcium Chloride</td>
			<td style="width:479px;">VWR-chemicals / VWR-international</td>
			<td style="width:148px;">22328.262</td>
			<td></td>
		</tr>
		<tr height="22">
			<td height="22" style="height:22px;width:471px;">Iso-pentane</td>
			<td style="width:479px;">VWR-chemicals / VWR-international</td>
			<td style="width:148px;">24872.298</td>
			<td></td>
		</tr>
		<tr height="22">
			<td height="22" style="height:22px;width:471px;">Etanol 96%</td>
			<td style="width:479px;">VWR-chemicals / VWR-international</td>
			<td style="width:148px;">20905.296</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">NaOH</td>
			<td style="width:479px;">MERCK, Stockholm, Sweden</td>
			<td style="width:148px;">1.06498.1000</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Na acetate</td>
			<td style="width:479px;">MERCK</td>
			<td style="width:148px;">1.06268.1000</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">KCl</td>
			<td style="width:479px;">MERCK</td>
			<td style="width:148px;">1.04936.1000</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Ammonium Sulphide</td>
			<td style="width:479px;">MERCK</td>
			<td style="width:148px;">U1507042828</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Acetic acid 100%</td>
			<td style="width:479px;">MERCK</td>
			<td style="width:148px;">1.00063.2511</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Schiffs&#180; Reagent</td>
			<td style="width:479px;">MERCK</td>
			<td style="width:148px;">1.09033.0500</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Periodic acid</td>
			<td style="width:479px;">MERCK</td>
			<td style="width:148px;">1.00524.0025</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Chloroform</td>
			<td style="width:479px;">MERCK</td>
			<td style="width:148px;">1.02445.1000</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">pH-meter LANGE</td>
			<td style="width:479px;">HACH LANGE GMBH, Dusseldorf, Germany</td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Light microscope</td>
			<td>Olympus BH-2, Olympus, Tokyo, Japan</td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Cryostat&#160; Leica CM1950</td>
			<td>Leica Microsystems, Wetzlar, Germany</td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Leica software Leica Qwin V3</td>
			<td>Leica Microsystems</td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Gel Doc 2000 - Bio-Rad, camera setup</td>
			<td>Bio-Rad Laboratories AB, Solna, Sweden&#160;</td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Software program Quantift One - 4.6 (version 4.6.3; Bio Rad)</td>
			<td>Bio-Rad Laboratories AB, Solna, Sweden&#160;</td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="23">
			<td height="23" style="height:23px;width:471px;">Name</td>
			<td style="width:479px;">Company</td>
			<td style="width:148px;">Catalog Number</td>
			<td>Comments</td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Oral glucos tolerance test, OGTT</td>
			<td style="width:479px;"></td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Glukos APL 75 g</td>
			<td>APL, Stockholm, Sweden</td>
			<td align="right">323,188</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Automated analyser Biosen 5140</td>
			<td>EKF Diagnostics, Barleben, Germany</td>
			<td></td>
			<td></td>
		</tr>
		<tr height="42">
			<td height="42" style="height:42px;width:471px;">Insulin and C-peptide in plasma kit ELISA</td>
			<td style="width:479px;">Mercodia AB, Uppsala Sweden</td>
			<td style="width:148px;">10-1132-01, 10-1134-01</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Plate reader</td>
			<td>Tecan infinite F200 pro, M&#228;nnedorf, Switzerland</td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="23">
			<td height="23" style="height:23px;width:471px;">Name</td>
			<td style="width:479px;">Company</td>
			<td style="width:148px;">Catalog Number</td>
			<td>Comments</td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Further equipment</td>
			<td style="width:479px;"></td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Measures of fat-free-mass</td>
			<td>FFM-Tanita T5896, Tanita, Tokyo, Japan</td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Strength training equipment for all training exercises</td>
			<td style="width:479px;">Cybex International Inc., Medway, Massachusetts, USA&#160;</td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Cycle ergometer&#160;</td>
			<td>Monark Ergometer 893E, Monark Exercises, Varberg, Sweden&#160;</td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Heart rate monitor RS800, Polar</td>
			<td style="width:479px;">Polar Electro OY, Kampele, Finland</td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Oxycin-Pro - automatic ergo-spirometric device</td>
			<td>Erich Jaeger GmbH, Hoechberg, Germany</td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Isokinetic dynamometer, Isomed 2000, knee muscle strength</td>
			<td style="width:479px;">D&#38;R Ferstl GmbH, Henau, Germany</td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">CED 1401 data acquisition system and Signal software</td>
			<td>Cambridge Electronic Design, Cambridge, UK</td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Software for muscle strength analysis, Spike 2, version 7</td>
			<td style="width:479px;">Signal Hound, LA Center, WA, USA</td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Statistica software for statistical analyses</td>
			<td>Statistica, Stat soft. inc, Tulsa, Oklahoma, USA</td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="23">
			<td height="23" style="height:23px;width:471px;">Name</td>
			<td style="width:479px;">Company</td>
			<td style="width:148px;">Catalog Number</td>
			<td>Comments</td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Muscle biopsy equipment</td>
			<td style="width:479px;"></td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Weil Blakesley conchotome</td>
			<td>Wisex, M&#246;lndal, Sweden</td>
			<td style="width:148px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;">Local anesthesia&#160;</td>
			<td>Carbocain, 20 mL, 20 mg/mL; Astra Zeneca, S&#246;dert&#228;lje, Sweden</td>
			<td align="right" style="width:148px;">169,367</td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:471px;">Surgical Blade</td>
			<td style="width:479px;">Feather Safety Razor CO, LTD, Osaka, Japan&#160;</td>
			<td align="right" style="width:148px;">11048030</td>
			<td></td>
		</tr>
	</tbody>
</table>

