Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysineAurélie Fossey-Jouenne 1, Carine Vergne-Vaxelaire 1, Anne Zaparucha 1
1Génomique Métabolique, Genoscope, Institut François Jacob, CEA, CNRS, Univ Evry, Univ Paris-Saclay
Chiral amino alcohols are versatile molecules for use as scaffolds in organic synthesis. Starting from L-lysine, we synthesize amino alcohols by an enzymatic cascade reaction combining diastereoselective C-H oxidation catalyzed by dioxygenase followed by cleavage of the carboxylic acid moiety of the corresponding hydroxyl amino acid by a decarboxylase.
