Name: cardiac magnetic resonance imaging at 7 tesla
Uploaded: 2019-01-06T13:00:00
Description: Watch this Scientific Journal Video about Cardiac Magnetic Resonance Imaging at 7 Tesla at JoVE.com

提交人承认昆士兰大学高级成像中心国家成像设施的设施和科学和技术援助。我们还要感谢格雷厄姆·加洛威和伊恩·布雷顿帮助索拉尔夫·尼恩多夫获得 caesie 赠款。

这项研究得到了澳大利亚昆士兰大学道德委员会的批准, 并从研究中包括的所有科目中获得了知情同意。
1. 科目
<ol><li>在昆士兰大学内部招聘18岁以上的志愿者科目。</li>
	<li>知情同意<ol>
<li>在进入磁共振成像 (mri) 安全区之前, 告知每个研究对象接受检查的潜在风险。具体而言, 讨论超高磁场暴露和可能的禁忌症进行核磁共振检查。通知参加考试的主体是自愿的, 在任何时候?...

<ol>
	<li>Kramer, C. M., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Standardized+cardiovascular+magnetic+resonance+(CMR)+protocols+2013+update.">Standardized cardiovascular magnetic resonance (CMR) protocols 2013 update.</a> Journal of Cardiovascular Magnetic Resonance. 15 (1), 1 (2013).</li><li>Earls, J. P., Ho, V. B., Foo, T. K., Castillo, E., Flamm, S. D. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Cardiac+MRI:+Recent+progress+and+continued+challenges.">Cardiac MRI: Recent progress and continued challenges.</a> Journal of Magnetic Resonance Imaging. 16 (2), 111-127 (2002).</li><li>Wintersperger, B. J., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Cardiac+CINE+MR+imaging+with+a+32-channel+cardiac+coil+and+parallel+imaging:+Impact+of+acceleration+factors+on+image+quality+and+volumetric+accuracy.">Cardiac CINE MR imaging with a 32-channel cardiac coil and parallel imaging: Impact of acceleration factors on image quality and volumetric accuracy.</a> Journal of Magnetic Resonance Imaging. 23 (2), 222-227 (2006).</li><li>Schmitt, M., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=A+128-channel+receive-only+cardiac+coil+for+highly+accelerated+cardiac+MRI+at+3+Tesla.">A 128-channel receive-only cardiac coil for highly accelerated cardiac MRI at 3 Tesla.</a> Magnetic Resonance in Medicine. 59 (6), 1431-1439 (2008).</li><li>Wech, T., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=High-resolution+functional+cardiac+MR+imaging+using+density-weighted+real-time+acquisition+and+a+combination+of+compressed+sensing+and+parallel+imaging+for+image+reconstruction.">High-resolution functional cardiac MR imaging using density-weighted real-time acquisition and a combination of compressed sensing and parallel imaging for image reconstruction.</a> R&#246;Fo: Fortschritte Auf Dem Gebiete Der R&#246;ntgenstrahlen Und Der Nuklearmedizin. 182 (8), 676-681 (2010).</li><li>St&#228;b, D., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=CAIPIRINHA+accelerated+SSFP+imaging.">CAIPIRINHA accelerated SSFP imaging.</a> Magnetic Resonance in Medicine. 65 (1), 157-164 (2011).</li><li>Gutberlet, M., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Influence+of+high+magnetic+field+strengths+and+parallel+acquisition+strategies+on+image+quality+in+cardiac+2D+CINE+magnetic+resonance+imaging:+comparison+of+1.5+T+vs.+3.0+T.">Influence of high magnetic field strengths and parallel acquisition strategies on image quality in cardiac 2D CINE magnetic resonance imaging: comparison of 1.5 T vs. 3.0 T.</a> European Radiology. 15 (8), 1586-1597 (2005).</li><li>Gutberlet, M., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Comprehensive+cardiac+magnetic+resonance+imaging+at+3.0+Tesla:+feasibility+and+implications+for+clinical+applications.">Comprehensive cardiac magnetic resonance imaging at 3.0 Tesla: feasibility and implications for clinical applications.</a> Investigative radiology. 41 (2), 154-167 (2006).</li><li>Kraff, O., Fischer, A., Nagel, A. M., M&#246;nninghoff, C., Ladd, M. E. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=MRI+at+7+tesla+and+above:+Demonstrated+and+potential+capabilities:+Capabilities+of+MRI+at+7T+and+Above.">MRI at 7 tesla and above: Demonstrated and potential capabilities: Capabilities of MRI at 7T and Above.</a> Journal of Magnetic Resonance Imaging. 41 (1), 13-33 (2015).</li><li>Moser, E., Stahlberg, F., Ladd, M. E., Trattnig, S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=7-T+MR-from+research+to+clinical+applications?.">7-T MR-from research to clinical applications?.</a> NMR in Biomedicine. 25 (5), 695-716 (2012).</li><li>Hecht, E. M., Lee, R. F., Taouli, B., Sodickson, D. K. