Creando un modelo geométrico realista estructural de elementos finitos de cardiomiocitos para estudiar el papel de la arquitectura celular de cardiomiocitos biología de sistemas
April 18th, 2018
•Vijay Rajagopal1,2,3, Gregory Bass2,3, Shouryadipta Ghosh1,2,3, Hilary Hunt2,4, Cameron Walker5, Eric Hanssen6, Edmund Crampin2,3,4,7,8, Christian Soeller9
1Cell Structure and Mechanobiology Group, University of Melbourne, 2Systems Biology Laboratory, Melbourne School of Engineering, University of Melbourne, 3Department of Biomedical Engineering, University of Melbourne, 4School of Mathematics and Statistics, Faculty of Science, University of Melbourne, 5Department of Engineering Science, University of Auckland, 6Advanced Microscopy Facility, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 7ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, University of Melbourne, 8School of Medicine, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, 9Living Systems Institute, University of Exeter
Este protocolo describe un método novedoso para crear un modelo de elementos finitos espacial detallada de la arquitectura intracelular de cardiomiocitos de imágenes de microscopía confocal y microscopia electrónica. La potencia de este modelo espacial detallada se demuestra mediante estudios de caso en la señalización de calcio y bioenergética.
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