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JoVE Journal

Chemistry

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Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine

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09:14 min

February 16th, 2018

February 16th, 2018

11,899 Views

0:04

Title

0:48

Semi-preparative One-pot Biocatalytic Reaction, Reaction Monitoring, and Product Analysis

3:17

Semi-preparative One-pot Biocatalytic Reaction: Second and Third Steps

6:01

Results: Investigation of Pyridoxal Phosphate Dependent Decarboxylase (PLP DC) Activities towards Hydroxy Lysine Derivatives

7:56

Conclusion

Transcript

The overall goal of this procedure is to synthesize and purify Chiral Amino Alcohols, which are compounds with a wide range of applications from Chiral auxiliaries for organic synthesis to pharmaceutical therapy. This is an all yielding meter to g

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Chiral amino alcohols are versatile molecules for use as scaffolds in organic synthesis. Starting from L-lysine, we synthesize amino alcohols by an enzymatic cascade reaction combining diastereoselective C-H oxidation catalyzed by dioxygenase followed by cleavage of the carboxylic acid moiety of the corresponding hydroxyl amino acid by a decarboxylase.

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