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Perspectives+on+Body+MR+Imaging+at+Ultrahigh+Field.">Perspectives on Body MR Imaging at Ultrahigh Field.</a> Magnetic Resonance Imaging Clinics of North America. 15 (3), 449-465 (2007).</li><li>Niendorf, T., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=W(h)ither+human+cardiac+and+body+magnetic+resonance+at+ultrahigh+fields?+technical+advances,+practical+considerations,+applications,+and+clinical+opportunities:+Advances+in+ultrahigh+field+Cardiac+and+Body+Magnetic+Resonance.">W(h)ither human cardiac and body magnetic resonance at ultrahigh fields? technical advances, practical considerations, applications, and clinical opportunities: Advances in ultrahigh field Cardiac and Body Magnetic Resonance.</a> NMR in Biomedicine. 29 (9), 1173-1179 (2016).</li><li>Niendorf, T., Sodickson, D. K., Krombach, G. A., Schulz-Menger, J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Toward+cardiovascular+MRI+at+7+T:+clinical+needs,+technical+solutions+and+research+promises.">Toward cardiovascular MRI at 7 T: clinical needs, technical solutions and research promises.</a> European Radiology. 20 (12), 2806-2816 (2010).</li><li>Niendorf, T., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Progress+and+promises+of+human+cardiac+magnetic+resonance+at+ultrahigh+fields:+A+physics+perspective.">Progress and promises of human cardiac magnetic resonance at ultrahigh fields: A physics perspective.</a> Journal of Magnetic Resonance. 229, 208-222 (2013).</li><li>Hinton, D. P., Wald, L. L., Pitts, J., Schmitt, F. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Comparison+of+Cardiac+MRI+on+1.5+and+3.0+Tesla+Clinical+Whole+Body+Systems.">Comparison of Cardiac MRI on 1.5 and 3.0 Tesla Clinical Whole Body Systems.</a> Investigative Radiology. 38 (7), 436-442 (2003).</li><li>Ohliger, M. A., Grant, A. K., Sodickson, D. K. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Ultimate+intrinsic+signal-to-noise+ratio+for+parallel+MRI:+Electromagnetic+field+considerations.">Ultimate intrinsic signal-to-noise ratio for parallel MRI: Electromagnetic field considerations.</a> Magnetic resonance in medicine. 50 (5), 1018-1030 (2003).</li><li>Vaughan, J. T., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Whole-body+imaging+at+7T:+Preliminary+results.">Whole-body imaging at 7T: Preliminary results.</a> Magnetic Resonance in Medicine. 61 (1), 244-248 (2009).</li><li>Hezel, F., Thalhammer, C., Waiczies, S., Schulz-Menger, J., Niendorf, T. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=High+Spatial+Resolution+and+Temporally+Resolved+T2*+Mapping+of+Normal+Human+Myocardium+at+7.0+Tesla:+An+Ultrahigh+Field+Magnetic+Resonance+Feasibility+Study.">High Spatial Resolution and Temporally Resolved T2* Mapping of Normal Human Myocardium at 7.0 Tesla: An Ultrahigh Field Magnetic Resonance Feasibility Study.</a> PLOS ONE. 7 (12), e52324 (2012).</li><li>Suttie, J. J., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=7+Tesla+(T)+human+cardiovascular+magnetic+resonance+imaging+using+FLASH+and+SSFP+to+assess+cardiac+function:+validation+against+1.5+T+and+3+T.">7 Tesla (T) human cardiovascular magnetic resonance imaging using FLASH and SSFP to assess cardiac function: validation against 1.5 T and 3 T.</a> NMR in biomedicine. 25 (1), 27-34 (2012).</li><li>von Knobelsdorff-Brenkenhoff, F., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Cardiac+chamber+quantification+using+magnetic+resonance+imaging+at+7+Tesla-a+pilot+study.">Cardiac chamber quantification using magnetic resonance imaging at 7 Tesla-a pilot study.</a> European Radiology. 20 (12), 2844-2852 (2010).</li><li>Winter, L., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Comparison+of+three+multichannel+transmit/receive+radiofrequency+coil+configurations+for+anatomic+and+functional+cardiac+MRI+at+7.0T:+implications+for+clinical+imaging.">Comparison of three multichannel transmit/receive radiofrequency coil configurations for anatomic and functional cardiac MRI at 7.0T: implications for clinical imaging.</a> European Radiology. 22 (10), 2211-2220 (2012).