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DOI :
10.3791/56410-v
•
8:32 min
January 4th, 2018
Chapters
0:05
Title
1:21
Preparation of Micro-osmotic Pump Infusion Systems
2:41
Intracerebral Ventricular Surgery - Implantation of the Micro-osmotic Pump
4:15
Oral Glucose Tolerance Test (OGTT) and Insulin Tolerance Test (ITT)
6:04
Results: Glucose Metabolism and Insulin Signal Activation
7:27
Conclusion
该协议研究的作用趋化因子 (c-c 主题) 配体 5 (CCL5) 在下丘脑通过提供拮抗剂,满足CCL5, 进入鼠标的大脑使用微渗透泵脑输液系统。这种瞬态抑制 CCL5 活动阻断了下丘脑胰岛素信号, 导致葡萄糖不耐受和外周系统胰岛素敏感性。
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