Vurdering av den cytotoksiske og immunmodulerende effekter av stoffer i menneskelig presisjonsstyrte kutte lunge skiver
May 9th, 2018
•Vanessa Neuhaus1*, Olga Danov1*, Sebastian Konzok1, Helena Obernolte1, Susann Dehmel1, Peter Braubach2, Danny Jonigk2, Hans-Gerd Fieguth3, Patrick Zardo4, Gregor Warnecke4, Christian Martin5, Armin Braun1,6, Katherina Sewald1
1Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), German Center for Lung Research (DZL), Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of REBIRTH Cluster of Excellence, 2Institute for Pathology, Hannover Medical School, German Center for Lung Research (DZL), Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), 3Division of Thoracic and Vascular Surgery, Klinikum Region Hannover (KRH), 4Department of Cardiothoracic, Transplantation and Vascular Surgery (HTTG), Hannover Medical School, German Center for Lung Research (DZL), Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), 5Institute of Pharmacology and Toxicology, RWTH Aachen University, 6Institute for Immunology, Hannover Medical School
I lys av 3Rs prinsipp, er åndedretts modeller som alternativer til dyrestudier utvikling. Spesielt for risikovurdering av respiratoriske stoffer er det mangel på passende analyser. Her beskriver vi bruk av menneskelige presisjonsstyrte kutte lunge skiver for vurdering av luftbåren stoffer.
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