</li><li>Schmitter, S., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Cardiac+imaging+at+7+tesla:+Single-+and+two-spoke+radiofrequency+pulse+design+with+16-channel+parallel+excitation:+Cardiac+Imaging+at+7T.">Cardiac imaging at 7 tesla: Single- and two-spoke radiofrequency pulse design with 16-channel parallel excitation: Cardiac Imaging at 7T.</a> Magnetic Resonance in Medicine. 70 (5), 1210-1219 (2013).</li><li>Krug, J., Rose, G., Stucht, D., Clifford, G., Oster, J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Limitations+of+VCG+based+gating+methods+in+ultra+high+field+cardiac+MRI.">Limitations of VCG based gating methods in ultra high field cardiac MRI.</a> Journal of Cardiovascular Magnetic Resonance. 15 (Suppl 1), W19 (2013).</li><li>St&#228;b, D., Roessler, J., O'Brien, K., Hamilton-Craig, C., Barth, M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=ECG+Triggering+in+Ultra-High+Field+Cardiovascular+MRI.">ECG Triggering in Ultra-High Field Cardiovascular MRI.</a> Tomography. 2 (3), 167-174 (2016).</li><li>Gr&#228;&#223;l, A., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Design,+evaluation+and+application+of+an+eight+channel+transmit/receive+coil+array+for+cardiac+MRI+at+7.0T.">Design, evaluation and application of an eight channel transmit/receive coil array for cardiac MRI at 7.0T.</a> European Journal of Radiology. 82 (5), 752-759 (2013).</li><li>Graessl, A., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Modular+32-channel+transceiver+coil+array+for+cardiac+MRI+at+7.0T.">Modular 32-channel transceiver coil array for cardiac MRI at 7.0T.</a> Magnetic Resonance in Medicine. 72 (1), 276-290 (2014).</li><li>Snyder, C. J., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Initial+results+of+cardiac+imaging+at+7+tesla.">Initial results of cardiac imaging at 7 tesla.</a> Magnetic Resonance in Medicine. 61 (3), 517-524 (2009).</li><li>Meloni, A., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Detailing+magnetic+field+strength+dependence+and+segmental+artifact+distribution+of+myocardial+effective+transverse+relaxation+rate+at+1.5,+3.0,+and+7.0+T:+Magnetic+Field+Dependence+of+Myocardial+R+2+*.">Detailing magnetic field strength dependence and segmental artifact distribution of myocardial effective transverse relaxation rate at 1.5, 3.0, and 7.0 T: Magnetic Field Dependence of Myocardial R 2 *.</a> Magnetic Resonance in Medicine. 71 (6), 2224-2230 (2014).</li><li>von Knobelsdorff-Brenkenhoff, F., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Assessment+of+the+right+ventricle+with+cardiovascular+magnetic+resonance+at+7+Tesla.">Assessment of the right ventricle with cardiovascular magnetic resonance at 7 Tesla.</a> Journal of Cardiovascular Magnetic Resonance. 15, 23 (2013).</li><li>Petersen, S. E., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Reference+ranges+for+cardiac+structure+and+function+using+cardiovascular+magnetic+resonance+(CMR)+in+Caucasians+from+the+UK+Biobank+population+cohort.">Reference ranges for cardiac structure and function using cardiovascular magnetic resonance (CMR) in Caucasians from the UK Biobank population cohort.</a> Journal of Cardiovascular Magnetic Resonance. 19 (1), (2017).</li><li>Frauenrath, T., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Feasibility+of+cardiac+gating+free+of+interference+with+electro-magnetic+fields+at+1.5+Tesla,+3.0+Tesla+and+7.0+Tesla+using+an+MR-stethoscope.">Feasibility of cardiac gating free of interference with electro-magnetic fields at 1.5 Tesla, 3.0 Tesla and 7.0 Tesla using an MR-stethoscope.</a> Investigative radiology. 44 (9), 539-547 (2009).</li><li>Frauenrath, T., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Acoustic+cardiac+triggering:+a+practical+solution+for+synchronization+and+gating+of+cardiovascular+magnetic+resonance+at+7+Tesla.">Acoustic cardiac triggering: a practical solution for synchronization and gating of cardiovascular magnetic resonance at 7 Tesla.</a> Journal of Cardiovascular Magnetic Resonance. 12 (1), 67 (2010).</li><li>Schroeder, L., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=A+Novel+Method+for+Contact-Free+Cardiac+Synchronization+Using+the+Pilot+Tone+Navigator.">A Novel Method for Contact-Free Cardiac Synchronization Using the Pilot Tone Navigator.</a> Proceedings of the International Society for Magnetic Resonance in Medicine. 24, 3103 (2016).</li></ol>

