Name: a simple non-invasive method for temporary knockdown of upper limb proprioception
Uploaded: 2018-03-03T14:00:00
Description: Watch this Scientific Journal Video about A Simple Non-invasive Method for Temporary Knockdown of Upper Limb Proprioception at JoVE.com

作者们想确认乔恩博士, PT, 进行分析, 以确定振动频率的振子在本协议中使用。

st. Scholastica 学院的机构审查委员会批准了这项议定书的编写和测试。
注: 本协议中使用的振动器的制造商规格表明, "高" 的频率为 1100 rpm (183.3 赫兹)。这一频率是通过一个采样的振动数据收集通过一个输入的差分放大器采样在2赫。信号的平均周期为 5.56 x 10-3 s, 相当于 180 Hz。在患有雷诺疾病的个体中, 振动可能会引起雷诺的现象, 在应用场所的临时血管收缩, 可能持续?...

<ol>
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本协议提供了一种在上肢中击倒人体本体的方法。在20健康参与者中, 本体击倒的效果很大, 视屏的心理测量方法反映 Aα传入轴突传输。当 Aα传入放电减少时, 在振动消除后, 可快速测量出该视屏。25此协议对到达目标具有视觉闭塞 (tBKT) 的错误的影响是适度的。这可能反映出, 该议定书只涉及一个单一的振动刺激在肘部, 一个联合在多关节的任务达成。关于其他可用的方法, 如缺血...

在神经控制运动的所有贡献者中, 本体可能是测量得最少的。本体使用专用设备的研究措施, 最近取得了可靠性、有效性和精确性;1,2,3相比之下, 本体的临床措施, 最常见的肢体位置感测试,4有低分辨率, 受到其他感官方式,4 , 并有不良或没有发表的心理测量属性。5需要新的精确、可靠的本体措施来阐明本体控制的外围和中枢机制、3用于临床诊断损伤, 并测量本体训练的结果。2,5,6,7为此, 需要一个简单的、非侵入性的方法来暂时损害或 "击倒" 本体。
本体击倒在健康的人允许研究人员推断本体功能的作用在一个感觉运动的任务, 这是有用的, 以通知发展和验证标准化措施。被击倒的模型有两个主要好处比研究人与损伤的本体。第一个是参与者的可用性;许多研究人员不容易接触到有本体损伤的个体。第二, 与体内本体损伤不同, 击倒模型可能允许控制参与者之间的损伤程度。
目前发布的方法的临时本体击倒的上肢是侵入, 不切实际, 或不舒服的参与者。麻醉注射虽然相对安全, 但需要技术专长, 可能被一些研究参与者认为是侵入性的。缺血性神经阻滞引起的不适和血液测试, 以筛查凝血障碍之前, 他们的应用是实践。8冷冻也会引起不适。冷冻治疗的平均使用时间为20.3 本体5.3 分钟9一旦冷冻被删除, 一个简短的窗口, 以测量本体之前, 温遗骸, 这可能导致不一致的效果关节位置感的冷冻治疗。10高频 (300 Hz) 振动成功地用于减少手指运动检测任务中的本体灵敏度;该机制被报告为小细胞诱导抑制其他振动敏感皮肤受体的输入。11最近, 通过对本体信息进行扭曲, 发现比目鱼肌振动 (80 Hz) 可以降低等距力的生产精度。12然而, 还没有发布一个简单的非侵入性的方法来暂时击倒上肢本体。
该方法的目的是利用高频振动暂时击倒上肢本体在健康的成年人。采用两种测量方法, 即振动检测阈值 (动觉) 和平板版的简单测试 (tBKT) 确定了击倒。视屏是反映 Aα传入轴突传输的敏感性思维的心理测量方法。13本体性能是使用我们实验室正在开发的 tBKT 进行量化的。简要的动觉测试 (BKT) 基于艾尔斯的工作, 14 是一项实验性仪器, 经测试, 但未列入国家卫生研究院工具箱核心电池.15,16 BKT 包括对每个上肢的三个达到的试验。tBKT 包括每上肢20项试验, 目前正在研制, 目的是提高对原试验的心理测量性能。tBKT 包括感觉输入 (对目标的上部肢体的考官教导), 中央处理 (记住目标的空间位置) 和马达输出 (试图找到目标在指南被去除之后), 认为是必要的在措施整体本体性能。17屏和 tBKT 测量, 分别表示体感层次结构中的低和高级别,18 , 因此应提供比单独使用的任何度量值更全面的本体量化。
两种神经机制与高频振动引起的本体灵敏度密切相关。首先, 小体是最常见的与振动检测相关的皮肤 mechanoreceptor。该协议中使用的连续振动可能会根据 Aα和β纤维组与小小体相关的短期适应的神经机制, 提高振动检测的受体调谐阈值。19生理上的结果是, 在视屏测试中, 使用相同强度和频率的振动, 如 128 Hz, 可在更短的时间内感觉到。第二, 据认为, 肌肉纺锤, 通过 Aα传入纤维, 编码肌肉长度不准确后, 高频振动导致失真的本体信息, 证明通过降低准确性在部队再生产,12移动错觉,20,21和减少动觉。22