improving strength, power, muscle aerobic capacity, and glucose tolerance through short-term progressive strength training among elderly people

Denne protokollen beskriver samtidig bruk av et bredt spekter av metoder for å undersøke muskel aerob kapasitet, glukosetoleranse, styrke og kraft hos eldre som utfører kortsiktig motstandstrening (RET). Overvåket progressiv motstandsopplæring i 1 time tre ganger i uken i 8 uker ble utført av RET-deltakere (71 ± 1 år, intervall 65-80). Sammenliknet med en kontrollgruppe uten trening viste RET forbedringer på tiltakene som ble brukt for å indikere styrke, kraft, glukosetoleranse og flere parametere av muskel-aerob kapasitet. Styrketrening ble utført i et treningsstudio med kun robust treningsutstyr. Et isokinetisk dynamometer for kneledningsstyrke tillot måling av konsentrisk, eksentrisk og statisk styrke, noe som økte for RET-gruppen (8-12% etter versus forprøve). Kraften (frekvensen av kraftutvikling, RFD) ved den første 0-30 ms viste også en økning for RET-gruppen (52%). En glukosetoleranse test med frittNt blodglukosemålinger viste forbedringer bare for RET-gruppen når det gjelder blodglukoseverdier etter 2 timer (14%) og arealet under kurven (21%). Blodlipidprofilen ble også forbedret (8%). Fra muskelbiopsiprøver fremstilt ved hjelp av histokjemi økte mengden fiber type IIa, og en trend mot en reduksjon i IIx i RET-gruppen reflekterte en endring til en mer oksidativ profil i form av fibersammensetning. Western blot (for å bestemme proteininnholdet knyttet til signalering for muskelproteinsyntese) viste en økning på 69% i både Akt og mTOR i RET-gruppen; Dette viste også en økning i mitokondriale proteiner for OXPHOS-kompleks II og citratsyntase (begge ~ 30%) og for komplekse IV (90%), i bare RET-gruppen. Vi demonstrerer at denne typen progressiv motstandstrening gir forskjellige forbedringer ( f.eks. Styrke, kraft, aerob kapasitet, glukosetoleranse og plasma lipidprofil).

Materiale I studien deltok 21 relativt friske kvinner og menn, 65-80 år og med BMI-verdier mellom 20 og 30 kg · m -2 og ble randomisert til to grupper. Personer i begge gruppene hadde relativt lave fysiske aktivitetsnivåer ( dvs. et moderat hverdagslig fysisk aktivitet og ingen vanlig trening). En gruppe (n = 12, 6 kvinner og 6 menn) utførte RET under en trener i 1 time tre ganger i uken i åtte uker, og d...