功能 cmr 检查可在特斯拉7成功进行。基于场强驱动的信噪比增益, 可以获得显著较高的空间分辨率的人的心脏的 cine 图像相比, 1.5 或 3 t。虽然在较低的临床场强 1, 30 下, 通常使用6至8毫米的切片厚度和1.2 至2.0 毫米的平面体素边缘长度, 但7特斯拉的测量可以以4毫米的切片厚度和各向同性的方式进行平面内分辨率为 1.0 mm。
在7特斯拉?...

心血管磁共振 (cmr) 是被证明的临床价值与越来越多的临床适应症 1,2。特别是, 心脏形态和功能的评估是非常重要的, 通常通过跟踪和可视化整个心脏周期的心脏运动, 使用分段呼吸保持二维 (2d) 电影 (cine) 成像技术。虽然需要高时空分辨率、高血心肌对比度和高信噪比 (snr), 但数据采集受到心脏和呼吸运动以及使用多种呼吸保持和需要的高度限制对于整个心脏或左心室覆盖往往会导致大量的扫描时间。并行成像、同时进行多切片成像或其他加速技术有助于解决与运动相关的约束3、4、5、6。
此外, 为了从较高磁场的固有信噪比增益中获益,b0 = 3 tesla 的高场系统越来越多地用于临床常规7,8。这一发展还鼓励了对超高场 (b0≥7 tesla, f≥298 mhz) cmr9、10、11、12、13、14的调查.在 snr 和血心肌对比度的增益固有的更高的场强有希望被转移到增强功能 cmr 使用空间分辨率超过今天的限制 15,16,17. 反过来, 预计将有新的可能性进行基于磁共振的心肌组织特征、代谢成像和微观结构成像.到目前为止, 已有几个小组已经证明了 cmr 在7特斯拉的可行性, 并已推出了专门定制的超高场技术 17,18, 19, 20, 21,22。关于这些有希望的发展, 超高场遗留集束弹药的潜力可被认为尚未开发 13。同时, 物理现象和实际障碍, 如磁场不均匀性、射频激发场 (rf) 不均匀性、非共振伪影、介电效应、局部组织加热和场强度等独立的射频功率沉积约束使超高场成像具有挑战性 10,17。后者用于控制射频诱导组织加热, 确保安全运行。此外, 基于心电图 (ecg) 的触发可能会受到磁流体动力 (mhd) 效应19、23、24 的显著影响。为了应对组织中短波长引起的挑战, 提出了在7 特斯拉为 cmr 量身定制的多元素收发器 rf 线圈阵列 21、25、26、27。并行射频传输为传输场整形提供了手段, 也称为 b1 + 闪烁, 可以减少磁场的不均匀性和易感性 18,28.虽然在目前阶段, 其中一些措施可能会增加实验的复杂性, 概念已被证明是有帮助的, 并可能转化为 cmr 1.5 t 或 3 t 的临床领域的优势。
目前, 二维平衡稳态无进动 (bssfp) cine 成像是 1.5 t 和3t1 临床功能 cmr 的参考标准。最近, 该序列在7特斯拉成功使用, 但仍有大量挑战.应用患者特异性b1 +闪烁和额外的 rf 线圈调整来管理射频功率沉积约束, 并对序列典型的带状伪影进行仔细的 b0 闪烁控制.左心室 (lv) 功能评估的平均扫描时间为 93分钟, 这些努力将检查时间延长到临床可接受的范围之外。在这里, 被破坏的梯度回波序列提供了一个可行的替代方案。在7特斯拉时, 报告了 lv 功能评估的总检查时间 (29±5) 分钟, 这与低场强21的临床成像方案吻合较好。因此, 破坏梯度回波为基础的 cmr 受益于超高场的 t1 松弛时间延长,从而增强了血液心肌对比度优于 1.5 t 梯度回波成像。这使得微妙的解剖结构 , 如心包 , 二尖瓣和三尖瓣 , 以及状肌肉很好地识别。一致的, 被宠坏的梯度回声为基础的心脏室定量在 7 tesla 与 lv 参数得出的 2d bssfp cine 成像在 1.5 t20。除此之外, 准确的右心室 (rv) 室量化最近证明了使用高分辨率破坏梯度回波序列在 7 tesra29 的可行性。
认识到 cmr 在超高领域的挑战和机遇, 这项工作提出了一个设置和协议定制的功能 cmr 收购上的调查 7 tesla 研究扫描仪。该协议概述了技术基础, 显示了如何克服障碍, 并提供了实际注意事项, 有助于将额外的实验开销控制在最低限度。与今天的临床实践相比, 拟议的成像协议是空间分辨率的四倍改进。它旨在为临床适应者、医生科学家、转化研究人员、应用专家、mr 放射技师、技术人员和进入该领域的新进入者提供指导。