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			<td height="40" style="height:40px;width:329px;">Pure Enrichment-Massage Mini with Built in USB Rechargeable Battery</td>
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			<td height="40" style="height:40px;">Chattanooga 2.5 inch velcro strap&#160;</td>
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			<td>used to secure vibrator to arm</td>
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			<td colspan="4" height="40" style="height:40px;">Instructions to build Visual Screen were published here: https://www.jove.com/video/53178/design-fabrication-administration-hand-active-sensation-test&#160;</td>
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a simple non-invasive method for temporary knockdown of upper limb proprioception

本体可能是对运动的神经控制的所有贡献者的最不充分的测量。本体的临床诊断需要新的精确、可靠的测量方法, 并测量本体训练的结果。这种简单的, 无创的方法的目的是暂时击倒上肢本体在健康的成年人, 在一定程度上将有助于发展和测试上肢本体措施。击倒模型有两个主要的优势超过研究的人与受损本体: 参与者的可用性和能力, 以控制损害程度, 在参加者。目前发布的方法的临时本体击倒的上肢, 如缺血性神经阻滞和冷冻, 是侵入, 不切实际, 或不舒服的参与者。在这里, 尺沟的振动被用来减少上肢本体。高频振动可抑制小细胞诱导输入, 降低本体视力。采用两种定量方法确定了该协议的振动效果。该方法管理简单, 适合参加者, 实用性强。

使用这里介绍的协议, 我们测试了20健康成人, 8 是男性 (平均年龄 (SD) = 32.5 (12.5) 年; 19 右, 和1左手)。参加者没有已知的病理涉及上肢。使用爱丁堡惯用手的清单对惯用手进行了评估。24研究参与者未报告任何不良事件。
每位参加者的上肢都在两个单独的疗程, 一周的时间内用 tBKT 和双腿进行测试。如《议定书?...

Watch this Scientific Journal Video about A Simple Non-invasive Method for Temporary Knockdown of Upper Limb Proprioception at JoVE.com

A Simple Non-invasive Method for Temporary Knockdown of Upper Limb Proprioception

本议定书的目的是演示一种实用的方法来暂时干预健康人上肢的本体。

一种简单无创的上肢本体临时击倒方法

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Simple and Computer-assisted Olfactory Testing for Mice

简单和计算机辅助测试嗅觉的小鼠

Olfaction is highly conserved among species and is required for reproduction and survival.
In humans, olfaction is also one of the senses that is affected ...

Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function

非侵入电脑刺激蒙太奇的人体运动功能的调节

Non-invasive electrical brain stimulation (NEBS) is used to modulate brain function and behavior, both for research and clinical purposes. In particular, ...

Event-related Potentials During Target-response Tasks to Study Cognitive Processes of Upper Limb Use in Children with Unilateral Cerebral Palsy

事件相关电位在目标响应的任务，研究的上肢使用在儿童认知过程单侧脑性麻痹

Unilateral Cerebral Palsy (CP) is a neurodevelopmental disorder that is a very common cause of disability in childhood. It is characterized by unilateral ...

Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans

在人类联合微创皮层下和非侵入性的表面神经生理学录音认知的评估和情感作用

In spite of the success in applying non-invasive electroencephalography (EEG), magneto-encephalography (MEG) and functional magnetic resonance imaging ...

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

跑步机疲劳试验：疲劳类似的行为，为鼠标操作简单，高通量检测

Fatigue is a prominent symptom in many diseases and disorders and reduces quality of life for many people. The lack of clear pathogenesis and failure of ...

Sit-to-stand-and-walk from 120% Knee Height: A Novel Approach to Assess Dynamic Postural Control Independent of Lead-limb

坐姿到站姿和步行距离120％膝盖高度：新方法来评估铅肢体的动态姿势控制独立

Individuals with sensorimotor pathology e.g., stroke have difficulty executing the common task of rising from sitting and initiating gait (sit-to-walk: ...

A Method to Test the Effect of Environmental Cues on Mating Behavior in Drosophila melanogaster

A Method to Test the Effect of Environmental Cues on Mating Behavior in Drosophila melanogaster

测试环境线索对交配行为的影响的方法<em&gt;黑腹果蝇</em

An individual's sexual drive is influenced by genotype, experience and environmental conditions. How these factors interact to modulate sexual behaviors ...