Watch this Scientific Journal Video about Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People at JoVE.com

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Effekten av kortsiktig motstandstrening hos eldre ble undersøkt ved samtidig bruk av flere metoder. Sammenlignet med en kontrollgruppe, ble det sett mange forbedringer, inkludert muskel-aerob kapasitet, glukosetoleranse, styrke, kraft og muskelkvalitet ( dvs. protein involvert i celle-signalering og sammensetning av muskelfibre).

Forbedre styrke, kraft, muskel aerob kapasitet og glukosetoleranse gjennom kortvarig progressiv styrketrening blant eldre mennesker

This protocol describes the simultaneous use of a broad span of methods to examine muscle aerobic capacity, glucose tolerance, strength, and power in ...

Research

Education

JoVE Core

JoVE Journal

Anatomy and Physiology

Medicine

Unit 1

Muscle Tissue

SCIENTISTS IN ACTION

Measuring the Strength of Mice

Måle styrke for Mus

Kondziela7 devised the inverted screen test and published it in 1964. It is a test of muscle strength using all four limbs. Most normal mice easily score ...

Manual Muscle Testing:  A Method of Measuring Extremity Muscle Strength Applied to Critically Ill Patients

Survivors of acute respiratory distress syndrome (ARDS) and other causes of critical illness often have generalized weakness, reduced exercise tolerance, ...

A Murine Model of Muscle Training by Neuromuscular Electrical Stimulation

En murint Model of Muscle Training ved nevromuskulær elektrisk stimulering

Neuromuscular electrical stimulation (NMES) is a common clinical modality that is widely used to restore1, maintain2 or enhance3-5 muscle functional ...

Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test

Karakterisering av Metabolsk Status i humane primater med intravenøs glukosetoleransetest

The intravenous glucose tolerance test (IVGTT) plays a key role in the characterization of glucose homeostasis. When taken together with serum biochemical ...

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Tilpasset Resistance Training Forbedrer styrke i åtte uker i Personer med multippel sklerose

Hip weakness is a common symptom affecting walking ability in people with multiple sclerosis (MS). It is known that resistance strength training (RST) can ...

Proximal Cadaveric Femur Preparation for Fracture Strength Testing and Quantitative CT-based Finite Element Analysis

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Cadaveric fracture testing is routinely used to understand factors that affect proximal femur strength.  Because ex vivo biological tissues are prone to ...

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

Fosfor-31 Magnetic Resonance spektroskopi: Et verktøy for måling<em&gt; I Vivo</em&gt; Mitokondriell oksidativ fosforylering Kapasitet i Human Skeletal Muscle

Skeletal muscle mitochondrial oxidative phosphorylation (OXPHOS) capacity, which is critically important in health and disease, can be measured in vivo ...

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test (OGTT) and Insulin Tolerance Test (ITT)

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT

Studie av i Vivo glukose metabolisme i fettrikt kosthold-matet mus muntlig glukose toleranse Test (OGTT) og Insulin toleranse Test (ITT)

Obesity represents the most important single risk factor in the pathogenesis of type 2 diabetes, a disease which is characterized by a resistance to ...

Skeletal Muscle Neurovascular Coupling, Oxidative Capacity, and Microvascular Function with 'One Stop Shop' Near-infrared Spectroscopy

Skjelettmuskel nevrovaskulære kopling og oksidativt kapasitet mikrovaskulær funksjon med 'One Stop Shop' nær infrarød spektroskopi

Exercise represents a major hemodynamic stress that demands a highly coordinated neurovascular response in order to match oxygen delivery to metabolic ...

Muscle Imbalances: Testing and Training Functional Eccentric Hamstring Strength in Athletic Populations

Muskelen ubalansene: Testing og opplæring funksjonelle eksentriske Hamstring styrke atletisk bestander

Many hamstring injuries that occur during physical activity occur while the muscles are lengthening, during eccentric hamstring muscle actions. Opposite ...