<table border="0" cellpadding="0" cellspacing="0" style="width:572px;" width="573">
	<tbody>
		<tr height="21">
			<td height="21" style="height:21px;width:216px;">7 Tesla MRI system</td>
			<td style="width:71px;">Siemens</td>
			<td style="width:119px;"></td>
			<td style="width:167px;">Investigational Device</td>
		</tr>
		<tr height="42">
			<td height="42" style="height:42px;width:216px;">32-Channel -1H-Cardiac Coil</td>
			<td style="width:71px;">MRI.Tools GmbH</td>
			<td style="width:119px;"></td>
			<td>Transmit/Receive RF Coil for MR Imaging and Spectroscopy at 7.0 Tesla</td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:216px;">ECG Trigger Device</td>
			<td style="width:71px;">Siemens</td>
			<td style="width:119px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:216px;">Pulse Trigger Device</td>
			<td style="width:71px;">Siemens</td>
			<td style="width:119px;"></td>
			<td></td>
		</tr>
	</tbody>
</table>

cardiac magnetic resonance imaging at 7 tesla

cmr 具有超高磁场 (磁场强度 b 0≥7 tesla), 受益于高磁场强度所固有的信噪比 (snr) 优势, 并有可能提供更好的信号对比度和空间分辨率. 虽然取得了很好的成果, 但由于能量沉积的限制和传输场不均匀性和磁场不均匀等物理现象, 超高场 cmr 具有挑战性。此外, 磁流体力学效应使得数据采集与心脏运动的同步变得困难。目前, 对新型磁共振技术的探索正在应对这些挑战。如果所有的障碍都能克服, 超高场 cmr 可能会为功能 cmr、心肌组织表征、微观结构成像或代谢成像带来新的机会。认识到这一潜力, 我们展示了为 cmr 7 特斯拉量身定制的多通道射频 (rf) 线圈技术 , 以及高阶 b0 闪烁和心脏触发的备用信号, 有利于高保真函数 cmr。通过所提出的设置, 可以在检查时间内完成心脏室量化, 类似于在较低场强时完成的时间。为了分享这一经验并支持传播这一专业知识, 本工作描述了我们在7特斯拉为功能 cmr 量身定制的设置和协议。

图 4显示了志愿者心脏 cine 检查的代表性结果。显示的是短轴的舒张和收缩时间框架和人的心脏的四室长轴视图。与长轴视图 (图 4a、 4a、4a、4a) 相比, 短轴视图的空间分辨率 (图 4a、 4a、 4a、4a)明显较高。在短轴和长轴切片中, 图...

