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Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays

DOI :

10.3791/57548-v

10:24 min

May 15th, 2018

May 15th, 2018

13,913 Views

1Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, 2Rehab Technologies, Istituto Italiano di Tecnologia

We illustrate how to perform recording and electrical modulation of 4-aminopyridine-induced epileptiform activity in rodent brain slices using microelectrode arrays. A custom recording chamber maintains tissue viability throughout prolonged experimental sessions. Live electrode mapping and selection of stimulating pairs are performed by a custom graphical user interface.

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Recording

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