La murino colina-carenti, etionina-completati (CDE) dieta modello della lesione epatica cronica
October 21st, 2017
•Jully Gogoi-Tiwari1, Julia Köhn-Gaone1, Corey Giles2, Dirk Schmidt-Arras3, Francis D. Gratte1,4, Caryn L. Elsegood1, Geoffrey W. McCaughan5,6,7, Grant A. Ramm8,9, John K. Olynyk10,11, Janina E.E. Tirnitz-Parker1,12
1School of Biomedical Sciences & Curtin Health Innovation Research Institute, Curtin University, 2School of Public Health & Curtin Health Innovation Research Institute, Curtin University, 3Institute of Biochemistry, Christian-Albrechts-University, 4School of Veterinary and Life Sciences, Murdoch University, 5Centenary Institute of Cancer Medicine and Cell Biology, The University of Sydney, 6Royal Prince Alfred Hospital, 7A.W. Morrow Gastroenterology and Liver Centre, 8QIMR Berghofer Medical Research Institute, 9Faculty of Medicine and Biomedical Sciences, The University of Queensland, 10Fiona Stanley and Fremantle Hospitals, 11School of Medical and Health Sciences, Edith Cowan University, 12School of Medicine and Pharmacology, University of Western Australia
Qui descriviamo un metodo comune per indurre la lesione cronica del fegato nei topi di alimentazione di una dieta di colina-carenti ed etionina-completati (CDE). Dimostriamo che la sorveglianza sanitaria, aspersione epatica, isolamento e conservazione. Un corso di sei settimane di tempo può informare circa il disturbo al fegato, pathohistology, fibrosi, infiammatoria e risposte delle cellule progenitrici del fegato.
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