Watch this Scientific Journal Video about Cardiac Magnetic Resonance Imaging at 7 Tesla at JoVE.com

Cardiac Magnetic Resonance Imaging at 7 Tesla

超高场磁共振固有的灵敏度增益为心脏的高空间分辨率成像提供了希望。在这里, 我们描述了一个协议定制的功能心血管磁共振 (cmr) 在 7 tesla 使用先进的多通道射频线圈, 磁场闪烁和触发概念。

7号特斯拉的心脏磁共振成像

CMR at an ultra-high field (magnetic field strength B0&#160;&#8805; 7 Tesla) benefits from the signal-to-noise ratio (SNR) advantage inherent at higher ...

以下实验的总体目标是在 7 特斯拉的超高场强度下执行心脏的高保真功能心脏 MRI。这是通过 A.利用专为超高场强度定制的多通道射频线圈技术实现的。B.小心主题定位。C. 采用高阶 BO 闪闪发光和 D. 使用可用的 ECG 触发设备。心血管磁共振成像具有临床价值，适应症范围日益扩大。这种成像尤其与心肌功能评估有着深远的意义。超馈送，如7特斯拉，提供了一个大的信号噪声优势，可以转移到超过今天限制的spay-shous-lou-shus。反过来，我们期待心肌组织表征和微结构成像的新的可能性。7特斯拉的优点有时被一些实际的障碍和物理拉利现象抵消， 如， 此外， ECG 触发可以显著受到磁-流体动力学效应.认识到这些挑战，我们提出了一个设置和协议的功能在7特斯拉。拟议的成像方案包括空间分辨率与当今临床实践的四倍改进。与临床扫描仪不同，在 1 点 5 或 3 特斯拉下运行，超高现场扫描仪没有配备车身线圈，使用本地收发器阵列对于信号激发至关重要。因此，患者表必须准备好容纳操作专用 32 通道收发器 RF 线圈所需的额外硬件。本实验中使用的线圈由多个功率分路器、相移器和发射接收接口盒组成，此外，两个RF线圈部分将被放置在主体的下方和顶部。首先，将附加的射频线圈硬件放在患者表的顶端。将各个盒子与适当的 BNC 电缆连接。将接口盒连接到患者桌上的四个线圈插头。确保桌子上有足够的空间来保证主体在磁铁的等值中心内定位。如这里所示，这可以通过预先定义患者桌上线圈的点，在与不同身体高度的志愿者的初步测试中实现。将后线圈阵列放入患者餐桌上的预定义位置。将线圈与相应的接口盒连接。接下来，将前线圈阵列的四个模块及其接口连接起来，并放在一边以进行主体定位。告知主体成像程序，以及接受检查的潜在风险，并取得书面同意。在进入 MRI 安全区之前，执行 MRI 安全和金属筛查。由于成像是在到期时在呼吸保持期间进行的，因此一致的屏气是图像质量不可或缺的一部分。在扫描前指导呼吸技术。将主体的心脏放在后线圈阵列的中心位置。头部通常放在线圈接口盒连接器的顶部。仔细放置电缆和适当使用缓冲非常重要，并确保主体的舒适性和合规性。将心电图电极和触发装置连接到车身。将脉冲触发装置连接到主体的食指。第二个触发装置允许在严重心电图信号失真时进行切换。将安全挤压球交给主体。将前线圈放在主体的胸前。使用耳机和耳塞减少噪音暴露，并允许与主体通信。将主体驱动到扫描仪孔中。在继续工作之前，请检查通信系统和主题情况。嗨，你能听到我说话吗？你还好吗？我们即将启动扫描仪。使用基本定位器扫描验证参与者心脏在等心的正确定位。根据需要重新定位主题。接下来，开订垫片体积，使它完全覆盖心脏。使用非触发流补偿，2D 多回波闪存填充器序列计算三阶垫片电流。设置电流后，请确保在考试的剩余过程中，垫片体积和垫片电流保持不变。对于双斜切片规划，采用呼吸和心电图触发的 2D 闪存序列。呼吸总是在到期时举行。首先，规划轴向侦察器垂直的两室定化切片，并平行于隔膜壁。要优化图像对比度，请使用高翻转角度或使用分段电影采集。其次，通过二室阀和左心室的顶点，规划垂直于二室的四室局部切片。最后，获得七个短访问点位片垂直于四室局部切片，平行于 mitrial 阀，垂直于隔膜壁。根据需要调整视野。使用高分辨率、屏气、心电图触发、分段、2D 闪存序列执行电影采集。从左心室四室视图开始，也称为水平长轴。通过斜阀和三尖阀的中心以及左心室的顶点规划中央切片。盖住整个心脏。在单个呼吸保持过期期间扫描每个切片。继续使用左心室短轴切片。将它们垂直于水平长轴并平行于斜阀。从底座到顶点覆盖整个左心室。确保第一片在叶插入中准确定位在手套阀处。同样，获取每个切片与一个单独的呼吸保持和过期。此图显示了从左侧磁孔外的志愿者和右侧磁铁的等值中心获得的典型 ECG 跟踪。ECG 由于电磁场的干扰和磁-流体动力学效应（或 MHD 效应）而损坏。MHD 效应在心律失速大症流的心脏阶段中明显，在心电图示波律中，可视为 ST 段的严重失真。这损害了心脏周期内数据采集的 R 波识别和同步。此图显示了使用建议的协议获得的长轴视图的代表性舒张和收缩图像。由于ECG触发信号严重失真，因此利用脉冲触发进行采集。触发信号中的抖动诱发在 sistol 期间发音的次要运动伪影。此处显示具有代表性的短轴视图。平面中一毫米的非常高的空间分辨率清晰可见。即使采用厚度为四毫米的切片厚度，图像也为噪声和对比度提供充足的信号，以描绘心肌墙壁。在某些情况下，还可以看到传输场中破坏性干扰导致的信号空隙。7特斯拉允许我们执行非常高的特殊分辨率的Cneg切除。与 1.5 或 3 特斯拉相比，我们能够将空间分辨率提高 3 到 4。我们的结果表明，真菌MRI检查可以在7特斯拉成功进行，我们可以证明超场心血管成像的潜力。

Research

Education

JoVE Core

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Physics

Medicine

Unit 1

Magnetic Forces and Fields

SCIENTISTS IN ACTION

Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking

磁共振衍生的心肌劳损评估使用特征跟踪

Purpose: An accurate and practical method to measure parameters like strain in myocardial tissue is of great clinical value, since it has been shown, that ...

科研

医学

Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling

使用校准动脉自旋标记磁共振肺灌注显像定量

This demonstrates a MR imaging method to measure the spatial distribution of pulmonary blood flow in healthy subjects 
during normoxia (inspired O2, ...

Remote Magnetic Navigation for Accurate, Real-time Catheter Positioning and Ablation in Cardiac Electrophysiology Procedures

遥控磁导航导管定位准确，实时和心脏电生理消融程序

New remote navigation systems have been developed to improve current limitations of conventional manually guided catheter ablation in complex cardiac ...

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

磁共振扩散张量成像在神经退行性疾病的分析

Diffusion tensor imaging (DTI) techniques provide information on the microstructural processes of the cerebral white matter (WM) in vivo. The present ...

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse

心脏异常的实验性自身免疫性心肌炎的无创性评估磁共振成像显微镜在鼠标

Myocarditis is an inflammation of the myocardium, but only ~10% of those affected show clinical manifestations of the disease. To study the immune events ...

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging

跟踪乳腺建筑特色与检测乳腺癌的磁共振扩散张量成像

Breast cancer is the most common cause of cancer among women worldwide. Early detection of breast cancer has a critical role in improving the quality of ...

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease

骨骼肌疾病的定量磁共振成像

Quantitative magnetic resonance imaging (qMRI) describes the development and use of MRI to quantify physical, chemical, and/or biological properties of ...

Dynamic Contrast Enhanced Magnetic Resonance Imaging of an Orthotopic Pancreatic Cancer Mouse Model

原位胰腺癌小鼠模型的动态对比增强磁共振成像

Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) has been limitedly used for orthotopic pancreatic tumor xenografts due to severe ...

Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia

同时PET / MRI成像在小鼠脑缺氧缺血

Dynamic changes in tissue water diffusion and glucose metabolism occur during and after hypoxia in cerebral hypoxia-ischemia reflecting a bioenergetics ...

Phase Contrast Magnetic Resonance Imaging in the Rat Common Carotid Artery

大鼠颈总动脉的相位对比磁共振成像

Phase contrast magnetic resonance imaging (PC-MRI) is a noninvasive approach that can quantify flow-related parameters such as blood flow. Previous ...